New drug aims to shrink Hard-to-Treat lung cancers

NCT ID NCT05882058

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This phase 2 trial tests BI 764532 (obrixtamig), an antibody-like drug designed to help the immune system attack cancer cells. It is for adults with advanced small cell lung cancer or other neuroendocrine cancers that have not responded to prior treatments. The study compares two doses to find one that is tolerable and effective, with the goal of shrinking tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 764532 (obrixtamig), an antibody-like molecule that helps the immune system fight cancer
What this could lead to: If it works, this could point toward a new treatment option for people with advanced small cell lung cancer or other neuroendocrine cancers that have stopped responding to standard therapy.
What could go wrong: This is a mid-stage trial with only 204 participants, so results may not apply to everyone. The drug may cause side effects or fail to shrink tumors in many patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuroendocrine carcinoma neuroendocrine neoplasm pulmonary large cell neuroendocrine carcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRA-PULMONARY NEUROENDOCRINE CARCINOMA NEUROENDOCRINE NEOPLASMS SMALL CELL LUNG CARCINOMA

Contacts and locations

Locations

960 Hospital of the Chinese People's Liberation Army
RECRUITING

Jinan, 250031, China
Aichi Cancer Center Hospital
RECRUITING

Aichi, Nagoya, 464-8681, Japan
Asan Medical Center
COMPLETED

Seoul, 05505, South Korea
Asklepios Fachkliniken München-Gauting
COMPLETED

Gauting, 82131, Germany
Chang Gung Memorial Hospital, Linkou
COMPLETED

Taoyuan County, 333, Taiwan
Dana-Farber Cancer Institute
COMPLETED

Boston, Massachusetts, 02215, United States
Evangelische Lungenklinik Berlin
COMPLETED

Berlin, 13125, Germany
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
H. Lee Moffitt Cancer Center and Research Institute
RECRUITING

Tampa, Florida, 33612, United States
HOP Civil
COMPLETED

Strasbourg, 67091, France
HOP Intercommunal
COMPLETED

Créteil, 94000, France
Hospital CUF Descobertas-Lisboa-69316
COMPLETED

Lisbon, 1350-352, Portugal
Hospital CUF Porto
COMPLETED

Porto, 4100-180, Portugal
Hospital Clinico Universitario de Valencia
COMPLETED

Valencia, 46010, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital del Mar
COMPLETED

Barcelona, 08003, Spain
Hôpital Cochin
COMPLETED

Paris, 75014, France
Indiana University
COMPLETED

Indianapolis, Indiana, 46202, United States
Infirmary Cancer Care
RECRUITING

Mobile, Alabama, 36607, United States
Japanese Foundation for Cancer Research
RECRUITING

Tokyo, Koto-ku, 135-8550, Japan
Kindai University Hospital
RECRUITING

Osaka, Sakai, 590-0197, Japan
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
COMPLETED

New York, New York, 10016, United States
Leicester Royal Infirmary
RECRUITING

Leicester, LE1 5WW, United Kingdom
LungenClinic Grosshansdorf GmbH
ACTIVE_NOT_RECRUITING

Großhansdorf, 22927, Germany
MHAT Heart and brain
COMPLETED

Pleven, 5804, Bulgaria
Mayo Clinic Cancer Center
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic, Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic-Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Multiprofile Hospital For Active Treatment-Uni Hospital Ltd.
COMPLETED

Panagyurishte, 4500, Bulgaria
NCKUH
COMPLETED

Tainan, 704, Taiwan
National Cancer Center Hospital
RECRUITING

Tokyo, Chuo-ku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Chiba, Kashiwa, 277-8577, Japan
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, 541-8567, Japan
Qilu Hospital, Shangdong University
RECRUITING

Jinan, 250012, China
Samsung Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 06351, South Korea
Sendai Kousei Hospital
COMPLETED

Miyagi, Sendai, 981-0914, Japan
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
Shanghai Chest Hospital
RECRUITING

Shanghai, 200030, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
RECRUITING

Hangzhou, 310016, China
Taipei Veterans General Hospital
COMPLETED

Taipei, 11217, Taiwan
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The Second Affiliated Hospital to Nanchang University
RECRUITING

Nanchang, 330006, China
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
University College Hospital
RECRUITING

London, WC1E 6AG, United Kingdom
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Kansas Cancer Center
COMPLETED

Westwood, Kansas, 66205, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
RECRUITING

Mainz, 55131, Germany
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Virginia Commonwealth University Health- Adult Outpatient Pavilion
RECRUITING

Richmond, Virginia, 23219, United States
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China

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