New pill could help when depression meds fail

NCT ID NCT06280235

First seen Apr 11, 2026 · Last updated May 14, 2026 · Updated 3 times

Summary

This study tested an experimental medicine called BI 1569912 in 243 adults with major depression whose previous treatments didn't work. Participants took either a placebo or one of three doses of the medicine daily for 6 weeks, while continuing their usual therapy. The goal was to see if the new medicine could further reduce depression symptoms.

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Contacts and locations

Locations

  • A-SHINE s.r.o

    Pilsen, 30100, Czechia

  • ActivMed Practices & Research

    Methuen, Massachusetts, 01844, United States

  • Adams Clinical

    Watertown, Massachusetts, 02472, United States

  • Aisakura Clinic

    Fukuoka, 810-0001, Japan

  • Ambulatory for Individual Practice for Specialized Medical Care in Psychiatry - Dr Ivo Natsov

    Cherven Bryag, 5980, Bulgaria

  • Anima Research Center

    Alken, 3570, Belgium

  • Asclepes Research Centers-Panorama City-62905

    Panorama City, California, 91402, United States

  • Beijing Anding Hospital

    Beijing, 100088, China

  • Boston Clinical Trials

    Roslindale, Massachusetts, 02135, United States

  • CCM Clinical Research Group, LLC-Miami-68482

    Miami, Florida, 33133, United States

  • CT Clinical Research

    Cromwell, Connecticut, 06416, United States

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Chicago Research Center, Incorporated

    Chicago, Illinois, 60634, United States

  • Clintrial s.r.o.

    Prague, 100 00, Czechia

  • DCC "Sv. Vrach and Sv. Sv. Kuzma and Damyan" OOD

    Sofia, 1408, Bulgaria

  • DCC Mladost-M Varna OOD

    Varna, 9020, Bulgaria

  • Excell Research Inc.

    Oceanside, California, 92056, United States

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180, Japan

  • Galiz Research

    Hialeah, Florida, 33016, United States

  • Grayline Research Center

    Wichita Falls, Texas, 76309, United States

  • Hassman Research Institute-Marlton-66897

    Marlton, New Jersey, 08053, United States

  • Hebei Mental Health Center

    Baoding, 71000, China

  • Hirota Clinic

    Kurume-shi, 830-0033, Japan

  • Houston Clinical Trials, LLC

    Bellaire, Texas, 77401, United States

  • Iwaki Clinic, Tokushima, Psychosomatic Medicine

    Anan-shi, 774-0014, Japan

  • Kaku Mental Clinic

    Fukuoka, 810-0022, Japan

  • Kuramitsu Hospital

    Fukuoka, 819-0037, Japan

  • Kyorin University Hospital

    Mitaka-shi, 181-8611, Japan

  • MHC - Ruse, EOOD

    Rousse, 7003, Bulgaria

  • Maynds Tower Mental Clinic

    Shibuya-ku, 151-0053, Japan

  • Medical Center "Sv.Naum"

    Sofia, 1113, Bulgaria

  • Medical Center Hera EOOD

    Sofia, 1510, Bulgaria

  • Medical Center Intermedica Ltd.

    Sofia, 1680, Bulgaria

  • Mental Clinic Sakurazaka

    Fukuoka, 810-0023, Japan

  • Midwest Clinical Research

    Dayton, Ohio, 45417, United States

  • NRC Research Institute

    Orange, California, 92868, United States

  • Neuro-Behavioral Clinical Research

    North Canton, Ohio, 44720, United States

  • Neurobehavioral Research, Inc.

    Cedarhurst, New York, 11516, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Peking University Sixth Hospital

    Beijing, 100191, China

  • Premier Clinical Research Institute

    Miami, Florida, 33122, United States

  • Rainbow and Sea Hospital

    Karatsu-shi, 847-0031, Japan

  • Shanghai Mental Health Center

    Shanghai, 200030, China

  • Shenzhen Kangning Hospital

    Shenzhen, 518003, China

  • Somni Bene - Institut für Medizinische Forschung & Schlafmedizin Schwerin GmbH

    Schwerin, 19053, Germany

  • Sooner Clinical Research

    Oklahoma City, Oklahoma, 73112, United States

  • Southwest Biomedical Research, LLC

    Tucson, Arizona, 85712, United States

  • The First Hospital of Hebei Medical University

    Shijiazhuang, 50030, China

  • The Second Xiangya Hospital Of Central South University

    Changsha, 410011, China

  • Tianjin Anding Hospital

    Tianjin, 300222, China

  • Universitair Psychiatrisch Centrum Duffel (UPC Duffel)

    Duffel, 2570, Belgium

  • iResearch Atlanta

    Decatur, Georgia, 30030, United States

Conditions

Explore the condition pages connected to this study.