New trial burns tumors from inside to fight bile duct cancer

NCT ID NCT07235007

Recruiting now Disease control Sponsor: Aichi Medical University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a procedure called endobiliary radiofrequency ablation (EB-RFA) can help people with advanced bile duct cancer live longer. EB-RFA uses a catheter to deliver heat directly to the tumor inside the bile duct. Half of the 120 participants will receive EB-RFA plus a plastic stent, while the other half get only the stent. Everyone also receives standard chemotherapy and immunotherapy. The main goal is to see if the added ablation improves overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endobiliary radiofrequency ablation (EB-RFA) using a catheter device, plus a plastic biliary stent
What this could lead to: If successful, this could extend survival for people with advanced bile duct cancer by combining a local tumor-burning procedure with standard chemotherapy and immunotherapy.
What could go wrong: This is an early-phase trial with only 120 participants, so results may not apply to everyone. The procedure carries risks like bile duct injury or infection, and the added benefit over standard care is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Biliary Tract Neoplasms cholangiocarcinoma extrahepatic bile duct carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRAHEPATIC CHOLANGIOCARCINOMA

Contacts and locations

Locations

Aichi Medical University
RECRUITING

Aichi, Japan
Gangnam Severance Hospital, Yonsei University College of Medicine
RECRUITING

Seoul, South Korea
Gifu University Hospital
RECRUITING

Gifu, Japan
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
RECRUITING

Seoul, South Korea
Nagoya City University Hospital
RECRUITING

Aichi, Japan
Nagoya City University Midori Municipal Hospital
RECRUITING

Aichi, Japan
Pusan National University Hospital
RECRUITING

Busan, South Korea
Severance Hospital, Yonsei University College of Medicine
RECRUITING

Seoul, South Korea

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