Mind over mood: MRI brain training targets Depression's repetitive thoughts
NCT ID NCT05933148
First seen Jun 18, 2026 · Last updated Jun 22, 2026 · Updated 1 time
Summary
This study tests whether real-time brain imaging (fMRI) can help people with major depressive disorder learn to reduce rumination—repetitive negative thinking. Participants will receive either real or sham neurofeedback while in an MRI scanner, aiming to strengthen a specific brain connection linked to rumination. The trial includes 80 adults aged 18-65 with current depression.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Icahn School Of Medicine at Mount Sinai
New York, New York, 10029, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
real-time fMRI neurofeedback (brain training using MRI)
What this could lead to
If it works, this could offer a new drug-free way to reduce repetitive negative thinking in depression, potentially lowering relapse risk.
What could go wrong
This is an early, small study testing a complex brain-training technique. It may not work for everyone, and the effects might not last. The trial is currently suspended.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.