New triple therapy shows promise for stubborn high cholesterol

NCT ID NCT06686615

Recruiting now Disease control Sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study looks at how well a combination of three cholesterol-lowering medicines (bempedoic acid, ezetimibe, and a statin) works in real-world patients with high cholesterol or mixed lipid problems. About 2,000 adults at high or very high risk will be followed for up to a year. The goal is to see if the triple therapy safely lowers bad cholesterol more effectively than current options.

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Conditions

The condition(s) this trial relates to.

familial hypercholesterolemia hyperlipidemia, familial combined, LPL related

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIXED DYSLIPIDEMIA PRIMARY HYPERCHOLESTEROLEMIIA

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

A.Z. KLINA Brasschaat
RECRUITING

Brasschaat, 2930, Belgium
AKH Wien
RECRUITING

Vienna, 1090, Austria
AO Cardarelli
RECRUITING

Naples, 80131, Italy
AO Moscati
RECRUITING

Avellino, 83100, Italy
AOU Vanvitelli, I Policlinico
RECRUITING

Naples, 80138, Italy
AOUI Verona
RECRUITING

Verona, 37126, Italy
AZ Delta
RECRUITING

Roeselare, 8800, Belgium
AZ Glorieux
RECRUITING

Ronse, 9600, Belgium
AZ Groeninge Kortrijk
RECRUITING

Kortrijk, 8500, Belgium
Algemeen Ziekenhuis Sint-Jan Oostende
RECRUITING

Bruges, 8400, Belgium
Az Sint Lucas
RECRUITING

Ghent, 9000, Belgium
Azorg
RECRUITING

Aalst, 9300, Belgium
BBT Trier
TERMINATED

Trier, 54292, Germany
CHR Citadelle de Liège
ACTIVE_NOT_RECRUITING

Liège, 4000, Belgium
CHR Huy
ACTIVE_NOT_RECRUITING

Huy, 4500, Belgium
CHU Brugman
RECRUITING

Brussels, 1020, Belgium
CHU Charleroi Hopital civil Marie-Curie
RECRUITING

Charleroi, 6042, Belgium
CHU Mons Ambroise Paré
RECRUITING

Mons, 7000, Belgium
CHU UCL Mont-Godinne
RECRUITING

Yvoir, 5530, Belgium
Cardio Centrum Ludwigsburg
RECRUITING

Ludwigsburg, 71634, Germany
Cardiologicum Dresden
RECRUITING

Dresden, 01796, Germany
Cisanello
RECRUITING

Pisa, 56124, Italy
Clinic Hietzing
RECRUITING

Vienna, 1130, Austria
Clínica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Consorcio Hospital General Univ de Valencia
RECRUITING

Valencia, 46014, Spain
DOZ (Dialyse- und Ordinationszentrum) Privatklinik Wehrle-Diakonissen
RECRUITING

Salzburg, 5026, Austria
DRK Krankenhaus Lichtenstein Gemeinnützige GmbH
RECRUITING

Lichtenstein, 09350, Germany
Diabetologische Schwerpunktpraxis
RECRUITING

Trier, 54292, Germany
Dialysezentrum Hellersdorf Mitte
RECRUITING

Berlin, 12627, Germany
Dialysezentrum Hofaue
TERMINATED

Wuppertal, 42103, Germany
Ente Ecclesiastico "Miulli"
RECRUITING

Acquaviva delle Fonti, 70021, Italy
Epicure Hornu
RECRUITING

Boussu, 7301, Belgium
GHDC Charleroi - Site Hôpital Saint-Joseph
RECRUITING

Charleroi, 6060, Belgium
GK Mittelrhein
RECRUITING

Koblenz, 56073, Germany
H. Clínico Univ. De Valencia
RECRUITING

Valencia, 46010, Spain
H. Costa del Sol
RECRUITING

Marbella (Málaga), 29603, Spain
H. General de Elche
RECRUITING

Alicante, 03203, Spain
H. Juan Ramón Jiménez
RECRUITING

Huelva, 21005, Spain
H. Punta de Europa
RECRUITING

Cadiz, 11207, Spain
H. Univ. De Cabueñes
RECRUITING

Gijón, 33394, Spain
H. Univ. Puerta del Mar
RECRUITING

Cadiz, 11009, Spain
H. Univ. Reina Sofía
RECRUITING

Córdoba, 14004, Spain
H. Univers. De Albacete
RECRUITING

Albacete, 02006, Spain
H. Virgen de la Arrixaca
RECRUITING

Murcia, 30120, Spain
H. Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
H. Virgen de las Nieves
RECRUITING

Granada, 18014, Spain
HPK Heidelberger Praxisklinik
RECRUITING

Heidelberg, 69115, Germany
Hausärztlich-kardiologisches MVZ,,Am Felsenkeller" GmbH
RECRUITING

Pirna, 01796, Germany
Herz- und Gefäßmedizin Goslar
RECRUITING

Goslar, 38640, Germany
Herzklinik
RECRUITING

Ulm, 89077, Germany
Herzzentrum 18
RECRUITING

Vienna, 1180, Austria
Hospital Clinico Universitaro Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital General Universitario Dr. Balmis
RECRUITING

