New Bladder-Sparing cancer fight: immune drug challenges chemo

NCT ID NCT06770582

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is for people with a specific type of high-grade bladder cancer that has not spread into the muscle wall. It compares two different treatment combinations, both given with radiation therapy. One group gets a standard chemotherapy drug, while the other gets an immunotherapy drug called pembrolizumab. The main goal is to see which approach is better at controlling the cancer while allowing patients to keep their bladder.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AIS Cancer Center at San Joaquin Community Hospital
RECRUITING

Bakersfield, California, 93301, United States

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BJC Outpatient Center at Sunset Hills
RECRUITING

Sunset Hills, Missouri, 63127, United States

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Bon Secours Cancer Institute at Reynolds Crossing
RECRUITING

Richmond, Virginia, 23230, United States

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Bon Secours Memorial Regional Medical Center
RECRUITING

Mechanicsville, Virginia, 23116, United States

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Bon Secours Saint Francis Medical Center
RECRUITING

Midlothian, Virginia, 23114, United States

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Bon Secours Saint Mary's Hospital
RECRUITING

Richmond, Virginia, 23226, United States

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Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States

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Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

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Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

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Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States

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Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States

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Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

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Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

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Emory Proton Therapy Center
RECRUITING

Atlanta, Georgia, 30308, United States

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Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States

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Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States

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Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

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Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

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Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States

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Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

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Essentia Health Saint Mary's Medical Center
RECRUITING

Duluth, Minnesota, 55805, United States

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Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

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Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

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Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

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Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

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Grady Health System
RECRUITING

Atlanta, Georgia, 30303, United States

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Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States

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Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Lake Regional Hospital
RECRUITING

Osage Beach, Missouri, 65065, United States

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Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

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Louisiana Hematology Oncology Associates LLC
RECRUITING

Baton Rouge, Louisiana, 70809, United States

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Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States

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Mary Bird Perkins Cancer Center - Gonzales
RECRUITING

Gonzales, Louisiana, 70737, United States

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Mary Bird Perkins Cancer Center - Metairie
RECRUITING

Metairie, Louisiana, 70002, United States

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Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States

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McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States

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Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States

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Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Mercy Cancer Center-West Lakes
RECRUITING

Clive, Iowa, 50325, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

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Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

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Michigan Healthcare Professionals Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States

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Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

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Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States

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Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States

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Mount Sinai Medical Center
SUSPENDED

Miami Beach, Florida, 33140, United States
Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

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Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States

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Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States

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Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

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Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States

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Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Shaw Cancer Center
RECRUITING

Edwards, Colorado, 81632, United States

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Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

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The Iowa Clinic PC
RECRUITING

West Des Moines, Iowa, 50266, United States

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Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

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Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States

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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States

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Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

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Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States

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UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States

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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States

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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States

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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States

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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States

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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States

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UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States

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UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States

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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States

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UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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UPMC Hillman Cancer Center - New Castle
RECRUITING

New Castle, Pennsylvania, 16105, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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UPMC Washington Hospital Radiation Oncology
RECRUITING

Washington, Pennsylvania, 15301, United States

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UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States

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UPMC-Saint Margaret
RECRUITING

Pittsburgh, Pennsylvania, 15215, United States

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UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

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University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States

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University of Kansas Cancer Center - Briarcliff
RECRUITING

Kansas City, Missouri, 64116, United States

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University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States

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University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States

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University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States

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University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States

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University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States

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University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States

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VCU Community Memorial Health Center
RECRUITING

South Hill, Virginia, 23970, United States

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VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

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West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

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Conditions

Explore the condition pages connected to this study.

NON-MUSCLE INVASIVE BLADDER UROTHELIAL CARCINOMA RECURRENT NON-MUSCLE INVASIVE BLADDER UROTHELIAL CARCINOMA STAGE I BLADDER CANCER AJCC V8