New drug duos battle tough breast cancer

NCT ID NCT03330847

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding one of two experimental drugs (ceralasertib or adavosertib) to an existing cancer drug (olaparib) works better than olaparib alone for people with metastatic triple-negative breast cancer. It involves about 273 patients whose cancer has worsened after 1-2 prior treatments. The trial groups patients based on specific genetic changes in their tumors to see which combinations might help control cancer growth for longer.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35205, United States
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Anchorage, Alaska, 99508, United States
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Gilbert, Arizona, 85234, United States
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Aurora, Colorado, 80045, United States
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New Haven, Connecticut, 06511, United States
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Chicago, Illinois, 60637, United States
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Munster, Indiana, 46321, United States
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Hazard, Kentucky, 41701, United States
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Louisville, Kentucky, 40207, United States
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Towson, Maryland, 21204, United States
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Brick, New Jersey, 08724, United States
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East Setauket, New York, 11733, United States
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Lake Success, New York, 11042, United States
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Mineola, New York, 11501, United States
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Mount Kisco, New York, 10549, United States
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Stony Brook, New York, 11794, United States
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Cincinnati, Ohio, 45219, United States
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Knoxville, Tennessee, 37909, United States
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Seattle, Washington, 98104, United States
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Milwaukee, Wisconsin, 53212, United States
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Brasschaat, 2930, Belgium
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Brussels, 1000, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Ottignies, 1340, Belgium
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Wilrijk, 2610, Belgium
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Calgary, Alberta, T2N 4N2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Brno, 625 00, Czechia
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Olomouc, 775 20, Czechia
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Prague, 180 81, Czechia
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Angers, 49055, France
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Besançon, 25030, France
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Bordeaux, 33076, France
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Caen, 14076, France
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Lille, 59000, France
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Lyon, 69373, France
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Marseille, 13273, France
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Montpellier, 34298, France
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Nantes, 44202, France
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Rennes, 35000, France
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Saint-Herblain, 44805, France
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Tours, 37044, France
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Villejuif, 94805, France
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Dresden, 1307, Germany
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Frankfurt am Main, 60431, Germany
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Hamburg, 20357, Germany
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Hanover, 30559, Germany
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Leipzig, 04103, Germany
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München, 81675, Germany
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Witten, 58452, Germany
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Cork, T12 DV56, Ireland
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Dublin, Ireland
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Ancona, 60126, Italy
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Bologna, 40138, Italy
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Brescia, 25124, Italy
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Cona, 44124, Italy
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Genova, 16128, Italy
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Lecco, 23900, Italy
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Macerata, 62100, Italy
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Meldola, 47014, Italy
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Messina, 98125, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Novara, 28100, Italy
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Parma, 43126, Italy
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Pavia, 27100, Italy
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Pisa, 56126, Italy
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Roma, 00128, Italy
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Rozzano, 20089, Italy
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Siena, 53100, Italy
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Torino, 10123, Italy
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Breda, 4819 EV, Netherlands
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Rotterdam, 3015 GD, Netherlands
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The Hague, 2545 CH, Netherlands
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Dąbrowa Górnicza, 41-300, Poland
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Gdansk, 80-952, Poland
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Gdynia, 81-519, Poland
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Grzepnica, 72-003, Poland
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Krakow, 31-531, Poland
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Lodz, 91-211, Poland
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Olsztyn, 10-228, Poland
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Poznan, 60-192, Poland
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Warsaw, 02-781, Poland
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Wroclaw, 53-413, Poland
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Lisbon, 1400-038, Portugal
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Lisbon, 1769-001, Portugal
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Loures, 2674-514, Portugal
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Porto, 4099-001, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Cheongju-si, 28644, South Korea
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Daegu, 41404, South Korea
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Goyang-si, 410-769, South Korea
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Incheon, 405-760, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 02841, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Cáceres, 10003, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Palma de Mallorca, 07120, Spain
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San Sebastián, 20014, Spain
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Sant Cugat del Vallès, 08190, Spain
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Seville, 41009, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Vigo, 36312, Spain
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Zaragoza, 50009, Spain
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Changhua, 500, Taiwan
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Kaohsiung Hsien, 83342, Taiwan
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Taichung, 40447, Taiwan
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Taipei, 10048, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan District, 333, Taiwan
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Aberdeen, AB25 2ZN, United Kingdom
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Bristol, BS1 2NT, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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Durham, DH1 5TW, United Kingdom
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Edinburgh, EH4 2XR, United Kingdom
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Leicester, LE1 5WW, United Kingdom
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London, SE1 9RT, United Kingdom
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London, W1G 6AD, United Kingdom
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London, W1T 7HA, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Southampton, SO16 6YD, United Kingdom

Conditions

Explore the condition pages connected to this study.

METASTATIC TRIPLE NEGATIVE BREAST CANCER