Major trial aims to stop breast Cancer's return

NCT ID NCT03701334

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing whether adding a drug called ribociclib to standard hormone therapy can better prevent cancer from returning in people with a common type of early-stage breast cancer. It enrolled over 5,000 men and women who had surgery and are at higher risk of their cancer coming back. The main goal is to see if this combination helps people live longer without their cancer returning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Baylor Charles A Sammons Cancer Cnt

Dallas, Texas, 75246, United States
Cancer Care Associates Medical Grp

Redondo Beach, California, 90277, United States
Cancer Care Center

New Albany, Indiana, 47150, United States
Cancer Center of Kansas

Wichita, Kansas, 67214-3728, United States
Cancer Treatment Centers of America

Goodyear, Arizona, 85338, United States
Cancer Treatment Centers of America

Zion, Illinois, 60099, United States
Cancer Treatment Centers of America Eastern Regional Medical Center

Philadelphia, Pennsylvania, 19124, United States
Central Coast Medical Oncology Corporation

Santa Maria, California, 93454, United States
Comprehensive Blood and Cancer

Bakersfield, California, 93309, United States
Comprehensive Cancer Cntr Of Nevada

Henderson, Nevada, 89052, United States
Cone Health Cancer Center

Greensboro, North Carolina, 27403, United States
Ctr For Cancer And Blood Disorders

Fort Worth, Texas, 76104, United States
David C Pratt Cancer Center

St Louis, Missouri, 63141, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Encino Research Center

Encino, California, 91436, United States
Fairview Health Services

Maple Grove, Minnesota, 55369, United States
Florida Cancer Specialists

Fort Myers, Florida, 33901, United States
Florida Cancer Specialists

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists Pan

Tallahassee, Florida, 32308, United States
Florida Cancer Specialists-North

St. Petersburg, Florida, 33705, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
HCA Midwest Division

Kansas City, Missouri, 64132, United States
Holy Cross Hospital-Ft. Lauderdale

Fort Lauderdale, Florida, 33308, United States
Hospital of Central Connecticut

New Britain, Connecticut, 06052, United States
Kaiser Permanente NW Region

Clackamas, Oregon, 97015, United States
Lundquist Inst BioMed at Harbor

Torrance, California, 90509-2910, United States
MD Anderson Cancer Center University of Texas

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Cancer Institute

Hollywood, Florida, 33021, United States
Mercy Medical Center

Baltimore, Maryland, 21202, United States
Metro Minnesota CCOP

Saint Louis Park, Minnesota, 55416, United States
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
Norwalk Hospital

Norwalk, Connecticut, 06856, United States
Novartis Investigative Site

Vitoria-Gasteiz, Araba, 01009, Spain
Novartis Investigative Site

Badalona, Barcelona, 08916, Spain
Novartis Investigative Site

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site

Manresa, Barcelona, 08242, Spain
Novartis Investigative Site

Sabadell, Barcelona, 08208, Spain
Novartis Investigative Site

Bilbao, Bizkaia, 48013, Spain
Novartis Investigative Site

Badajoz, Extremadura, 06080, Spain
Novartis Investigative Site

Cáceres, Extremadura, 10003, Spain
Novartis Investigative Site

Lugo, Galicia, 27003, Spain
Novartis Investigative Site

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Novartis Investigative Site

Fuenlabrada, Madrid, 28942, Spain
Novartis Investigative Site

Majadahonda, Madrid, 28222, Spain
Novartis Investigative Site

El Palmar, Murcia, 30120, Spain
Novartis Investigative Site

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site

Vigo, Pontevedra, 36212, Spain
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San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain
Novartis Investigative Site

Alicante, Valencia, 03550, Spain
Novartis Investigative Site

Valencia, Valencia, 46009, Spain
Novartis Investigative Site

A Coruña, 15006, Spain
Novartis Investigative Site

A Coruña, 15009, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Barcelona, 08036, Spain
Novartis Investigative Site

Burgos, 09006, Spain
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Castellon, 12002, Spain
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Córdoba, 14004, Spain
Novartis Investigative Site

Girona, 17007, Spain
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Granada, 18016, Spain
Novartis Investigative Site

Las Palmas GC, 35010, Spain
Novartis Investigative Site

Madrid, 28009, Spain
Novartis Investigative Site

Madrid, 28033, Spain
Novartis Investigative Site

Madrid, 28034, Spain
Novartis Investigative Site

Madrid, 28040, Spain
Novartis Investigative Site

Málaga, 29010, Spain
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Murcia, 30008, Spain
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Salamanca, 37007, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
Novartis Investigative Site