Alicante, 03010, Spain
Hospital General Universitario Reina Sofía
RECRUITING

Murcia, 30003, Spain
Hospital General Universitario de Toledo
ACTIVE_NOT_RECRUITING

Toledo, 45007, Spain
Hospital La Fe
RECRUITING

Valencia, 46026, Spain
Hospital San Pedro
RECRUITING

Logroño, 26006, Spain
Hospital Serranía de Ronda
RECRUITING

Málaga, 29400, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario Médico-Quirúrgico de Jaén
RECRUITING

Jaén, 23007, Spain
Hospital Universitario Puerto Real
RECRUITING

Cadiz, 11510, Spain
Hospital Universitario Son LLatzer
RECRUITING

Palma de Mallorca, 07198, Spain
Hospital Universitario de Burgos
RECRUITING

Burgos, 09006, Spain
Hospital Universitario de Canarias
RECRUITING

Santa Cruz de Tenerife, 38320, Spain
Hospital Universitario de Cruces
RECRUITING

Barakaldo, 48903, Spain
Hospital Universitario de Donostia
RECRUITING

Donostia / San Sebastian, 20014, Spain
Hospital Universitario de Gran Canarias Dr. Negrín
RECRUITING

Las Palmas de GC, 35010, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, 31008, Spain
Hospital Universitario de San Juan
RECRUITING

Alicante, 03550, Spain
Hospital Universitario de Álava
RECRUITING

Vitoria-Gasteiz, 01009, Spain
Hospital de León
RECRUITING

León, 24008, Spain
Hospital de Segovia
RECRUITING

Segovia, 40002, Spain
ICS Maugeri
RECRUITING

Pavi, 27100, Italy
INRCA
RECRUITING

Ancona, 60127, Italy
IRCCS Galeazzi Sant'Ambrogio
RECRUITING

Milan, 20157, Italy
IRCCS Monzino
RECRUITING

Milan, 20138, Italy
Innere Medizin
RECRUITING

Braunau am Inn, 5280, Austria
Innere Medizin
RECRUITING

Klagenfurt, 9020, Austria
Innere Medizin
RECRUITING

Linz, 4020, Austria
Innere Medizin 1
RECRUITING

Feldkirch, 6800, Austria
Innere Medizin 3 - Kardiologie
RECRUITING

Innsbruck, 6020, Austria
JAN YPERMAN Ziekenhuis
RECRUITING

Leper, 8900, Belgium
Jessa Ziekenhuis
RECRUITING

Hasselt, 3500, Germany
Kardiologie Gem. Praxis Dres Reiff/Linse/Haj-Yehia/Specking
RECRUITING

Moers, 47441, Germany
Kardiologie am Tibarg
RECRUITING

Hamburg, 22459, Germany
Kardiologie-Urfahr Dr. Hönig & Dr. Gammer & Dr. Buchmayr
RECRUITING

Linz, 4040, Austria
Kardiologische Gemeinschaftpraxis Papenburg
RECRUITING

Papenburg, 26871, Germany
Kardiologische Gemeinschaftspraxis Flemmingstr.
RECRUITING

Chemnitz, 09116, Germany
Kardiologische Gemeinschaftspraxis Papenburg
RECRUITING

Papenburg, 26871, Germany
Kardiologische Gemeinschaftspraxis am Park Sanssouci
RECRUITING

Potsdam, 14469, Germany
Kardiologische Praxis Markkleeberg
RECRUITING

Markkleeberg, 04416, Germany
Kardiopraxis
RECRUITING

Kaiserslautern, 67655, Germany
Kardiopraxis
RECRUITING

Mainz, 55122, Germany
Karl Landsteiner Institut für kardiovaskuläre und intensivmedizinische Forschung c/o Abteilung für Kardiologie, Klinik Floridsdorf
RECRUITING

Vienna, 1210, Austria
Kepler Universitätsklinikum GmbH Klinik für Innere Medizin 1 - Kardiologie und Internistische Intensivmedizin
RECRUITING

Linz, 4021, Austria
Klinik Detmold
RECRUITING

Detmold, 32756, Germany
Klinik Landstrasse, Kardiologie
RECRUITING

Vienna, 1030, Austria
Klinikum Ahaus
RECRUITING

Ahaus, 48683, Germany
Klinikum Konstanz
RECRUITING

Konstanz, 78464, Germany
Klinikum Wels-Grieskirchen GmbH+B18
TERMINATED

Kepler Universitätsklinikum Gmb+, 4600, Austria
Landesklinikum Mistelbach - Gänserndorf
RECRUITING

Mistelbach, 2130, Austria
Lipidambulanz Charite Campus Virchow
RECRUITING

Berlin, 13353, Germany
Lipidambulanz Uniklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
MEDICLIN Reha-Zentrum Spreewald
RECRUITING

