Drug interaction study tests liver enzyme effects on cancer treatment
NCT ID NCT05072106
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how bosentan, a drug that affects liver enzymes, changes the levels of the cancer drug lurbinectedin in the blood. Eleven adults with advanced solid tumors received lurbinectedin alone and with bosentan. The goal was to see if bosentan alters how the body processes lurbinectedin, which could guide future dosing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lurbinectedin and bosentan
What this could lead to
If successful, this could help doctors understand how to safely combine lurbinectedin with other drugs that affect liver enzymes.
What could go wrong
This is a very small, early-phase study focused on drug levels, not treatment effectiveness. Results may not apply to larger populations or show any benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fundación Jiménez Diaz
Madrid, 28040, Spain
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Hospital de Sanchinarro
Madrid, 28050, Spain