New hope for advanced breast cancer patients after standard treatment fails

NCT ID NCT05646862

Summary

This study is for people with a specific type of advanced breast cancer that has a genetic change called PIK3CA and has continued to grow despite standard hormone-based therapy. It aims to see if a new drug combination (inavolisib + fulvestrant) works better and is safer than an existing combination (alpelisib + fulvestrant) at controlling the cancer. About 420 participants will be randomly assigned to receive one of the two treatment combinations.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. S. Anna e San Sebastiano

    Caserta, Campania, 81100, Italy

  • ARKE Estudios Clínicos S.A. de C.V.

    Mexico City, Mexico CITY (federal District), 06700, Mexico

  • Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

    Morelia, 58260, Mexico

  • Arthur J.E. Child Comprehensive Cancer Center-Calgary

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asante Rogue Regional Medical Center

    Medford, Oregon, 97504-8332, United States

  • BC Cancer ? Vancouver

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Basingstoke and North Hampshire Hospital

    Basingstoke, RG24 9NA, United Kingdom

  • Bendigo Cancer Centre

    Bendigo, Victoria, 3550, Australia

  • Blackpool Victoria Hospital

    Blackpool, FY3 8NR, United Kingdom

  • Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

    Mönchengladbach, 41061, Germany

  • CENEIT Oncologicos

    Mexico City, 03100, Mexico

  • CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica

    San Juan, J5400DIL, Argentina

  • CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • COI Centro Oncologico Internacional Santa Fe

    Mexico City, Mexico CITY (federal District), 01330, Mexico

  • Cancer & Hematology Centers of Western Michigan

    Grand Rapids, Michigan, 49503, United States

  • Cancer Blood and Specialty Clinic

    Los Alamitos, California, 90720, United States

  • Centre Eugene Marquis

    Rennes, 35042, France

  • Centre Hospitalier de La Cote Basque

    Bayonne, 64109, France

  • Centre Hospitalier de l'Universite de Montreal (CHUM)

    Montreal, Quebec, H2X 0C2, Canada

  • Centre Leon Berard

    Lyon, 69008, France

  • Centro Oncologico Korben

    Ciudad Autonoma Buenos Aires, C1426AGE, Argentina

  • Centro de Investigaciones Médicas y Desarrollo LC S.R.L

    Buenos Aires, C1113AAE, Argentina

  • Centrum Onkologii im. Prof. Franciszka ?ukaszczyka

    Bydgoszcz, 85-796, Poland

  • Chang Gung Memorial Hosipital at Linkou

    Taoyuan, 333, Taiwan

  • China Medical University Hospital

    Taichung, 404, Taiwan

  • Churchill Hospital

    Oxford, OX3 7LE, United Kingdom

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Clinica Viedma S.A.

    Viedma, R8500ACE, Argentina

  • Clinique Ste-Elisabeth

    Namur, 5000, Belgium

  • Cliniques Universitaires St-Luc

    Brussels, 1200, Belgium

  • Coffs Harbour Health Campus

    Coffs Harbour, New South Wales, 2450, Australia

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139, Australia

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dicle University Faculty of Medicine

    Diyarbakır, 21280, Turkey (Türkiye)

  • Ege Uni Medical Faculty Hospital

    Izmir, 35100, Turkey (Türkiye)

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • First Affiliated Hospital of Medical College of Xi'an Jiaotong University

    Xi'an, 710061, China

  • Fundacion CORI para la Investigacion y Prevencion del Cancer

    La Rioja, F5300COE, Argentina

  • GHdC Site Les Viviers

    Charleroi, 6000, Belgium

  • Gangnam Severance Hospital

    Seoul, 06273, South Korea

  • Gosford Hospital

    Gosford, New South Wales, 2250, Australia

  • Goztepe Prof.Dr. Suleyman Yalcin City Hospital

    Kadiköy, 34722, Turkey (Türkiye)

  • Grady Health System

    Atlanta, Georgia, 30303, United States

  • Guangdong Provincial People's Hospital

    Guangzhou, 510180, China

  • Gulhane Training and Applicaton Hospital

    Ankara, 06010, Turkey (Türkiye)

  • Hacettepe Uni Medical Faculty Hospital

    Sihhiye/Ankara, 06230, Turkey (Türkiye)

  • Harbin Medical University Tumor Hospital

    Harbin, 150049, China

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Hosp Provincial D. Centenarios

    Rosario, S2002KDS, Argentina

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Regional Universitario Carlos Haya

    Málaga, 29011, Spain

  • Hospital San Pedro De Alcantara

    Cáceres, 10003, Spain

  • Hospital Santa Cruz / Centro de Oncologia D'Or

    Curitiba, Paraná, 80420-090, Brazil

  • Hospital Sírio-Libanês

    São Paulo, São Paulo, 01308-050, Brazil

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario de Canarias

    San Cristóbal de La Laguna, Tenerife, 38320, Spain

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital do Cancer de Pernambuco - HCP

    Recife, Pernambuco, 50040-000, Brazil

  • Hubei Cancer Hospital

    Wuhan, 430079, China

  • Hôpital du Sacré-Coeur de Montreal

    Montreal, Quebec, H4J 1C5, Canada

  • ICM

    Montpellier, 34298, France

  • ICO L'Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

    Meldola, Emilia-Romagna, 47014, Italy

  • IUCT Oncopole

    Toulouse, 31100, France

  • Icon Cancer Care Wesley

    Auchenflower, Queensland, 4066, Australia

  • Inha University Hospital

    Incheon, 22332, South Korea

  • Instituto D?Or de Pesquisa e Ensino ? Hospital Esperança Recife

    Recife, Pernambuco, Brazil

  • Instituto Nacional de Cancerologia

    Distrito Federal, 14080, Mexico

  • Instituto de Oncología de Rosario

    Rosario, S2000KZE, Argentina

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Jiangsu Cancer Hospital

    Nanjing, 211100, China

  • Juravinski Hospital

    Hamilton, Ontario, L8V 5C2, Canada

  • Katip Celebi University Ataturk Training and Research Hospital

    Izmir, 35360, Turkey (Türkiye)

