Half-Matched bone marrow transplant offers new hope for severe sickle cell patients

NCT ID NCT03240731

Completed Disease control Sponsor: Centre Hospitalier Intercommunal Creteil Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 20 times

Summary

This study tested a bone marrow transplant from a half-matched (haploidentical) donor in 25 people aged 13 to 40 with severe sickle cell disease. The goal was to replace the faulty blood cells with healthy donor cells using a gentle chemotherapy preparation and a drug to prevent graft-versus-host disease. The approach aims to control the disease long-term, though patients may need ongoing monitoring and medication.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

CHU Henri-Mondor

Créteil, 94000, France
CHU La Timone

Marseille, France
CHU Strasbourg

Strasbourg, France
Hospital Necker

Paris, France
Hospital Robert-Debré

Paris, France
Saint-Louis hospital

Paris, France
intercommunal hospital of Créteil

Créteil, 94000, France

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE