New drug combo tested to shrink breast tumors before surgery
NCT ID NCT06465368
Summary
This study tested whether adding a new drug called PF-07220060 to standard hormone therapy (letrozole) works better than letrozole alone to shrink breast tumors before surgery. It involved 121 postmenopausal women with a specific type of breast cancer (HR-positive, HER2-negative) who hadn't received any prior cancer treatment. Participants took the medications for 14 days and had tumor biopsies to measure how the treatment affected cancer cell growth.
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Contacts and locations
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Locations
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AIDPORT Sp. z o.o.
Skórzewo, Greater Poland Voivodeship, 60-185, Poland
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AMG -Crystal Lake
Crystal Lake, Illinois, 60014, United States
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Advocate Good Shepherd Hospital
Barrington, Illinois, 60010, United States
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Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068, United States
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Advocate Medical Group
Park Ridge, Illinois, 60068, United States
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Akademiska sjukhuset
Uppsala, Uppsala LÄN [se-03], 751 85, Sweden
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Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, 28100, Italy
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Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno
Livorno, Tuscany, 57124, Italy
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Baylor College of Medicine Medical Center
Houston, Texas, 77030, United States
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Baylor St. Luke's Medical Center
Houston, Texas, 77030, United States
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Ben Taub General Hospital
Houston, Texas, 77030, United States
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CHU de Saint-Etienne
Saint Priest En Jarez, Pays de la Loire Region, 42271, France
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CaritasKlinikum Saarbrücken St. Theresia
Saarbrücken, Saarland, 66113, Germany
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Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
Rennes, Ille-et-vilaine, 35042, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône, 69310, France
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Centre de Cancérologie du Grand Montpellier
Montpellier, Languedoc-roussillon, 34070, France
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
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Gustave Roussy
Villejuif, Val-de-marne, 94800, France
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HCL, Centre Hospitalier Lyon Sud
Saint-Genis-Laval, Rhône, 69230, France
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Harris Health System - Smith Clinic
Houston, Texas, 77054, United States
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Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, Región de, 30120, Spain
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Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Comunidad de, 28009, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
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Hospital Jerez de la Frontera
Jerez de la Frontera, Cádiz, 11407, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Hospital Universitario San Cecilio
Granada, 18016, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Málaga, 29010, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [cataluña], 08041, Spain
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, 47014, Italy
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Institut Jules Bordet
Anderlecht, Bruxelles-capitale, Région de, 1070, Belgium
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Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-atlantique, 44805, France
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Kantonsspital Baden
Baden, 5404, Switzerland
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Mackay Memorial Hospital
Taipei, 10449, Taiwan
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Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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Nemocnica AGEL Komarno
Komárno, Nitra Region, 945 05, Slovakia
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O'Quinn Medical Tower - McNair Campus
Houston, Texas, 77054, United States
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Ospedale Antonio Perrino
Brindisi, 72100, Italy
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Royal Melbourne Hospital
Parkville, Victoria, 3052, Australia
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START San Antonio
San Antonio, Texas, 78229, United States
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Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
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Sjukhuset I Gävle
Gävle, Gävleborgs LÄN [se-21], 80187, Sweden
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Tumor Zentrum Aarau
Aarau, Canton of Aargau, 5000, Switzerland
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UZ Leuven
Leuven, Vlaams-brabant, 3000, Belgium
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University Hospital Basel
Basel, Canton of Basel-City, 4031, Switzerland
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Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, Podkarpackie Voivodeship, 37-700, Poland
Conditions
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