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Could a gentler breath test replace the harsh blow for COPD diagnosis?

NCT ID NCT07798596

Diagnosis Sponsor: University Hospital Southampton NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tests whether newer breathing technologies, such as capnography and oscillometry, can diagnose COPD as accurately as the standard spirometry test. Spirometry requires forceful blowing, which can be uncomfortable. Researchers will compare these tests in 300 adults with suspected airway disease, in both hospital and community settings, to see how accurate, practical, and cost-effective they are.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Capnography, oscillometry, fractional exhaled nitric oxide (FENO), and gas transfer tests, used with or without machine learning algorithms
What this could lead to
If these newer tests work well, they could offer a more comfortable and practical way to diagnose COPD, especially for people who find standard spirometry difficult.
What could go wrong
This is an early study, and the tests may not prove accurate enough to replace standard methods. Some tests may be less feasible in community settings or have higher failure rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with a clinical suspicion of COPD/airway disease referred for spirometry testing at local community diagnostic centres or for lung function testing at secondary care hospitals. Additionally, adults attending for a low-dose CT scan as part of the lung cancer screening programme or adults attending local community groups or events

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥ 18 years of age * New referral to community or secondary healthcare services * Clinical suspicion of airway disease/COPD * Able to provide fully informed written consent * Able to fully understand and cooperate with the study protocol * Clinically stable with no contraindications to lung function testing (outlined below) Exclusion Criteria: * Confirmed diagnosis of COPD * Not willing and/or able to provide fully informed written consent to participate * Has a relative contraindication to lung function testing \[18\]: * Recent thoracic, abdominal or eye (e.g. cataract) surgery \< 6 weeks * Unstable cardiovascular status, including recent myocardial infarction or pulmonary embolus \< 6 weeks * Pneumothorax \< 6 weeks * Haemoptysis of unknown origin \< 6 weeks * Thoracic, abdominal or cerebral aneurysm * Chest infection \< 6 weeks * An acute illness or symptom that might interfere with test performance (e.g. nausea, vomiting). * The presence of any other clinical condition that would prevent the individual from safely performing lung function tests

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Airway disease COPD, chronic obstructive pulmonary disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hampshire Hospitals NHS Foundation Trust

    Andover, Hampshire, SP10 3LB, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    Southampton, Hampshire, SO16 6YD, United Kingdom

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