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Could a botox shot in the throat restore swallowing after stroke or Parkinson's?

NCT ID NCT04695600

Recruiting now Disease control Sponsor: All India Institute of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial investigates whether injecting Botox into the upper throat muscle (cricopharyngeus) can ease swallowing problems in people with conditions like stroke, multiple sclerosis, or Parkinson's. The muscle normally relaxes during swallowing but can become too tight in these disorders. Researchers will compare Botox injections to a placebo in 100 participants, measuring improvements in swallowing function after three weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Botulinum toxin A (Botox)
What this could lead to
If effective, Botox injections could offer a non-surgical treatment for swallowing difficulties caused by a tight throat muscle.
What could go wrong
This is an early combined Phase 2/3 trial with 100 participants. Previous studies have been small and inconclusive, so results may not confirm benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Deglutition Disorders retrograde cricopharyngeus dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRICOPHARYNGEUS MUSCLE DYSFUNCTION OROPHARYNGEAL DYSPHAGIA TRANSFER DYSPHAGIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • All India Institute of Medical Sciences, New Delhi

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110029, India

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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