New drug combo aims to shrink Hard-to-Treat tumors
NCT ID NCT05327010
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 39 times
Summary
This study tests whether two drugs, ZEN-3694 and talazoparib, can shrink tumors in people with advanced solid cancers that have spread or cannot be removed. About 88 adults will take part. The study also looks at how a person's genes might affect whether the treatment works. The goal is to slow or stop tumor growth.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope at Irvine Lennar
RECRUITINGIrvine, California, 92618, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-••••
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Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITINGSalt Lake City, Utah, 84112, United States
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Keck Medicine of USC Koreatown
ACTIVE_NOT_RECRUITINGLos Angeles, California, 90020, United States
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Los Angeles General Medical Center
ACTIVE_NOT_RECRUITINGLos Angeles, California, 90033, United States
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cancer Institute Developmental Therapeutics Clinic
RECRUITINGBethesda, Maryland, 20892, United States
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Contact Phone: •••-•••-••••
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National Institutes of Health Clinical Center
ACTIVE_NOT_RECRUITINGBethesda, Maryland, 20892, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ochsner Medical Center Jefferson
RECRUITINGNew Orleans, Louisiana, 70121, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Smilow Cancer Hospital Care Center-Trumbull
ACTIVE_NOT_RECRUITINGTrumbull, Connecticut, 06611, United States
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UC San Diego Medical Center - Hillcrest
RECRUITINGSan Diego, California, 92103, United States
Contact
Contact Email: •••••@•••••
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCHealth University of Colorado Hospital
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-••••
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UF Health Cancer Institute - Gainesville
ACTIVE_NOT_RECRUITINGGainesville, Florida, 32610, United States
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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USC / Norris Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGLos Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
ACTIVE_NOT_RECRUITINGNewport Beach, California, 92663, United States
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University of California Davis Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGSacramento, California, 95817, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Cancer Center - Lee's Summit
RECRUITINGLee's Summit, Missouri, 64064, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Cancer Center - North
RECRUITINGKansas City, Missouri, 64154, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Cancer Center at North Kansas City Hospital
SUSPENDEDNorth Kansas City, Missouri, 64116, United States
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University of Kansas Cancer Center-Overland Park
RECRUITINGOverland Park, Kansas, 66210, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Clinical Research Center
RECRUITINGFairway, Kansas, 66205, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Hospital-Indian Creek Campus
RECRUITINGOverland Park, Kansas, 66211, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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Contact Phone: •••-•••-••••
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Contact Phone: •••-•••-••••
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University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Medical Branch
RECRUITINGGalveston, Texas, 77555-0565, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas at Austin
ACTIVE_NOT_RECRUITINGAustin, Texas, 78712, United States
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yale University
ACTIVE_NOT_RECRUITINGNew Haven, Connecticut, 06520, United States
Conditions
Explore the condition pages connected to this study.