New pill aims to outsmart mutating breast cancer

NCT ID NCT04964934

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is for people with advanced, hormone-driven breast cancer that has developed a specific gene mutation (ESR1) while on standard treatment. It tests if switching from a common type of hormone pill (an aromatase inhibitor) to a new experimental pill (AZD9833), while keeping the same other cancer drug (a CDK4/6 inhibitor), can keep the cancer from growing longer. About 315 participants will be randomly assigned to either switch to the new drug or continue their current treatment to see which approach works better.

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Contacts and locations

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Locations

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Phoenix, Arizona, 85054, United States
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Hot Springs, Arkansas, 71913, United States
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Little Rock, Arkansas, 72205, United States
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Long Beach, California, 90806, United States
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San Diego, California, 92123, United States
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Santa Rosa, California, 92805, United States
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Grand Junction, Colorado, 81501, United States
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Lone Tree, Colorado, 80124, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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Jacksonville, Florida, 32256, United States
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St. Petersburg, Florida, 33705, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Atlanta, Georgia, 30342, United States
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Park Ridge, Illinois, 60068, United States
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Fort Wayne, Indiana, 46804, United States
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Indianapolis, Indiana, 46250, United States
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Baltimore, Maryland, 21202, United States
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Boston, Massachusetts, 02215, United States
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Fairhaven, Massachusetts, 02719, United States
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Foxborough, Massachusetts, 02035, United States
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Milford, Massachusetts, 01757, United States
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South Weymouth, Massachusetts, 02190, United States
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Detroit, Michigan, 48202, United States
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Grand Rapids, Michigan, 49503, United States
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Rochester, Minnesota, 55905, United States
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Oxford, Mississippi, 38655, United States
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Kansas City, Missouri, 64111, United States
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St Louis, Missouri, 63110, United States
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Billings, Montana, 59101, United States
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Omaha, Nebraska, 68130, United States
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Camden, New Jersey, 08103, United States
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Ridgewood, New Jersey, 07450, United States
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Brooklyn, New York, 11215, United States
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East Syracuse, New York, 13057, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10065, United States
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New York, New York, 11355, United States
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Shirley, New York, 11967, United States
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Goldsboro, North Carolina, 27534, United States
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Canton, Ohio, 44710, United States
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Cincinnati, Ohio, 45220, United States
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Columbus, Ohio, 43219, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15213, United States
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York, Pennsylvania, 17403, United States
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Greenville, South Carolina, 29607, United States
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West Columbia, South Carolina, 29169, United States
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Knoxville, Tennessee, 37916, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Bedford, Texas, 76022, United States
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Dallas, Texas, 75246, United States
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Houston, Texas, 77024, United States
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Houston, Texas, 77030, United States
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Irving, Texas, 75063, United States
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Longview, Texas, 75601, United States
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San Antonio, Texas, 78240, United States
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Salt Lake City, Utah, 84106, United States
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Midlothian, Virginia, 23114, United States
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Norfolk, Virginia, 23502, United States
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Tacoma, Washington, 98405, United States
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Waukesha, Wisconsin, 53226, United States
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Birtinya, 4575, Australia
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Darlinghurst, 2010, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Salzburg, 5020, Austria
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Vienna, 1130, Austria
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Haskovo, 6300, Bulgaria
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Panagyurishte, 4500, Bulgaria
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Pleven, 5804, Bulgaria
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Plovdiv, 4004, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1527, Bulgaria
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Calgary, Alberta, T2N 5G2, Canada
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Vancouver, British Columbia, V5Z 4E6, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Lévis, Quebec, G6V 3Z1, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2X 0C1, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Québec, Quebec, G1S 4L8, Canada
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Avignon, 84918, France
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Brest, 29200, France
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Clermont-Ferrand, 63050, France
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Dijon, 21079, France
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Limoges, 83000, France
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Lorient, 56322, France
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Lyon, 69373, France
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Marseille, 13273, France
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Metz-Tessy, 74370, France
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Nîmes, 30029, France
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Paris, 75248, France
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Rouen, 76021, France
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Saint-Cloud, 92210, France
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Saint-Herblain, 44805, France
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Toulouse, 31100, France
