New drug combo challenges standard chemo in major bladder cancer trial
NCT ID NCT04700124
Summary
This large, completed Phase 3 trial tested if a new combination of two immunotherapy/targeted drugs (enfortumab vedotin plus pembrolizumab) given before and after surgery works better than the current standard chemotherapy (gemcitabine plus cisplatin) for people with muscle-invasive bladder cancer who are eligible for cisplatin. The main goal was to see if the new combination helps patients live longer without their cancer returning or progressing. The study involved 808 participants and directly compared the two treatment strategies.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AOU San Luigi Gonzaga di Orbassano ( Site 0595)
Orbassano, Torino, 10043, Italy
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ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 0301)
Chaïdári, Attica, 124 62, Greece
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Altay Regional Oncology Dispensary ( Site 0851)
Barnaul, Altayskiy Kray, 656045, Russia
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Asan Medical Center ( Site 1352)
Songpagu, Seoul, 05505, South Korea
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Asociación de Beneficencia Hospital Sirio Libanés ( Site 1553)
Buenos Aires, Buenos Aires F.D., C1419AHN, Argentina
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Athens Medical Center ( Site 0304)
Athens, Attica, 151 25, Greece
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Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 0598)
Verona, Veneto, 37126, Italy
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Azienda Ospedaliero Universitaria delle Marche-Clinica Oncologica ( Site 0593)
Ancona, 60126, Italy
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BC Cancer - Vancouver Center ( Site 0110)
Vancouver, British Columbia, V5Z 4E6, Canada
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C.H. regional Unv. de Brest - Hopital La Cavale Blanche - Institut de Cancerologie et d Imagerie ( Site 0461)
Brest, Finistere, 29200, France
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CHU GRENOBLE ALPES ( Site 0468)
La Tronche, Isere, 38700, France
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CHU Jean Minjoz ( Site 0453)
Besançon, Doubs, 25000, France
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CHU La Timone ( Site 0456)
Marseille, Bouches-du-Rhone, 13005, France
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CHU Limoges Hopital Dupuytren ( Site 0459)
Limoges, Haute-Vienne, 87042, France
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CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0660)
Santiago de Compostela, La Coruna, 15706, Spain
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CancerCare Manitoba ( Site 0108)
Winnipeg, Manitoba, R3E 0V9, Canada
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Cardiomed SRL Cluj-Napoca ( Site 1101)
Cluj-Napoca, Cluj, 400015, Romania
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Caritas Krankenhaus St. Josef ( Site 0502)
Regensburg, Bavaria, 93053, Germany
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Centre Hospitalier Regional du Orleans ( Site 0463)
Orléans, Loiret, 45067, France
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Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 1558)
Buenos Aires, Buenos Aires F.D., C1431FWO, Argentina
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Centro de Urología (CDU) ( Site 1552)
Buenos Aires, 1120, Argentina
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Chang Gung Memorial Hospital at Kaohsiung ( Site 1203)
Kaohsiung City, 83301, Taiwan
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Charing Cross Hospital-Oncology Research ( Site 1802)
London, Hammersmith and Fulham, W6 8RF, United Kingdom
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China Medical University Hospital ( Site 1202)
Taichung, 404332, Taiwan
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Chonnam National University Hwasun Hospital ( Site 1353)
Jeollanam-do, Jeonranamdo, 58128, South Korea
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Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 1654)
Bogotá, Bogota D.C., 111321, Colombia
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Clinical Research Center Medic-R ( Site 1061)
Poznan, Greater Poland Voivodeship, 61-731, Poland
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Complex Oncology Center Plovdiv ( Site 1151)
Plovdiv, 4000, Bulgaria
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Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, 4032, Hungary
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Duke University Medical Center ( Site 0017)
Durham, North Carolina, 27710, United States
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Fakultni Nemocnice Olomouc ( Site 0251)
Olomouc, 77900, Czechia
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Fakultni Thomayerova nemocnice ( Site 0252)
Prague, 140 59, Czechia
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Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 0254)
Hradec Králové, 500 05, Czechia
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Fakultni nemocnice u sv. Anny v Brne ( Site 0253)
Brno, South Moravian, 656 91, Czechia