Valencia, 46010, Spain
Novartis Investigative Site

Valencia, 46014, Spain
Novartis Investigative Site

Zaragoza, 50009, Spain
Novartis Investigative Site

Changhua, 50006, Taiwan
Novartis Investigative Site

Taichung, 40447, Taiwan
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Taichung, 407219, Taiwan
Novartis Investigative Site

Tainan, 704302, Taiwan
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Taipei, 103616, Taiwan
Novartis Investigative Site

Taipei, 10449, Taiwan
Novartis Investigative Site

Taipei, 11217, Taiwan
Novartis Investigative Site

Taoyuan District, 33305, Taiwan
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Truro, Cornwall, TR1 3LJ, United Kingdom
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Sutton, Surrey, SM2 5PT, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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London, NW1 2BU, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW3 6JJ, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Oxford, OX3 7LE, United Kingdom
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Preston, PR2 9HT, United Kingdom
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Stoke-on-Trent, ST4 6QG, United Kingdom
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San Salvador de Jujuy, Jujuy Province, 4600, Argentina
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Rosario, Santa Fe Province, S2000, Argentina
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Rosario, Sante Fe, S200KZE, Argentina
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San Miguel Tucuman, Tucumán Province, T4000IAK, Argentina
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Rio Negro, Viedma, 8500, Argentina
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CABA, C1419AHN, Argentina
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Córdoba, X5004FHP, Argentina
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La Rioja, 5300, Argentina
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Campbelltown, New South Wales, 2560, Australia
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Coffs Harbour, New South Wales, 2450, Australia
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Darlinghurst, New South Wales, 2010, Australia
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Kingswood, New South Wales, 2747, Australia
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Kogarah, New South Wales, 2217, Australia
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North Ryde, New South Wales, 2109, Australia
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St Leonards, New South Wales, 2065, Australia
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Wahroonga, New South Wales, 2076, Australia
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Westmead, New South Wales, 2145, Australia
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Auchenflower, Queensland, 4066, Australia
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Birtinya, Queensland, 4575, Australia
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Wooloongabba, Queensland, 4102, Australia
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Bedford Park, South Australia, 5041, Australia
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Bendigo, Victoria, 3550, Australia
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East Melbourne, Victoria, 3002, Australia
Novartis Investigative Site

Epping, Victoria, 3076, Australia
Novartis Investigative Site

Fitzroy, Victoria, 3065, Australia
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Franston, Victoria, 3199, Australia
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Heidelberg, Victoria, 3084, Australia
Novartis Investigative Site

Melbourne, Victoria, 3000, Australia
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Shepparton, Victoria, 3630, Australia
Novartis Investigative Site

Murdoch, Western Australia, 6150, Australia
Novartis Investigative Site

Nedlands, Western Australia, 6009, Australia
Novartis Investigative Site

Liverpool, 2170, Australia
Novartis Investigative Site

Innsbruck, Tyrol, 6020, Austria
Novartis Investigative Site

Graz, 8036, Austria
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Linz, 4020, Austria
Novartis Investigative Site

Salzburg, 5020, Austria
Novartis Investigative Site

Vienna, 1090, Austria
Novartis Investigative Site

Hasselt, Limburg, 3500, Belgium
Novartis Investigative Site

Leuven, Vlaams Brabant, 3000, Belgium
Novartis Investigative Site

Brussels, 1000, Belgium
Novartis Investigative Site

Brussels, 1200, Belgium
Novartis Investigative Site

Charleroi, 6000, Belgium
Novartis Investigative Site

Edegem, 2650, Belgium
Novartis Investigative Site

Jette, 1090, Belgium
Novartis Investigative Site

Libramont, 6800, Belgium
Novartis Investigative Site

Liège, 4000, Belgium
Novartis Investigative Site

Namur, 5000, Belgium
Novartis Investigative Site

Wilrijk, 2610, Belgium
Novartis Investigative Site

Yvoir, 5530, Belgium
Novartis Investigative Site

Londrina, Paraná, 86015-520, Brazil
Novartis Investigative Site

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90560-030, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Novartis Investigative Site

Barretos, São Paulo, 14784 400, Brazil
Novartis Investigative Site

Santo André, São Paulo, 09060-650, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 01317 000, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 04014-002, Brazil
Novartis Investigative Site

