New combo shows promise for melanoma patients who failed standard treatment
NCT ID NCT04570332
First seen Dec 08, 2025 · Last updated Apr 30, 2026 · Updated 19 times
Summary
This study tested a new drug combination for people with advanced melanoma that had stopped responding to standard immunotherapy. The treatment involved injecting BO-112 directly into tumors along with pembrolizumab given through a vein. The goal was to see if the combination could shrink tumors and be safe for the 42 participants enrolled.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centre Hospitalier Universitaire de Bordeaux
Bordeaux, France
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Centre Hospitalier Universitaire de Grenoble
Grenoble, France
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Centre Hospitalier Universitaire de Nantes
Nantes, France
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Centre Hospitalier Universitaire de Nice
Nice, France
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Clínica Universidad de Navarra
Pamplona, Spain
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H. General Universitario de Valencia
Valencia, Spain
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H. Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain
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H. Universitari Quirón Dexeus
Barcelona, Spain
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Hopital Lyon Sud
Lyon, France
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Hospital Clara Campal - HM Sanchinarro
Madrid, Spain
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Hospital Clinic de Barcelona
Barcelona, Spain
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Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, Spain
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Hospital Universitario 12 de Octubre
Madrid, Spain
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Hospital Universitario Virgen Macarena
Seville, Spain
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Hospital Universitario de Canarias
San Cristóbal de La Laguna, Tenerife, Spain
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Hôpital Ambroise-Paré
Paris, France
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Institut Gustave Roussy
Paris, France
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MD Anderson Cancer Center
Madrid, Spain
Conditions
Explore the condition pages connected to this study.