New hope for keeping breast cancer at bay: major trial tests extra protection after surgery

NCT ID NCT05827081

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a medication called ribociclib to standard hormone therapy helps prevent breast cancer from returning after surgery. The trial will enroll 1,400 adults with high-risk, early-stage breast cancer that is hormone-positive and HER2-negative. Participants will take ribociclib pills daily for 3 years alongside their regular hormone therapy, with researchers tracking whether the cancer returns and monitoring side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Affiliated Oncologists IL
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Chicago, Illinois, 60415, United States

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Alaska Oncology and Hematology LLC
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Anchorage, Alaska, 99508, United States

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Bon Secours Virginia Health System
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Midlothian, Virginia, 23114, United States

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Boston Medical Center
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Boston, Massachusetts, 02118, United States

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CARTI Cancer Center
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Little Rock, Arkansas, 72205, United States

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Cancer Center of Kansas
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Wichita, Kansas, 67214-3728, United States

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Central Alabama Research
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Birmingham, Alabama, 35209, United States

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City of Hope National Medical
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Duarte, California, 91010, United States

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Clinical Research Alliance
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Lake Success, New York, 11042, United States

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Cone Health Cancer Center
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Greensboro, North Carolina, 27403, United States

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Consultants In Med Onco And Hema
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Drexel Hill, Pennsylvania, 19026, United States

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Dana Farber Cancer Institute
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Boston, Massachusetts, 02215, United States

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Duke Cancer Network
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Durham, North Carolina, 27710, United States

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El Paso Texas Oncology
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El Paso, Texas, 79902, United States

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Georgetown University Lombardi Cancer Center
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Washington D.C., District of Columbia, 20007-2197, United States

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HCA Midwest Division
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Kansas City, Missouri, 64132, United States

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Holy Cross Health
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Fort Lauderdale, Florida, 33308, United States

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Hope And Healing Care
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Hinsdale, Illinois, 60521, United States

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Intermountain Healthcare
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Billings, Montana, 59102, United States

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Investigative Clinical R of Indiana
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Indianapolis, Indiana, 46260, United States

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Jackson Oncology Associates
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Jackson, Mississippi, 39202, United States

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Kelsey Seybold Clinic
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Houston, Texas, 77025, United States

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Lexington Medical Center
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West Columbia, South Carolina, 29169, United States

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Maryland Oncology Hematology P A
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Silver Spring, Maryland, 20904, United States

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Memorial Cancer Institute
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Hollywood, Florida, 33021, United States

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Mercy Medical Center
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Baltimore, Maryland, 21202, United States

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Midwestern Reg MC COH Chicago
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Zion, Illinois, 60099, United States

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Minnesota Oncology Hematology P A
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Minneapolis, Minnesota, 55404, United States

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Mount Sinai School of Medicine
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New York, New York, 10029, United States

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Nebraska Cancer Specialists
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Omaha, Nebraska, 68154, United States

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Northwest Cancer Specialists
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Portland, Oregon, 97210, United States

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Northwest Medical Specialties
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Tacoma, Washington, 98405, United States