Caxias do Sul, 95070-560, Brazil
Novartis Investigative Site

Passo Fundo, 99010-080, Brazil
Novartis Investigative Site

Piracicaba, 13419-155, Brazil
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Recife, 50040-000, Brazil
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Rio de Janeiro, 20560-120, Brazil
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Salvador, 41810 570, Brazil
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São Paulo, 01255-000, Brazil
Novartis Investigative Site

Calgary, Alberta, T2N4N2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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North Vancouver, British Columbia, V7L 2L7, Canada
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Surrey, British Columbia, V3V 1Z2, Canada
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Vancouver, British Columbia, V5Z 4E6, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Kitchener, Ontario, N2G 1G3, Canada
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London, Ontario, N6A 5W9, Canada
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Newmarket, Ontario, J7Y 2P9, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Sault Ste. Marie, Ontario, P6B 0A8, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Windsor, Ontario, N8W 2X3, Canada
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Fleurimont, Quebec, J1H 5N4, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H2W 1T8, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Guangzhou, Guangdong, 510000, China
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Shijiazhuang, Hebei, 050011, China
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Harbin, Heilongjiang, 150081, China
Novartis Investigative Site

Zhengzhou, Henan, 450008, China
Novartis Investigative Site

Wuhan, Hubei, 430022, China
Novartis Investigative Site

Nanjing, Jiangsu, 210029, China
Novartis Investigative Site

Suzhou, Jiangsu, 215004, China
Novartis Investigative Site

Changchun, Jilin, 130021, China
Novartis Investigative Site

Chengdu, Sichuan, 610041, China
Novartis Investigative Site

Hangzhou, Zhejiang, 310016, China
Novartis Investigative Site

Beijing, 100021, China
Novartis Investigative Site

Chongqing, 400016, China
Novartis Investigative Site

Shanghai, 200032, China
Novartis Investigative Site

Tianjin, 300480, China
Novartis Investigative Site

Zhenjiang, 310009, China
Novartis Investigative Site

Nice, Alpes Maritimes, 06189, France
Novartis Investigative Site

Dijon, Cote D Or, 21034, France
Novartis Investigative Site

Limoges, Haute Vienne, 87000, France
Novartis Investigative Site

Saint-Cloud, Hauts De Seine, 92210, France
Novartis Investigative Site

Rennes, Ille Et Vilaine, 35062, France
Novartis Investigative Site

Grenoble, Isere, 38028, France
Novartis Investigative Site

Lyon, Rhone, 69004, France
Novartis Investigative Site

Amiens, 80000, France
Novartis Investigative Site

Angers, 49055, France
Novartis Investigative Site

Argenteuil, 95107, France
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Avignon, 84082, France
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Besançon, 25030, France
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Bordeaux, 33076, France
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Bron, 69677, France
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Caen, 14021, France
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Le Mans, 72000, France
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Marseille, 13008, France
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Montpellier, 34070, France
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Montpellier, 34298, France
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Nantes, 44202, France
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Paris, 75013, France
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Paris, 75015, France
Novartis Investigative Site

Paris, 75231, France
Novartis Investigative Site

Paris, 75475, France
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Paris, 75970, France
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Pierre-Bénite, 69495, France
Novartis Investigative Site

Rouen, 76038, France
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Saint-Herblain, 44805, France
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Strasbourg, F 67085, France
Novartis Investigative Site

Toulouse, 31059, France
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Vandœuvre-lès-Nancy, 54519, France
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Villejuif, 94800, France
Novartis Investigative Site

Ravensburg, Baden-Wurttemberg, 88212, Germany
Novartis Investigative Site

Munich, Bavaria, 80637, Germany
Novartis Investigative Site

Munich, Bavaria, 81377, Germany
Novartis Investigative Site

Munich, Bavaria, 81675, Germany
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Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site

Cottbus, Brandenburg, 03048, Germany
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Frankfurt am Main, Hesse, 60431, Germany
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Georgsmarienhütte, Lower Saxony, 49124, Germany
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Hanover, Lower Saxony, 30177, Germany
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Essen, North Rhine-Westphalia, 45136, Germany
Novartis Investigative Site

Mönchengladbach, North Rhine-Westphalia, 41061, Germany
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Velbert, North Rhine-Westphalia, 42551, Germany
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Augsburg, 86150, Germany
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Bad Liebenwerda, 04924, Germany
Novartis Investigative Site

