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Can daily breathing measurements tell doctors when It's safe to remove a ventilator?

NCT ID NCT07839949

Knowledge-focused Sponsor: Fundació d'investigació Sanitària de les Illes Balears Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Researchers are studying whether daily measurements of a patient's breathing effort can predict successful removal from a mechanical ventilator. The study includes 120 adults who have been on a ventilator for at least 36 hours and are transitioning to a mode where they breathe with some support. Starting at that transition, the team tracks four breathing measures each day using the ventilator and ultrasound, and records safety parameters. They will analyze whether these patterns predict who can breathe on their own for 72 hours, while also tracking complications like pneumonia and muscle weakness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the approach works, doctors could use daily breathing measurements to decide more precisely when to remove a ventilator, potentially shortening time on the machine and lowering complications.
What could go wrong
This is an observational study, so it can show patterns but cannot prove that monitoring causes better outcomes. The results may not apply to patients with neuromuscular disease or other excluded groups, and the statistical models may not predict weaning accurately in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to Intensive Care Unit who require invasive mechanical ventilation due to any cause with 36 hours or more with a controlled mode of mechanical ventilation and deep sedation

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years old or more. * Patients undergoing invasive mechanical ventilation for any cause under a controlled ventilation mode for more than 36 hours. * Attending physician's decision to initiate pressure support ventilation according to standard clinical practice. Exclusion Criteria: * Pregnancy. * Degenerative neuromuscular disease (e.g., amyotrophic lateral sclerosis, congenital myopathies). * Air leak/fistula that prevents breathing-pause maneuvers. * Diaphragmatic paralysis. * Limitation of life-sustaining treatment in case of weaning failure. * Conditions preventing follow-up up to 72 hours after liberation from mechanical ventilation. * Use of neuromuscular blocking agents within the last 24 hours.

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Conditions

The condition(s) this trial relates to.

Critical Illness respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Monitoring, physiologic Respiratory insufficiency requiring mechanical ventilation Respiratory mechanics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Intensive Care Medicine, Hospital Universitario Son Espases

    RECRUITING

    Palma de Mallorca, Balearic Islands, 07120, Spain

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