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Novartis Investigative Site
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Córdoba, X5004BAL, Argentina
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Gateshead, New South Wales, 2290, Australia
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Tiwi, Northern Territory, 810, Australia
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Clayton, Victoria, 3168, Australia
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East Melbourne, Victoria, 3002, Australia
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Victoria, British Columbia, V8R 6V5, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Oakville, Ontario, L6M1M1, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Beijing, Beijing Municipality, 100044, China
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Guangzhou, Guangdong, 510080, China
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Harbin, Heilongjiang, 150081, China
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Zhengzhou, Henan, 450003, China
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Zhengzhou, Henan, 450008, China
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Nanjing, Jiangsu, 210029, China
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Nanchang, Jiangxi, 330009, China
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Changchun, Jilin, 130021, China
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Jinan, Shandong, 250021, China
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Jinan, Shandong, 250117, China
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Jining, Shandong, 272000, China
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Chengdu, Sichuan, 610041, China
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Chengdu, Sichuan, 610072, China
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Ürümqi, Xinjiang, 830000, China
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Hangzhou, Zhejiang, 310006, China
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Hangzhou, Zhejiang, 310022, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100039, China
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Beijing, 100730, China
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Guangzhou, 510060, China
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Qingdao, 266000, China
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Shanghai, 200032, China
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Shijiazhuang, 050035, China
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Tianjin, 300480, China
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Munich, Bavaria, 81377, Germany
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Regensburg, Bavaria, 93053, Germany
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Weiden in Der Oberpfalz, Bavaria, 92637, Germany
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Langen, Hesse, 63225, Germany
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Hildesheim, Lower Saxony, 31134, Germany
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Bergisch Gladbach, North Rhine-Westphalia, 51465, Germany
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Bielefeld, North Rhine-Westphalia, 33604, Germany
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Düsseldorf, North Rhine-Westphalia, 40225, Germany
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Essen, North Rhine-Westphalia, 45136, Germany
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Mönchengladbach, North Rhine-Westphalia, 41061, Germany
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Velbert, North Rhine-Westphalia, 42551, Germany
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Dresden, Saxony, 01307, Germany
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Lübeck, Schleswig-Holstein, 23563, Germany
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Augsburg, 86150, Germany
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Augsburg, 86179, Germany
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Berlin, 10967, Germany
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Berlin, 13125, Germany
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Bottrop, 46236, Germany
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Böblingen, 71032, Germany
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Dessau, 06847, Germany
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Erlangen, 91054, Germany
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Essen, 45147, Germany
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Hamburg, 20246, Germany
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Kiel, 24105, Germany
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Leipzig, 04277, Germany
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Mainz, 55131, Germany
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München, 80637, Germany
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Ravensburg, 88214, Germany
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Hong Kong, 999077, Hong Kong
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Kowloon, 999999, Hong Kong
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Tuenmen, 999077, Hong Kong
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Hyderabad, Andhra Pradesh, 500034, India
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Bangalore, Karnataka, 560017, India
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Mumbai, Maharashtra, 400 012, India
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Pune, Maharasthra, 411028, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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Bhubaneshwar, Odisha, 751007, India
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Chennai, Tamil Nadu, 600 035, India
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Kolkata, West Bengal, 700054, India
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Ahmedabad, 380054, India
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Beersheba, 8457108, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 6423906, Israel
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Alc Cuahutemoc, Mexico City, 06720, Mexico
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Tlalpan, Mexico City, 14080, Mexico
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Monterrey, Nuevo León, 64460, Mexico
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Coimbra, 3000-075, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1649-035, Portugal
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Porto, 4100-180, Portugal
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Porto, 4200 319, Portugal
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Porto, 4200-072, Portugal
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Bundang Gu, Gyeonggi-do, 13620, South Korea
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Gyeonggi-do, Korea, 10408, South Korea
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Incheon, Korea, 405 760, South Korea
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Seoul, Korea, 02841, South Korea
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Seoul, Korea, 03080, South Korea
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Seoul, Yangcheon Gu, 07985, South Korea
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Seongnam Gyeonggi, 463-712, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Hualien City, 970, Taiwan
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Kaohsiung City, 80756, Taiwan
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Tainan, 71004, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 114, Taiwan
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Sakarya, Adapazari, 54290, Turkey (Türkiye)
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Ankara, Bilkent-Cankaya, 06800, Turkey (Türkiye)
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Istanbul, Fatih, 34098, Turkey (Türkiye)
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Istanbul, Kadikoy, 34722, Turkey (Türkiye)
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Izmir, Karsiyaka, 35575, Turkey (Türkiye)
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Denizli, Kinikli, 20070, Turkey (Türkiye)
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Antalya, Konyaalti, 07070, Turkey (Türkiye)
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Istanbul, Sariyer, 34457, Turkey (Türkiye)
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Ankara, Sihhiye-Altindag, 06230, Turkey (Türkiye)
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Diyarbakır, Sur, 21280, Turkey (Türkiye)
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Istanbul, Uskudar, 34662, Turkey (Türkiye)
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Ankara, Yenimahalle, 06200, Turkey (Türkiye)
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Ankara, Yenimahalle, 06500, Turkey (Türkiye)
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Adana, Yuregir, 01230, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Istanbul, 34147, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kecioren Ankara, 06010, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Samsun, 55200, Turkey (Türkiye)
Ocala Research Institute, Inc
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Ocala, Florida, 34474, United States

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Onco Inst of Hope and Innovation
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Cerritos, California, 90703, United States

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Oncology Associates of Oregon PC
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Eugene, Oregon, 97401-8122, United States

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Oregon Oncology Specialists Salem
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Salem, Oregon, 97301, United States

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Palo Alto Medical Foundation
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Mountain View, California, 94040, United States

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Pan Oncology
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Rio Piedras, 00935, Puerto Rico

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Presbyterian Medical Group
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Albuquerque, New Mexico, 87110, United States

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Providence Medical Foundation
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Fullerton, California, 92835, United States

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Providence Regional Cancer System
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Lacey, Washington, 98503, United States

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Queens Cancer Center of Queens Hospital
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Jamaica, New York, 11432, United States

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Renown Regional Medical Center
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Reno, Nevada, 89502, United States

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Rhode Island Hospital
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Providence, Rhode Island, 02903, United States

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Rocky Mountain Cancer Centers
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Denver, Colorado, 80218, United States

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Sanford USD Medical Center
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Sioux Falls, South Dakota, 57104, United States

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Sarah Cannon Research Institute
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Nashville, Tennessee, 37203, United States

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School Of Medicine
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Sacramento, California, 95817, United States

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Summit Cancer Care PC
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Savannah, Georgia, 31405, United States

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Summit Health
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Florham Park, New Jersey, 07932, United States

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Sutter Inst Medical Research
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Sacramento, California, 95816-5199, United States

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Texas Oncology P A Plano East
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Plano, Texas, 75075, United States

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Texas Oncology PA Tyler
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Tyler, Texas, 75702, United States

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The Valley Hospital
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Ridgewood, New Jersey, 07450, United States

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UC Irvine Medical Center
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Orange, California, 92868, United States

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Univ of Pittsburg Med Ctr Pinnacle
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Harrisburg, Pennsylvania, 17109, United States

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University of Iowa Health Care
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Waukee, Iowa, 50263, United States

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University of Kansas Cancer Center
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Westwood, Kansas, 66205, United States

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University of Texas
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Houston, Texas, 77030-4099, United States

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Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

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WA Uni School Of Med
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St Louis, Missouri, 63110, United States

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Washington Hospital Center
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Washington D.C., District of Columbia, 20010, United States

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Western Reg MC-COH Phoenix
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Goodyear, Arizona, 85338, United States

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Willis-Knighton Cancer Center
RECRUITING

Shreveport, Louisiana, 71103, United States

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Conditions

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EARLY BREAST CANCER