New booster shot shows promise for protecting vulnerable patients against COVID-19

NCT ID NCT05303402

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 25 times

Summary

This study tested an extra dose of the PHH-1V COVID-19 vaccine in 241 adults with weakened immune systems (due to HIV, kidney disease, or autoimmune conditions) who had already received other COVID-19 vaccines. The goal was to see if the booster increased their antibody levels against different virus variants and was safe. Results help determine if this vaccine can better protect immunocompromised people.

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Contacts and locations

Locations

  • Ankara University Medical Faculty Hospitals

    Ankara, Ankara, 06620, Turkey (Türkiye)

  • Hacettepe University Medical Faculty Hospitals

    Ankara, Ankara, 06230, Turkey (Türkiye)

  • Hospital Clínic de Barcelona

    Barcelona, Barcelona, 08036, Spain

  • Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Hospital Josep Trueta

    Girona, Girona, 17001, Spain

  • Koc University Hospital

    Istanbul, Istanbul, 34010, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.