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First Moscow State Medical University n.a. I.M.Sechenov ( Site 0871)
Moscow, Moscow, 119991, Russia
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Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0588)
Milan, Lombardy, 20133, Italy
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Frankston Hospital-Oncology and Haematology ( Site 1258)
Frankston, Victoria, 3199, Australia
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Fudan University Shanghai Cancer Center-Urology department ( Site 1401)
Shanghai, Shanghai Municipality, 200032, China
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Fundacion Colombiana de Cancerología Clinica Vida ( Site 1653)
Medellín, Antioquia, 050030, Colombia
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Fundacion Estudios Clinicos-Oncology ( Site 1557)
Rosario, Santa Fe Province, S2000DEJ, Argentina
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Fundación Cardiovascular de Colombia-Santander ( Site 1657)
Piedecuesta, Santander Department, 681017, Colombia
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Fundación Instituto Valenciano de Oncología-Oncologico ( Site 0662)
Valencia, Valenciana, Comunitat, 46009, Spain
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Fundación Valle del Lili ( Site 1656)
Cali, Valle del Cauca Department, 760032, Colombia
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Gachon University Gil Medical Center ( Site 1356)
Incheon, 21565, South Korea
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General Hospital of Athens "Alexandra" ( Site 0303)
Athens, Attica, 115 28, Greece
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Gifu University Hospital ( Site 1513)
Gifu, 501-1194, Japan
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Groote Schuur Hospital ( Site 0602)
Cape Town, Western Cape, 7925, South Africa
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Gustave Roussy ( Site 0467)
Villejuif, Île-de-France Region, 94805, France
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Hadassah Medical Center-Oncology ( Site 0757)
Jerusalem, 9112001, Israel
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Hamamatsu University Hospital ( Site 1511)
Hamamatsu, Shizuoka, 431-3192, Japan
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Hirosaki University Hospital ( Site 1501)
Hirosaki, Aomori, 036-8563, Japan
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Hopital Diaconesses Croix Saint Simon ( Site 0465)
Paris, 75960, France
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Hospital Británico de Buenos Aires-Oncology ( Site 1551)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
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Hospital Clinico Universitario San Carlos de Madrid ( Site 0651)
Madrid, 28040, Spain
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Hospital Germans Trias i Pujol. ICO de Badalona ( Site 0658)
Badalona, Barcelona, 08916, Spain
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Hospital Italiano de Buenos Aires ( Site 1554)
ABB, Buenos Aires F.D., C1199ABB, Argentina
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Hospital Pulau Pinang ( Site 0355)
George Town, Pulau Pinang, 10450, Malaysia
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Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0661)
Barcelona, 08035, Spain
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Hospital Universitario Central de Asturias ( Site 0654)
Oviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario Insular de Gran Canaria ( Site 0657)
Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
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Hospital Virgen del Rocio ( Site 0659)
Seville, 41013, Spain
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Houston Methodist Urology Associates ( Site 0033)
Houston, Texas, 77030, United States
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Hunan Cancer Hospital ( Site 1403)
Changsha, Hunan, 410013, China
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I.I. Mechnykov Dnipropetrovsk Regional Clinical Hospital ( Site 0959)
Dnipro, Dnipropetrovsk Oblast, 49005, Ukraine
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IMAT S.A.S ( Site 1652)
Montería, Departamento de Córdoba, 230002, Colombia
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IRCCS Ospedale San Raffaele ( Site 0596)
Milan, 20132, Italy
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Icahn School of Medicine at Mount Sinai ( Site 0011)
New York, New York, 10029, United States
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Indiana University Melvin and Bren Simon Cancer Center ( Site 0050)
Indianapolis, Indiana, 46202, United States
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Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0409)
Lisbon, 1099-023, Portugal
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Institut Català d'Oncologia (ICO) - Girona ( Site 0653)
Girona, Gerona, 17007, Spain
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Institut Universitaire du Cancer Toulouse - Oncopole ( Site 0455)
Toulouse, Haute-Garonne, 31059, France
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Institute of Science Tokyo Hospital ( Site 1505)
Tokyo, 113-8519, Japan
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Institutul Oncologic Cluj-Oncologie Medicala ( Site 1109)
