Botox for stress? tiny study tests the idea

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subjects capable of giving informed consent in the English language 2. Females 18-65 years of age 3. Perceived Stress Scale (PSS) ≥ 14 at screening. 4. Participants who have been toxin-naive for ≥1 year (i.e. onabotulinumtoxinA (BOTOX®), alternatives, or its derivatives) 5. Female subjects willing to minimize the risk of inducing pregnancy for the duration of clinical study 6. Subjects in good physical and mental health and not on any prescription psychiatric medications 7. Subjects willing to not undergo any other aesthetic or skin treatments for the duration of the study Exclusion Criteria: 1. Participants with history of facial (including periorbital) surgery within the last 12 months 2. Use of neuromodulators in the past ≤ 12 months 3. History or known alcohol and/or illicit drug abuse 4. Participants with psychiatric diagnosis 5. Body Mass Index (BMI) at Screening ≥ 30 kg/m2. 6. Participants with metabolic disorders (e.g., hypothyroidism and hyperparathyroidism) 7. Undiagnosed, unstable, or preexisting conditions that in the opinion of the investigators, would interfere with the course and conduct of the study. These include but are not limited to inflammatory disorders, diseases that affect muscles and/or nerves such as myasthenia gravis and Lambert-Eaton syndrome, high blood pressure, heart disease, and/or stroke that could result in a life-threatening response when treated with BOTOX® or placebo. 8. Participant has any laboratory abnormality (found on screening) that, in the opinion of the investigators, is clinically significant, has not resolved at baseline and could jeopardize or would compromise the participant's ability to participate in this study. 9. Prior use of isotretinoin 10. Active skin disease or infection at or near injection sites 11. Active use of tobacco or nicotine products in any form via any route (e.g. inhalation, ingestion, absorption) 12. Chronic marijuana or tetrahydrocannabinol exposure 13. If the investigators feel that the subject is not a good candidate for the study 14. Females of childbearing potential not using a reliable means of contraception 15. Female subjects must not be breastfeeding 16. Any known previous hypersensitivity reactions to BOTOX® 17. Current or recent (within therapeutic window) use of neuromuscular medications that may pose additional risk with treatment with BOTOX®, such as but not limited to amino-glycosides and anticholinergic drugs