Targeted combo shows promise for Tough-to-Treat breast cancer

NCT ID NCT03056755

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the drug alpelisib to standard hormone therapy could help control advanced breast cancer that had a specific genetic change (PIK3CA mutation) and had worsened despite prior treatments. It involved 383 men and women whose cancer was hormone-receptor positive and HER2-negative. The goal was to see if this combination could stop the cancer from growing for a meaningful period of time.

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Contacts and locations

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Locations

Advent Health Cancer Institute

Orlando, Florida, 32804, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Beverly Hills Cancer Center

Beverly Hills, California, 90211, United States
Cancer Care Centers of South Texas HOAST

San Antonio, Texas, 78229, United States
Greater Baltimore Med Center Cancer Center

Baltimore, Maryland, 21204, United States
Josephine Ford Cancer Center

Detroit, Michigan, 48202, United States
Kaiser Permanent Southern Californi

San Diego, California, 92120, United States
Kaiser Permanente Medical Group

Anaheim, California, 92807, United States
Lahey Clinic

Burlington, Massachusetts, 01805, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States
Memorial Sloane Ketterin Cancer Ctr

New York, New York, 10065, United States
Mercy Medical Center

Baltimore, Maryland, 21202, United States
New Mexico Cancer Care Alliance

Albuquerque, New Mexico, 87106, United States
Northwest Medical Specialists

Tacoma, Washington, 98405, United States
Novartis Investigative Site

CABA, Buenos Aires, C1118AAT, Argentina
Novartis Investigative Site

CABA, Buenos Aires, C1125ABD, Argentina
Novartis Investigative Site

CABA, Buenos Aires, C1426ANZ, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, S2000DSV, Argentina
Novartis Investigative Site

Rosario, Sante Fe, S200KZE, Argentina
Novartis Investigative Site

La Rioja, 5300, Argentina
Novartis Investigative Site

Leuven, 3000, Belgium
Novartis Investigative Site

Liège, 4000, Belgium
Novartis Investigative Site

Vancouver, British Columbia, V5Z 4E6, Canada
Novartis Investigative Site

Halifax, Nova Scotia, B3H 2Y9, Canada
Novartis Investigative Site

Kitchener, Ontario, N2G 1G3, Canada
Novartis Investigative Site

Toronto, Ontario, M5B 1N9, Canada
Novartis Investigative Site

Temuco, Región de la Araucanía, 4810469, Chile
Novartis Investigative Site

Santiago, 7500921, Chile
Novartis Investigative Site

Santiago, 8420383, Chile
Novartis Investigative Site

Odense C, 5000, Denmark
Novartis Investigative Site

Vejle, DK-7100, Denmark
Novartis Investigative Site

Nice, Alpes Maritimes, 06189, France
Novartis Investigative Site

Saint-Cloud, Hauts De Seine, 92210, France
Novartis Investigative Site

Bordeaux, 33076, France
Novartis Investigative Site

Caen, 14021, France
Novartis Investigative Site

Lille, 59020, France
Novartis Investigative Site

Lyon, 69373, France
Novartis Investigative Site

Montpellier, 34298, France
Novartis Investigative Site

Saint-Herblain, 44805, France
Novartis Investigative Site

Strasbourg, 67000, France
Novartis Investigative Site

Toulouse, 31059, France
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Augsburg, 86150, Germany
Novartis Investigative Site

Berlin, 14169, Germany
Novartis Investigative Site

Erlangen, 91054, Germany
Novartis Investigative Site

Essen, 45136, Germany
Novartis Investigative Site

Heidelberg, 69120, Germany
Novartis Investigative Site

Ulm, 89081, Germany
Novartis Investigative Site

Delhi, 110085, India
Novartis Investigative Site

Petah Tikva, 4941492, Israel
Novartis Investigative Site

Ramat Gan, 5265601, Israel
Novartis Investigative Site

Rehovot, 7661041, Israel
Novartis Investigative Site

Tel Aviv, 6423906, Israel
Novartis Investigative Site

Ancona, AN, 60126, Italy
Novartis Investigative Site

Bergamo, BG, 24127, Italy
Novartis Investigative Site

Bologna, BO, 40138, Italy
Novartis Investigative Site

Genova, GE, 16132, Italy
Novartis Investigative Site

Milan, MI, 20133, Italy
Novartis Investigative Site

Milan, MI, 20141, Italy
Novartis Investigative Site

Roma, RM, 00168, Italy
Novartis Investigative Site

Napoli, 80131, Italy
Novartis Investigative Site

Osaka, Osaka, 540-0006, Japan
Novartis Investigative Site

Jalisco, 45640, Mexico
Novartis Investigative Site

Maastricht, Limburg, 6229 HX, Netherlands
Novartis Investigative Site

Singapore, 168583, Singapore
Novartis Investigative Site

Singapore, 217562, Singapore
Novartis Investigative Site

Seoul, Korea, 03080, South Korea
Novartis Investigative Site

Seoul, 06351, South Korea
Novartis Investigative Site

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site

Salamanca, Castille and León, 37007, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08035, Spain
Novartis Investigative Site

Barcelona, 08036, Spain
Novartis Investigative Site

Castellon, 12002, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Seville, 41013, Spain
Novartis Investigative Site

Tainan, 70403, Taiwan
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Taipei, 103616, Taiwan
Novartis Investigative Site

Edinburgh, Scotland, EH4 2XU, United Kingdom
Novartis Investigative Site

Sutton, Surrey, SM2 5PT, United Kingdom
Novartis Investigative Site

Leicester, LE2 7LG, United Kingdom
Novartis Investigative Site

London, SW3 6JJ, United Kingdom
Novartis Investigative Site

Nottingham, NG5 1PB, United Kingdom
St Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Texas Oncology

Dallas, Texas, 75246, United States
UCSF

San Francisco, California, 94115, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
Uni Hosp of Cleveland Cancer Center

Cleveland, Ohio, 44106, United States
University of Calif Irvine Med Cntr

Irvine, California, 92660, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66205, United States
University of Louisville James Graham Brown Cancer Center

Louisville, Kentucky, 40202, United States
Virginia Oncology Associates

Norfolk, Virginia, 23502, United States
Yale University Yale Cancer Center

New Haven, Connecticut, 06511, United States

Conditions

Explore the condition pages connected to this study.

BREAST CANCER