Cluj-Napoca, 400015, Romania
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Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1102)
Cluj-Napoca, Cluj, 400015, Romania
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Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1103)
Cluj-Napoca, Cluj, 400015, Romania
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Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 0600)
Padua, 35128, Italy
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Jewish General Hospital ( Site 0106)
Montreal, Quebec, H3T 1E2, Canada
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Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1002)
Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary
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Kanagawa Cancer Center ( Site 1507)
Yokohama, Kanagawa, 241-8515, Japan
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Kanazawa University Hospital ( Site 1509)
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kath. Krankenhaus Marienhospital. Universitaetsklinik ( Site 0511)
Herne, North Rhine-Westphalia, 44625, Germany
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Keio University Hospital ( Site 1504)
Tokyo, 160-8582, Japan
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Kitasato University Hospital ( Site 1506)
Sagamihara, Kanagawa, 252-0375, Japan
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Klinički Bolnički Centar Split-Oncology and Radiotherapy ( Site 1702)
Split, Split-Dalmatia County, 21000, Croatia
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Klinički bolnički centar Osijek ( Site 1705)
Osijek, County of Osijek-Baranja, 31000, Croatia
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Klinički bolnički centar Sestre milosrdnice ( Site 1703)
Zagreb, City of Zagreb, 10000, Croatia
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Klinički bolnički centar Zagreb-Klinika za onkologiju ( Site 1701)
Zagreb, City of Zagreb, 10000, Croatia
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Korea University Anam Hospital ( Site 1357)
Seoul, 02841, South Korea
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Krankenhaus Martha Maria Halle-Doelau ( Site 0507)
Halle, Saxony-Anhalt, 06120, Germany
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Kyungpook National University Chilgok Hospital ( Site 1354)
Daegu, Kyongsangbuk-do, 41404, South Korea
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Lviv Oncology Regional Treatment and Diagnostic Center ( Site 0960)
Lviv, Lviv Oblast, 79031, Ukraine
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Lyell McEwin Hospital ( Site 1252)
Elizabeth Vale, South Australia, 5112, Australia
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MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 1104)
Bucharest, București, 013823, Romania
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MHAT "Uni Hospital" OOD ( Site 1154)
Panagyurishte, Pazardzhik, 4500, Bulgaria
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MHAT Central Onco Hospital OOD ( Site 1158)
Plovdiv, 4000, Bulgaria
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MHAT Serdika ( Site 1152)
Sofia, 1632, Bulgaria
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MI Clinical oncology dispensary of Dnipropetrovsk regional council ( Site 0954)
Dnipro, Dnipropetrovsk Oblast, 49055, Ukraine
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MNPE Regional Center of Oncology ( Site 0955)
Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine
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Macquarie University-MQ Health Clinical Trials Unit ( Site 1259)
Macquarie University, New South Wales, 2109, Australia
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Mater Hospital Brisbane ( Site 1257)
South Brisbane, Queensland, 4101, Australia
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Mayo Clinic in Arizona - Phoenix ( Site 0043)
Phoenix, Arizona, 85054, United States
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Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1057)
Siedlce, Masovian Voivodeship, 08-110, Poland
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Meir Medical Center-oncology ( Site 0754)
Kfar Saba, 4428164, Israel
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MidLantic Urology ( Site 0002)
Bala-Cynwyd, Pennsylvania, 19004, United States
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Moncton Hospital ( Site 0107)
Moncton, New Brunswick, E1C 6Z8, Canada
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Municipal Non-profit Enterprise of Kharkiv Regional Council RCSDRPP ( Site 0965)
Kharkiv, Kharkivs’ka Oblast’, 61166, Ukraine
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Nagasaki University Hospital ( Site 1517)
Nagasaki, 852-8510, Japan
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Nagoya University Hospital ( Site 1512)
Nagoya, Aichi-ken, 466-8560, Japan
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 1404)
Nanjing, Jiangsu, 210008, China
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Nantong Tumor Hospital-Urology ( Site 1405)
Nantong, Jiangsu, 226361, China
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Narodowy Instytut Onkologii ( Site 1051)
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Medical Research Centre of Oncology named after N.N. Blokhin ( Site 0865)
