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Lung cancer combo trial halted early

NCT ID NCT05469178

Terminated Disease control Sponsor: BerGenBio ASA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tested a new drug called bemcentinib added to standard chemotherapy and immunotherapy for people with advanced non-squamous lung cancer. The study aimed to check safety and find the right dose, but it was terminated early. Only 26 people took part, so we cannot draw firm conclusions about how well it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bemcentinib (a drug taken orally) combined with pembrolizumab, carboplatin, and pemetrexed (standard chemotherapy and immunotherapy)
What this could lead to
If it had succeeded, this could have pointed toward a new treatment option for people with a specific genetic mutation (STK11) in advanced lung cancer.
What could go wrong
The trial was terminated early, so results are limited. It was a small, early-phase study (Phase 1b/2a) focused on safety, not proof of effectiveness. The combination may also cause side effects from multiple drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

  • Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi

    Bologna, 40138, Italy

  • Centre Antoine Lacassagne

    Nice, 6189, France

  • Duke University Medical Center - Duke Cancer Center

    Durham, North Carolina, 27710, United States

  • Fejer County St. Gyorgy Hospital

    Székesfehérvár, 8000, Hungary

  • Fundacion Instituto Valenciano de Oncologia (FIVO)

    Valencia, 46009, Spain

  • General Hospital of Athens Alexandra, Department of the Clinical Therapeutics, Medical Oncology Unit

    Athens, 11528, Greece

  • Henry Dunant Hospital Center, 4th Oncology Department

    Athens, 115 26, Greece

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Universitari Germans Trias i Pujol

    Badalona, 8916, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron

    Barcelona, 8035, Spain

  • Hôpital Europeen Georges Pompidou (HEGP), Service de cancérologie

    Paris, 75015, France

  • Hôpital prive du Confluent SAS, Departement d'oncologie

    Nantes, 44277, France

  • IFO Regina Elena

    Rome, 144, Italy

  • IRCCS - Istituto Europeo di Oncologia IEO

    Milan, 20141, Italy

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Institut Gustave Roussy, Service de médecine

    Villejuif, 94805, France

  • Instytut Centrum Zdrowia Matki Polki (ICZMP)

    Lodz, 93-338, Poland

  • MD Anderson Cancer Center, Oncology service

    Madrid, 28033, Spain

  • Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland

    Baltimore, Maryland, 21201, United States

  • MedPolonia Sp z oo

    Poznan, 60693, Poland

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida, 33140, United States

  • Orszagos Koranyi Pulmonologiai Intezet

    Budapest, 1121, Hungary

  • Ospedale San Luca

    Lucca, 55100, Italy

  • Semmelweis University- Department of Pulmonology

    Budapest, 1083, Hungary

  • Sotiria General Hospital of Chest Diseases, 3rd Department of Internal Medicine, Oncology Unit

    Athens, 115 27, Greece

  • Tennessee Oncology PLLC

    Nashville, Tennessee, 37203, United States

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University General Hospital of Larissa, Oncology Clinic

    Larissa, 41110, Greece

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

    Lublin, 20090, Poland

  • Uniwersytecki Szpital Kliniczny w Bialymstoku, II Klinika Chorob Pluc, raka płuca i chorób wewnętrznych

    Bialystok, 15-540, Poland

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