Scientists test new combo to fight deadly brain cancer
NCT ID NCT00268385
Summary
This early-stage study is testing a combination of two chemotherapy drugs, vorinostat and temozolomide, in adults with aggressive brain tumors called malignant gliomas. The main goals are to find the safest dose of the drug combination and to understand its side effects. Researchers hope that adding vorinostat will make the tumor cells more sensitive to temozolomide, potentially killing more cancer cells.
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Contacts and locations
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Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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National Cancer Institute Neuro-Oncology Branch
Bethesda, Maryland, 20892, United States
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UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
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UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
Conditions
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