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Promising nasal polyp drug trial halted early – what it means

NCT ID NCT04157335

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 28 times

Summary

This study tested a drug called benralizumab in 295 adults with severe nasal polyps and chronic sinusitis. The goal was to see if it could shrink polyps and improve breathing and smell better than a placebo. The trial was stopped early, so the full results are not available, but the data may still help researchers understand how to treat this condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Huntington Beach, California, 92647, United States

  • Research Site

    Grand Junction, Colorado, 81501, United States

  • Research Site

    Gainesville, Florida, 32605, United States

  • Research Site

    Louisville, Kentucky, 40220, United States

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    White Marsh, Maryland, 21162, United States

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    The Bronx, New York, 10461, United States

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    White Plains, New York, 10605, United States

  • Research Site

    Tulsa, Oklahoma, 74136, United States

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    Bethlehem, Pennsylvania, 18017, United States

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    Fort Worth, Texas, 76109, United States

  • Research Site

    McKinney, Texas, 75070, United States

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    St. George, Utah, 84790, United States

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    Richmond, Virginia, 23235, United States

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    Bellingham, Washington, 98225, United States

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    Milwaukee, Wisconsin, 53228, United States

  • Research Site

    Buenos Aires, C1121 ABE, Argentina

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    Buenos Aires, C1414AIF, Argentina

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    Ciudad de Buenos Aire, C1425BEN, Argentina

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    San Fernando, B1646EBJ, Argentina

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    Herston, 4029, Australia

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    Melbourne, 3004, Australia

  • Research Site

    Spearwood, 6163, Australia

  • Research Site

    Brussels, 1200, Belgium

  • Research Site

    Ghent, 9000, Belgium

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    Leuven, 3000, Belgium

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    Plovdiv, 4001, Bulgaria

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    Sofia, 1303, Bulgaria

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    Sofia, 1606, Bulgaria

  • Research Site

    Quillota, 2260000, Chile

  • Research Site

    Santiago, 7500588, Chile

  • Research Site

    Santiago, 8150000, Chile

  • Research Site

    Talca, 3481349, Chile

  • Research Site

    Beijing, 100044, China

  • Research Site

    Beijing, 100191, China

  • Research Site

    Beijing, 100730, China

  • Research Site

    Changchun, 130061, China

  • Research Site

    Changsha, 410008, China

  • Research Site

    Changsha, 410013, China

  • Research Site

    Changsha, China

  • Research Site

    Chengdu, 610041, China

  • Research Site

    Chengdu, 610072, China

  • Research Site

    Chongqing, 400042, China

  • Research Site

    Foshan, 528000, China

  • Research Site

    Guangzhou, 510000, China

  • Research Site

    Guangzhou, 510180, China

  • Research Site

    Hangzhou, 310003, China

  • Research Site

    Jinan, 250014, China

  • Research Site

    Nanchang, 330006, China

  • Research Site

    Nanjing, 210029, China

  • Research Site

    Nanning, 530021, China

  • Research Site

    Qingdao, 266071, China

  • Research Site

    Shanghai, 200065, China

  • Research Site

    Shanghai, 200092, China

  • Research Site

    Tianjin, 300050, China

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    Ürümqi, 830054, China

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    Wuhan, 430022, China

  • Research Site

    Xi'an, 710004, China

  • Research Site

    Xi'an, 710061, China

  • Research Site

    Yantai, 264000, China

  • Research Site

    Marseille, 13005, France

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    Toulouse, 31059, France

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    Budapest, 1033, Hungary

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    Budapest, 1046, Hungary

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    Győr, 9024, Hungary

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    Kaposvár, 7400, Hungary

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    Siófok, 8600, Hungary

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    Székesfehérvár, 8000, Hungary

  • Research Site

    Tatabánya, 2800, Hungary

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    Catanzaro, 88100, Italy

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    Pisa, 56124, Italy

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    Roma, 00161, Italy

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    Roma, 00168, Italy

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    Chiba, 262-0015, Japan

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    Fujisawa-shi, 251-0052, Japan

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    Hiroshima, 734-8551, Japan

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    Ichikawa-shi, 272-0143, Japan

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    Iida-shi, 395-8505, Japan

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    Kawasaki-shi, 211-0063, Japan

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    Kumamoto, 860-0814, Japan

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    Meguro-ku, 153-0061, Japan

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    Meguro-ku, 153-8515, Japan

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    Minatoku, 105-8471, Japan

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    Moriguchi-shi, 570-0074, Japan

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    Nagaoka-shi, 940-2085, Japan

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    Osaka, 540-0008, Japan

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    Shinjuku-ku, 160-0017, Japan

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    Yoshida-gun, 910-1193, Japan

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    Bydgoszcz, 85-231, Poland

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    Elblag, 82-300, Poland

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    Krakow, 31-513, Poland

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    Lublin, 20-552, Poland

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    Nadarzyn, 05-830, Poland

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    Poznan, 60-805, Poland

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    Wroclaw, 53-301, Poland

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    Łodź, 90-153, Poland

  • Research Site

    Izhevsk, 426061, Russia

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    Penza, 440067, Russia

  • Research Site

    Saint Petersburg, 196158, Russia

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    Taipei, 10002, Taiwan

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    Taipei, 110, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    Taipei, 114, Taiwan

  • Research Site

    Taipei, 235, Taiwan

  • Research Site

    Taoyuan, 333, Taiwan

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    Bangkok, 10330, Thailand

  • Research Site

    Bangkok, 10400, Thailand

  • Research Site

    Bangkok, 10700, Thailand

  • Research Site

    Chiang Mai, 50200, Thailand

  • Research Site

    Khon Kaen, 40002, Thailand

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    Phitsanulok, 65000, Thailand

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    Aydin, 09100, Turkey (Türkiye)

  • Research Site

    Bakırköy, 34147, Turkey (Türkiye)

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    Izmir, 35340, Turkey (Türkiye)

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    Malatya, 44280, Turkey (Türkiye)

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    Hanoi, 100000, Vietnam

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    Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

EOSINOPHILIC CHRONIC RHINOSINUSITIS NASAL POLYPOSIS