Bladder cancer breakthrough? immunotherapy and radiation join forces before surgery

NCT ID NCT05241340

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 34 times

Summary

This study tests a new approach for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. It combines an immunotherapy drug (sasanlimab) with targeted radiation to boost the immune system's ability to fight the tumor before surgical removal of the bladder. The goal is to see if this combination is safe and can lead to a complete disappearance of cancer in the removed bladder tissue.

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Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77006, United States

Conditions

Explore the condition pages connected to this study.