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New hope for advanced breast cancer: phase 3 trial compares experimental combo to standard care

NCT ID NCT07492641

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called BGB-43395 combined with letrozole against standard CDK4/6 inhibitor drugs (abemaciclib, palbociclib, or ribociclib) plus letrozole for people with advanced or metastatic HR+/HER2- breast cancer who have not had prior treatment for advanced disease. About 1056 participants will be enrolled to see if the new combination improves progression-free survival and overall survival. The study is currently recruiting.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HR+/HER2- BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alaska Oncology and Hematology, Llc

    RECRUITING

    Anchorage, Alaska, 99508-2974, United States

  • Asan Medical Center

    RECRUITING

    SongpaGu, Seoul Teugbyeolsi, 05505, South Korea

  • Astera Cancer Care East Brunswick

    RECRUITING

    East Brunswick, New Jersey, 08816-4096, United States

  • Blacktown Cancer and Haematology Centre

    RECRUITING

    Blacktown, New South Wales, NSW 2148, Australia

  • Brcr Coral Springs

    RECRUITING

    Coral Springs, Florida, 33065, United States

  • Cancer Care Specialists For Illinois

    RECRUITING

    O'Fallon, Illinois, 62269, United States

  • Cancer Institute Hospital of Jfcr

    RECRUITING

    Kotoku, Tokyo, 135-8550, Japan

  • Chonnam National University Hwasun Hospital

    RECRUITING

    HwasunGun, Jeollanam-do, 58128, South Korea

  • Ehwa Womans University Mokdong Hospital

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 07985, South Korea

  • Florida Clinical Trials Group Tamarac

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Fort Wayne Medical Oncology and Hematology

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • Gabrail Cancer Center Research

    RECRUITING

    Canton, Ohio, 44718-2566, United States

  • Gangnam Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 06273, South Korea

  • Hospital Wanita Dan Kanak Kanak Sabah (Hospital Likas)

    RECRUITING

    Kota Kinabalu Sabah, 88996, Malaysia

  • Inha University Hospital

    RECRUITING

    Junggu, Incheon Gwang'yeogsi, 22332, South Korea

  • Inje University Haeundae Paik Hospital

    RECRUITING

    HaeundaeGu, Busan Gwang'yeogsi, 48108, South Korea

  • Ironwood Cancer and Research Centers Chandler Ii

    RECRUITING

    Chandler, Arizona, 85224-5665, United States

  • Keimyung University Dongsan Hospital

    RECRUITING

    Dalseogu, Daegu Gwang'yeogsi, 42601, South Korea

  • Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68130-2042, United States

  • Northwest Medical Specialties

    RECRUITING

    Tacoma, Washington, 98405, United States

  • One Clinical Research

    RECRUITING

    Nedlands, Western Australia, WA 6009, Australia

  • Pardee Cancer Center

    RECRUITING

    Hendersonville, North Carolina, 28739, United States

  • Peter Maccallum Cancer Centre

    RECRUITING

    Melbourne, Victoria, VIC 3000, Australia

  • Sarawak General Hospital

    RECRUITING

    Kuching, 93586, Malaysia

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    RECRUITING

    SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea

  • Sunshine Coast University Private Hospital

    RECRUITING

    Birtinya, Queensland, QLD 4575, Australia

  • Tokyo Womens Medical University Hospital

    RECRUITING

    Shinjukuku, Tokyo, 162-8666, Japan

  • Wollongong Hospital

    RECRUITING

    Wollongong, New South Wales, NSW 2500, Australia