  • Kinghorn Cancer Centre

    Darlinghurst, New South Wales, 2010, Australia

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404, South Korea

  • Liga Norte Riograndense Contra O Câncer

    Natal, Rio Grande do Norte, 59040150, Brazil

  • Los Angeles Cancer Network

    Los Angeles, California, 90017-4803, United States

  • MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie

    Rzeszów, 35-021, Poland

  • Maidstone & Tonbridge Wells Hospital

    Maidstone, ME16 9QQ, United Kingdom

  • Mammazentrum Hamburg am Krankenhaus Jerusalem

    Hamburg, 20357, Germany

  • Marmara Uni Faculty of Medicine

    Istanbul, 34890, Turkey (Türkiye)

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical Oncology Centre of Rosebank

    Johannesburg, 2196, South Africa

  • Medipol Mega Üniversite Hastanesi Göztepe

    Istanbul, 34214, Turkey (Türkiye)

  • Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie

    Hanover, 30625, Germany

  • Memorial Ankara Hastanesi

    Ankara, 06520, Turkey (Türkiye)

  • Midtown West Medical

    Atlanta, Georgia, 30318, United States

  • Minnesota Oncology Hematology

    Saint Paul, Minnesota, 55102, United States

  • Mount Vernon & Watford Hospital Trust

    Northwood, HA6 2RN, United Kingdom

  • NUPEC

    Belo Horizonte, Minas Gerais, 30210-090, Brazil

  • Narodowy Instytut Onkologii Odzia? w Gliwicach

    Gliwice, 44-102, Poland

  • Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie

    Warsaw, 02-781, Poland

  • National Cancer Center

    Goyang-si, 10408, South Korea

  • National Cheng Kung University Hospital

    Tainan, 70457, Taiwan

  • National Taiwan University Hospital

    Zhongzheng Dist., 10048, Taiwan

  • Nationales Centrum für Tumorerkrankungen (NCT)

    Heidelberg, 69120, Germany

  • OncoMed

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Ospedale San Raffaele

    Milan, Lombardy, 20132, Italy

  • Ospedale Santa Chiara

    Trento, Trentino-Alto Adige, 38100, Italy

  • Panamerican Clinical Research S.A de C.V.

    Guadalajara, Jalisco, 44670, Mexico

  • Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

    Freiburg im Breisgau, 79110, Germany

  • Princess Alexandra Hospital

    Harlow, CM20 1QX, United Kingdom

  • Przychodnia Lekarska KOMED, Roman Karaszewski

    Konin, 62-500, Poland

  • RENATI INNOVATION S.A.P.I. de C.V

    Guadalajara, Jalisco, 44680, Mexico

  • Richards Bay Oncology Centre

    KwaZulu Natal, 3900, South Africa

  • Rocky Mountain Cancer Centers

    Denver, Colorado, 80220, United States

  • Royal Hampshire County Hospital

    Winchester, SO22 5DG, United Kingdom

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Seoul St Mary's Hospital

    Seoul, 06591, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Sichuan Provincial Cancer Hospital

    Chengdu, 610041, China

  • Sir Charles Gairdner Hospital

    Perth, Western Australia, 6009, Australia

  • Sir Run Run Shaw Hospital Zhejiang University

    Hangzhou, 310016, China

  • St Bartholomew's Hospital

    London, EC1M 6BQ, United Kingdom

  • St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise

    Paderborn, 33098, Germany

  • Sun yat-sen University Cancer Center

    Guangzhou, 510060, China

  • Szpital Uniwersytecki w Krakowie

    Krakow, 31-501, Poland

  • Szpital Wojewódzki im. Miko?aja Kopernika

    Koszalin, 75-581, Poland

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Texas Oncology - Dallas Presbyterian Hospital

    Dallas, Texas, 75231, United States

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • The Moncton Hospital

    Moncton, New Brunswick, E1C 6Z8, Canada

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario, K1Y 4E9, Canada

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, 310009, China

  • The Second Affiliated Hospital to Nanchang University

    Nanchang, 330006, China

  • Tianjin Cancer Hospital

    Tianjin, 300000, China

  • Trakya University Medical Faculty

    Edirne, 22030, Turkey (Türkiye)

  • UC Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • UZ Antwerpen

    Edegem, 2650, Belgium

  • UZ Gent

    Ghent, 9000, Belgium

  • UZ Leuven Gasthuisberg

    Leuven, 3000, Belgium

  • Uniklinik RWTH Aachen Klinik für Gynäkologie und Geburtsmedizin

    Aachen, 52074, Germany

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430023, China

  • Universitätsklinikum Essen

    Essen, 45122, Germany

  • Universitätsmedizin Göttingen Georg-August-Universität

    Göttingen, 37075, Germany

  • Veterans General Hospital - Taichung

    Xitun Dist., 40705, Taiwan

  • Western General Hospital

    Edinburgh, EH4 2XU, United Kingdom

  • Winship Cancer Institute at Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342, United States

  • Zhejiang Cancer Hospital

    Zhejiang, 310022, China

Conditions

Explore the condition pages connected to this study.