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Tours, 37000, France
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Vandœuvre-lès-Nancy, 54519, France
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Vantoux, 57070, France
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Villejuif, 94805, France
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Ansbach, 91522, Germany
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Aschaffenburg, 63739, Germany
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Augsburg, 86156, Germany
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Bonn, 53111, Germany
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Chemnitz, 09116, Germany
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Dresden, 01307, Germany
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Erlangen, 91054, Germany
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Essen, 45130, Germany
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Freiburg im Breisgau, 79110, Germany
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Immenstadt im Allgäu, 87509, Germany
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Koblenz, 56068, Germany
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Leipzig, 4103, Germany
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Mannheim, 68167, Germany
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München, 80634, Germany
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Paderborn, 33098, Germany
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Ratingen, 40878, Germany
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Ravensburg, 88212, Germany
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Regensburg, 93053, Germany
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Stade, 21680, Germany
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Tübingen, 72076, Germany
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Ulm, 89075, Germany
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Budapest, 1062, Hungary
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Budapest, 1122, Hungary
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Miskolc, 3526, Hungary
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Szekszárd, 7100, Hungary
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Szolnok, 5000, Hungary
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Zalaegerszeg, 8900, Hungary
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Beersheba, 8410101, Israel
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Petah Tikva, 494142, Israel
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Ramat Gan, 5262000, Israel
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Misterbianco, 95045, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Chiba, 260-8717, Japan
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Hirakata-shi, 573-1191, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 467-8602, Japan
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Niigata, 951-8566, Japan
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Osaka, 540-0006, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Takasaki-shi, 370-0829, Japan
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Takatsuki-shi, 569-8686, Japan
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Tsukuba, 305-8577, Japan
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Yokohama, 241-8515, Japan
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Drammen, 3004, Norway
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Oslo, 0450, Norway
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Bydgoszcz, 85-796, Poland
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Gdynia, 81-519, Poland
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Koszalin, 75-581, Poland
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Lodz, 90-302, Poland
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Poznan, 60-693, Poland
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Rzeszów, 35-001, Poland
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Tomaszów Mazowiecki, 97-200, Poland
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Warsaw, 02-781, Poland
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Guimarães, 4835-044, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1449-005, Portugal
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Lisbon, 1500-650, Portugal
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Lisbon, 1649-035, Portugal
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Loures, 2674-514, Portugal
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Porto, 4099-001, Portugal
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Porto, 4200-072, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Moscow, 111123, Russia
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Moscow, 129090, Russia
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Moscow, 143423, Russia
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Nizhny Novgorod, 603126, Russia
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Podolsk, 142100, Russia
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Saint Petersburg, 194017, Russia
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Saint Petersburg, 197758, Russia
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Banská Bystrica, 974 01, Slovakia
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Bratislava, 833 01, Slovakia
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Košice, 041 91, Slovakia
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Michalovce, 07101, Slovakia
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Partizánske, 958 01, Slovakia
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Cheonan-si, 31151, South Korea
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Daegu, 42415, South Korea
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Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Seongnam-si, 463-712, South Korea
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Seoul, 02841, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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A Coruña, 15009, Spain
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Badalona, 08003, Spain
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Barcelona, 8035, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Murcia, 30008, Spain
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Sant Joan Despí, 08970, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Bern, CH-3010, Switzerland
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Chur, CH-7000, Switzerland
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Winterthur, 8401, Switzerland
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Kaohsiung City, 833, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Tainan, 710, Taiwan
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Taipei, 100, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11259, Taiwan
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Taipei, 11490, Taiwan
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Taipei, 23561, Taiwan
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Taipei, Taiwan
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Taoyuan District, 333, Taiwan
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Adana, 01120, Turkey (Türkiye)
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06340, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35360, Turkey (Türkiye)
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Kadıkoy/Istanbul, 34722, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Blackpool, FY3 8NR, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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London, SW3 6JJ, United Kingdom
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London, WC1N 3BG, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Newport, NP10 8FZ, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Reading, RG2 9LH, United Kingdom
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Sheffield, S10 2SJ, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Taunton, TA1 5DA, United Kingdom

Conditions

Explore the condition pages connected to this study.

ER-POSITIVE HER2-NEGATIVE BREAST CANCER