Berlin, 13125, Germany
Novartis Investigative Site

Bonn, 53111, Germany
Novartis Investigative Site

Bottrop, 46236, Germany
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Erlangen, 91054, Germany
Novartis Investigative Site

Essen, 45147, Germany
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Hamburg, 20357, Germany
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Kiel, 24105, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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Münster, 48149, Germany
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Regensburg, 93053, Germany
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Schweinfurt, 97422, Germany
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Tübingen, 72076, Germany
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Ulm, 89081, Germany
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Pécs, Baranya, 7623, Hungary
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Zalaegerszeg, Zala County, 8900, Hungary
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Budapest, H-1032, Hungary
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Budapest, H-1083, Hungary
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Budapest, H-1145, Hungary
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Kecskemét, 6001, Hungary
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Szeged, 6725, Hungary
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Szekszárd, 7100, Hungary
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Szombathely, H-9700, Hungary
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Tatabánya, H 2800, Hungary
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Wilton, Cork, T12 DC4A, Ireland
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County Limerick, V94 F858, Ireland
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Dublin, 533615, Ireland
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Dublin, D03 VX82, Ireland
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Dublin, DO4, Ireland
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Dublin, DUBLIN 9, Ireland
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Waterford, 48346, Ireland
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Ancona, AN, 60126, Italy
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Bergamo, BG, 24127, Italy
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Bologna, BO, 40138, Italy
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Catania, CT, 95123, Italy
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Milan, MI, 20133, Italy
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Rozzano, MI, 20089, Italy
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Palermo, PA, 90146, Italy
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Aviano, PN, 33081, Italy
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Roma, RM, 00128, Italy
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Candiolo, TO, 10060, Italy
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Naples, 80131, Italy
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Warsaw, Ul Roentgena 5, 02 781, Poland
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Bialystok, 15-027, Poland
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Gdynia, 81 519, Poland
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Gliwice, 44 101, Poland
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Grudziądz, 86 300, Poland
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Krakow, 31501, Poland
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Lodz, 90-338, Poland
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Lublin, 20 090, Poland
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Opole, 45 054, Poland
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Ostrołęka, 07-410, Poland
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Otwock, 05 400, Poland
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Wieliszew, 05-135, Poland
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Wroclaw, 02-781, Poland
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Cluj-Napoca, Cluj, 400015, Romania
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Craiova, Dolj, 200347, Romania
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Craiova, Dolj, 200535, Romania
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Bucharest, 011171, Romania
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Timișoara, 300425, Romania
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Kazan', Russian Federation, 420029, Russia
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Saint Petersburg, Sankt-Peterburg, 195271, Russia
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Chelyabinsk, 454087, Russia
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Kostroma, 156005, Russia
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Krasnoyarsk, 660022, Russia
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Moscow, 111123, Russia
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Moscow, 115522, Russia
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Moscow, 143423, Russia
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Nizhny Novgorod, 603137, Russia
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Novosibirsk, 630000, Russia
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Obninsk, 249036, Russia
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Omsk, 644013, Russia
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Orenburg, 460021, Russia
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Rostov-on-Don, 344037, Russia
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Ryazan, 390011, Russia
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Saint Petersburg, 191104, Russia
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Saint Petersburg, 197758, Russia
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Saint Petersburg, 198255, Russia
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Tyumen, 625041, Russia
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Ufa, 450054, Russia
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Yaroslavl, 150054, Russia
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Suwon, Gyeonggi-do, 16499, South Korea
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Gyeonggi-do, Korea, 10408, South Korea
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Incheon, Korea, 405 760, South Korea
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Seoul, Korea, 02841, South Korea
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Seoul, Korea, 03080, South Korea
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Cheongju-si, North Chungcheong, 28644, South Korea
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Seoul, Yangcheon Gu, 07985, South Korea
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Incheon, 22332, South Korea
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Seongnam Gyeonggi, 463-712, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
Novartis Investigative Site

Seoul, 06591, South Korea
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Ulsan, 44033, South Korea
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Elche, Alicante, 03203, Spain
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Granada, Andalusia, 18014, Spain
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Huelva, Andalusia, 21005, Spain
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Jaén, Andalusia, 23007, Spain
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Richmond, Virginia, 23230, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States
Yale University School Of Medicine

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

EARLY BREAST CANCER