Burg, 03096, Germany
Meduni Wien, Endokrinologie und Diabetes
RECRUITING

Vienna, 1090, Austria
Meduni Wien, Kardiologie
RECRUITING

Vienna, 1090, Austria
Molinette Università to
RECRUITING

Torino, 10126, Italy
Ordination
RECRUITING

Mattersburg, 7210, Austria
Ordination Dr. med. univ. Evelyn Fließer-Görzer
RECRUITING

Saint Stefan Bei Graz, 8511, Austria
Ordination Univ.-Prof. Dr. Kurt Huber
TERMINATED

Vienna, 1060, Austria
Osp della Misericordia
RECRUITING

Grosseto, 58100, Italy
Osp infermi di rivoli
RECRUITING

Rivoli, 10098, Italy
Osp. "San Paolo"
RECRUITING

Bari, 70123, Italy
Osp. "Vito Fazzi"
RECRUITING

Lecce, 73100, Italy
Osp. SS Annunziata
RECRUITING

Chieti, 66100, Italy
Osp. Sant'Anna di Cona
RECRUITING

Ferrara, 44124, Italy
Osp. Santa Maria delle Croci
RECRUITING

Ravenna, 48121, Italy
Osp. di Cattinara
RECRUITING

Trieste, 34149, Italy
Osp. santo spirito
RECRUITING

Casale Monferrato, 15033, Italy
Ospedale Mater Salutis
RECRUITING

Legnagno, 37045, Italy
Ospedale Mauriziano
RECRUITING

Torino, 10128, Italy
Ospedale PederzoliItlit
RECRUITING

Peschiera, 37019, Italy
Ospedale Pertini
RECRUITING

Roma, 00157, Italy
Ospedale Sant'Andrea
RECRUITING

Roma, 00189, Italy
Ospedale Sant'Anna e san Sebastiano
RECRUITING

Caserta, 81100, Italy
Ospedale di Bolzano
RECRUITING

Bolzano, 39100, Italy
Ospedale di Mantova
RECRUITING

Mantua, 46100, Italy
Ospedale di Portogruaro
RECRUITING

Venezia, 30026, Italy
PO Nuovo Umberti I
RECRUITING

Enna, 94100, Italy
Parkkardiologie, kard. Gemeinschaftspraxis
RECRUITING

Stanhsdorf B. Berlin, 14532, Germany
Policlinico "Riuniti"
RECRUITING

Foggia, 71122, Italy
Policlinico Federico II
RECRUITING

Naples, 80131, Italy
Policlinico G. Martino
RECRUITING

Messina, 98124, Italy
Policlinico Modena
RECRUITING

Modena, 41125, Italy
Policlinico P. Giaccone
RECRUITING

Palermo, 90127, Italy
Policlinico San Martino
RECRUITING

Genova, 16132, Italy
Policlinico Tor Vergata
RECRUITING

Roma, 00133, Italy
Policlinico Umberto I
RECRUITING

Rome, 00161, Italy
Policlinnico Mater Domini
RECRUITING

Catanzaro, 88100, Italy
Praxis
RECRUITING

Greiz, 07973, Germany
Praxis Dr. Methfessel
RECRUITING

Dresden, 01159, Germany
Praxis Dr. Norbert Schön
RECRUITING

Mühldorf A. Inn, 84453, Germany
Praxis Gesundheitszentrum Moos 15 (Praxis Prof. Lichtenauer)
RECRUITING

Salzburg, 5020, Austria
Praxis W. Almohamed
RECRUITING

Alsfed, 36304, Germany
Praxis für Kardiologie Aachen
RECRUITING

Aachen, 52062, Germany
Presidio Ospedaliero
RECRUITING

Pescara, 65124, Italy
Pôle hospitalier Jolimont
RECRUITING

La Louvrière, 7100, Belgium
S. Maria della Misericordia
RECRUITING

Perugia, 06129, Italy
Sierrallana Hospital
RECRUITING

Cantabria, 39300, Spain
Spedali Civili di Brescia
RECRUITING

Brescia, 25123, Italy
Spedali Riuniti
RECRUITING

Livorno, 57124, Italy
UZ Brussel
RECRUITING

Brussels, 1090, Belgium
UZ Gent
ACTIVE_NOT_RECRUITING

Ghent, 9000, Belgium
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
UZA (Antwerp University Hospital)
RECRUITING

Antwerp, 2650, Belgium
Uni-Klinik Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Uniklinik Graz, Endokrinologie und Diabetes
RECRUITING

Graz, 8036, Austria
Uniklinik Graz, Kardiologie
RECRUITING

Graz, 8036, Austria
Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Z.O.L - Campus St. Jan
RECRUITING

Genk, 3600, Belgium
Zentrum für Klinische Studien Dr. Hanusch GmbH
TERMINATED

Vienna, 1060, Austria
Zentrum für klinische Studien Bad Homburg
RECRUITING

Bad Homburg, 61348, Germany
ndgl.; viele Kombinationstherapien
TERMINATED

Gräfenhainichen, 06773, Germany

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