Could a malaria drug help fight brain tumors in kids?
NCT ID NCT04201457
First seen Feb 03, 2026 · Last updated May 15, 2026 · Updated 10 times
Summary
This study tests whether adding hydroxychloroquine (a malaria drug) to targeted cancer drugs (dabrafenib and/or trametinib) can help children and young adults with certain brain tumors that have come back or not responded to previous treatment. Participants must have tumors with specific genetic changes (BRAF V600 mutation or BRAF fusion/duplication) or have neurofibromatosis type 1. The goal is to find the best dose and see if the combination slows tumor growth.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90026, United States
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Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010-2970, United States
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Cincinnati Children Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Lurie Children's Hospital-Chicago
Chicago, Illinois, 60614, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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National Cancer Institute Pediatric Oncology Branch
Bethesda, Maryland, 20892, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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St. Jude Children Research Hospital
Memphis, Tennessee, 38105, United States
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Texas Children's Cancer Center
Houston, Texas, 77030, United States
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University of Florida
Gainesville, Florida, 32608, United States
Conditions
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