New Triple-Action antibody takes on Hard-to-Treat cancers

NCT ID NCT06598800

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This early-phase study tests a new drug called BG-T187, a special antibody that targets two proteins (EGFR and MET) on cancer cells. It is given alone or with other drugs to people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 153 participants will take part in this first-in-human trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BG-T187 (a trispecific antibody targeting EGFR and MET proteins)
What this could lead to: If successful, this could lead to a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong: This is an early phase 1 trial with only 153 participants, so the drug may not be safe or effective. Side effects could be serious, and the drug may not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Affiliated Zhongshan Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Asan Medical Center
RECRUITING

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Blacktown Cancer and Haematology Centre
RECRUITING

Blacktown, New South Wales, NSW 2148, Australia
Cabrini Hospital Malvern
RECRUITING

Malvern, Victoria, VIC 3144, Australia
Cancer Hospital Chinese Academy of Medical Sciences
RECRUITING

Beijing, Beijing Municipality, 100021, China
Chongqing University Cancer Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Fujian Medical University Union Hospitalqishan Branch
RECRUITING

Fuzhou, Fujian, 350108, China
Guangxi Medical University Cancer Hospital
RECRUITING

Nanning, Guangxi, 530021, China
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601-1915, United States
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150000, China
Hubei Cancer Hospital
RECRUITING

Wuhan, Hubei, 430079, China
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, WA 6009, Australia
Linyi Peoples Hospital
RECRUITING

Linyi, Shandong, 276000, China
Macquarie University
RECRUITING

North Ryde, New South Wales, NSW 2109, Australia
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Samsung Medical Center
RECRUITING

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Shanxi Provincial Cancer Hospital
RECRUITING

Taiyuan, Shanxi, 030013, China
The Catholic University of Korea, Seoul St Marys Hospital
RECRUITING

SeochoGu, Seoul Teugbyeolsi, 06591, South Korea
The Catholic University of Korea, St Vincents Hospital
RECRUITING

PaldalGu SuwonSi, Gyeonggi-do, 16247, South Korea
The First Affiliated Hospital, Zhejiang University School of Medicinezhijiang Branch
RECRUITING

Hangzhou, Zhejiang, 310024, China
The Sixth Affiliated Hospital, Sun Yat Sen University
RECRUITING

Guangzhou, Guangdong, 510655, China
The University of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4009, United States
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430030, China
Washington University, St Louis, Division of Oncology
RECRUITING

Madison, Wisconsin, 53708-8056, United States
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, 310022, China

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