Moscow, Moscow, 115230, Russia
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National Medical Research Radiology Centre ( Site 0869)
Obninsk, Kaluzskaja Oblast, 249036, Russia
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Okayama University Hospital ( Site 1516)
Okayama, 700-8558, Japan
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Oregon Health and Science University ( Site 0028)
Portland, Oregon, 97239-3011, United States
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Osaka International Cancer Institute ( Site 1514)
Osaka, 541-8567, Japan
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Osaka Metropolitan University Hospital ( Site 1515)
Osaka, 545-8586, Japan
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Ospedale Cannizzaro ( Site 0590)
Catania, 95126, Italy
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Ottawa Hospital Research Institute ( Site 0109)
Ottawa, Ontario, K1H 8L6, Canada
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Policlinica Oncomed SRL ( Site 1106)
Timișoara, Timiș County, 300239, Romania
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Polyclinique du Bois ( Site 0458)
Lille, Nord, 59000, France
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Presidio Ospedaliero Santa Maria delle Grazie ( Site 0599)
Pozzuoli, Napoli, 80078, Italy
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Rabin Medical Center-Oncology ( Site 0752)
Petah Tikva, 4941492, Israel
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Rambam Health Care Campus-Oncology ( Site 0751)
Haifa, 3109601, Israel
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Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval ( Site 0952)
Kharkiv, Kharkivs’ka Oblast’, 61037, Ukraine
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Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1402)
Shanghai, Shanghai Municipality, 200127, China
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S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1107)
Craiova, Dolj, 200542, Romania
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SC Radiotherapy Center Cluj SRL ( Site 1108)
Comuna Floresti, Cluj, 407280, Romania
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SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 1406)
Guangzhou, Guangdong, 510060, China
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Saint Francis Cancer Center ( Site 0008)
Greenville, South Carolina, 29607, United States
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Sarawak General Hospital ( Site 0351)
Kuching, Sarawak, 93586, Malaysia
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Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0852)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
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Seoul National University Bundang Hospital ( Site 1355)
Gyeonggi-do, Kyonggi-do, 13620, South Korea
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Seoul National University Hospital ( Site 1351)
Seoul, 03080, South Korea
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Sheba Medical Center-ONCOLOGY ( Site 0753)
Ramat Gan, 5265601, Israel
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Sourasky Medical Center-Oncology ( Site 0755)
Tel Aviv, 6423906, Israel
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St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1801)
London, London, City of, EC1A 7BE, United Kingdom
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St Joseph Heritage Healthcare-Oncology ( Site 0035)
Fullerton, California, 92835, United States
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St.Petersburg Clinical Hospital RAS ( Site 0864)
Saint Petersburg, Sankt-Peterburg, 194017, Russia
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St.Petersburg State Medical Univ. n.a. acad. I.P.Pavlov ( Site 0856)
Saint Petersburg, Sankt-Peterburg, 197101, Russia
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Stanford University ( Site 0023)
Stanford, California, 94305, United States
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Steve Biko Academic Hospital ( Site 0601)
Pretoria, Gauteng, 0002, South Africa
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1413)
Guangzhou, Guangdong, 510220, China
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Sunway Medical Centre ( Site 0353)
Petaling Jaya, Selangor, 47500, Malaysia
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Sverdlovsk Regional Oncology Hospital ( Site 0867)
Yekaterinburg, Sverdlovsk Oblast, 620036, Russia
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Sverdlovsky Regional Clinical hospital #1 ( Site 0868)
Yekaterinburg, Sverdlovsk Oblast, 620102, Russia
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Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 1010)
Szeged, Csongrád megye, 6720, Hungary
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Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1055)
Koszalin, West Pomeranian Voivodeship, 75-581, Poland
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THE MEDICAL CITY ILOILO-The Medical City Iloilo - Clinical and Translational Research Institute-Ilo ( Site 0801)
Iloilo City, Iloilo, 5000, Philippines
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Taipei Veterans General Hospital ( Site 1201)
Taipei, 112, Taiwan
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Tan Tock Seng Hospital ( Site 0704)
Singapore, Central Singapore, 308442, Singapore
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The University of Tennessee Medical Center ( Site 0034)
Knoxville, Tennessee, 37920, United States
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Tohoku University Hospital ( Site 1503)
Sendai, Miyagi, 980-8574, Japan
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Torbay Hospital ( Site 1804)
Torquay, Devon, TQ2 7AA, United Kingdom
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Toyama University Hospital ( Site 1510)
Toyama, 930-0194, Japan
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UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 0005)
Los Angeles, California, 90095, United States
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UF Health ( Site 0031)
Gainesville, Florida, 32608, United States
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UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0305)
Pátrai, Achaia, 26504, Greece
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UT Southwestern Medical Center ( Site 0003)
Dallas, Texas, 75390, United States
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Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 0401)
Lisbon, 1449-005, Portugal
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Unidade Local de Saude de Coimbra - Hospitais da Universidade de Coimbra ( Site 0406)
Coimbra, 3000-075, Portugal
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Unidade Local de Saude de Santo António - Hospital Santo António ( Site 0408)
Porto, 4099-001, Portugal
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Universitaetsklinik fuer Urologie ( Site 0501)
Tübingen, Baden-Wurttemberg, 72076, Germany
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Universitaetsklinikum Carl Gustav Carus ( Site 0509)
Dresden, Saxony, 01307, Germany
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Universitaetsklinikum Freiburg ( Site 0512)
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Universitaetsklinikum Muenster ( Site 0516)
Münster, North Rhine-Westphalia, 48149, Germany
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Universitaetsklinikum Wuerzburg ( Site 0520)
Würzburg, Bavaria, 97080, Germany
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University General Hospital of Larissa ( Site 0302)
Larissa, Thessaly, 411 10, Greece
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University Malaya Medical Centre ( Site 0352)
Lembah Pantai, Kuala Lumpur, 59100, Malaysia
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University of California San Francisco ( Site 0010)
San Francisco, California, 94158, United States
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University of Colorado, Anschutz Cancer Pavilion ( Site 0009)
Aurora, Colorado, 80045, United States
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University of Iowa Hospital and Clinics ( Site 0029)
Iowa City, Iowa, 52242, United States
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University of Louisville, James Graham Brown Cancer Center ( Site 0022)
Louisville, Kentucky, 40202, United States
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University of Tsukuba Hospital ( Site 1502)
Tsukuba, Ibaraki, 305-8576, Japan
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University of Wisconsin Hospital and Clinics ( Site 0037)
Madison, Wisconsin, 53792, United States
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Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 1058)
Wrocław, Silesian Voivodeship, 50556, Poland
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Urology of San Antonio ( Site 0020)
San Antonio, Texas, 78229, United States
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Vivantes Klinikum Am Urban ( Site 0519)
Berlin, 10967, Germany
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Volga District Medical Center ( Site 0876)
Nizhny Novgorod, Nizhny Novgorod Oblast, 603074, Russia
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Volgograd Regional Uronephrological Center ( Site 0870)
Volzhsky, Volgograd Oblast, 404120, Russia
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Wake Forest Baptist Health ( Site 0014)
Winston-Salem, North Carolina, 27157, United States
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White Plains Hospital ( Site 0039)
White Plains, New York, 10601, United States
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Wits Clinical Research ( Site 0603)
Johannesburg, Gauteng, 2193, South Africa
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Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1053)
Przemyśl, Podkarpackie Voivodeship, 37-700, Poland
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Xarxa Assistencial Universitaria Manresa ( Site 0655)
Manresa, Barcelona, 08243, Spain
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Yitzhak Shamir Medical Center-Oncology ( Site 0756)
Ẕerifin, 70300, Israel
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Yokohama City University Medical Center ( Site 1508)
Yokohama, Kanagawa, 232-0024, Japan
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Zhytomyr Regional Oncology Center ( Site 0961)
Zhytomyr, Zhytomyr Oblast, 10002, Ukraine
Conditions
Explore the condition pages connected to this study.