New pill combo aims to fight advanced kidney cancer

NCT ID NCT07489495

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This Phase 3 trial is testing whether adding the drug zanzalintinib to belzutifan helps people with advanced kidney cancer live longer and keep the cancer from growing. About 758 participants who have already tried standard treatments will receive either the combination or belzutifan alone. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belzutifan and zanzalintinib (targeted therapy pills)
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced kidney cancer who have run out of standard therapies, potentially helping them live longer and delay cancer growth.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The combination may not work better than belzutifan alone, and side effects from adding zanzalintinib could be more severe.

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Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma renal cell adenocarcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, RENAL CELL

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AIDPORT Sp. z o.o. ( Site 2118)
RECRUITING

Skórzewo, Greater Poland Voivodeship, 60-185, Poland
AO Santa Maria della Misericordia ( Site 1805)
RECRUITING

Perugia, 06132, Italy
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1401)
RECRUITING

Athens, Attica, 124 62, Greece
Aarhus Universitetshospital, Skejby ( Site 1001)
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Adana Medical Park Seyhan Hastanesi ( Site 2505)
RECRUITING

Adana, 01140, Turkey (Türkiye)
Alexandra General Hospital of Athens ( Site 1400)
RECRUITING

Athens, Attica, 115 28, Greece
Ankara University Health Practice and Research Hospitals ( Site 2506)
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Asan Medical Center ( Site 2901)
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Universitaria Careggi ( Site 1807)
RECRUITING

Florence, Tuscany, 50134, Italy
Bradfordhill ( Site 0400)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CEDOES ( Site 0303)
RECRUITING

Vitória, Espírito Santo, 29055-450, Brazil
CHU Angers ( Site 1204)
RECRUITING

Angers, Maine-et-Loire, 49933, France
CHU de Saint-Etienne ( Site 1202)
RECRUITING

Saint Priest En Jarez, Pays de la Loire Region, 42271, France
COE (Centro Oncológico de Excelencia) ( Site 0259)
RECRUITING

San Juan, J5402BGA, Argentina
Centre Antoine Lacassagne ( Site 1209)
RECRUITING

Nice, Alpes-Maritimes, 06189, France
Centro Oncologico Korben ( Site 0254)
RECRUITING

CABA, Buenos Aires, C1426AHB, Argentina
Centro Oncológico Riojano Integral ( Site 0256)
RECRUITING

La Rioja, X5004BAL, Argentina
Centro Privado de RMI Río Cuarto S.A. II ( Site 0255)
RECRUITING

Río Cuarto, Córdoba Province, X5800ALB, Argentina
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1312)
RECRUITING

Berlin, 10117, Germany
Clinique Victor Hugo Le Mans-Oncology-Radiotherapy ( Site 1203)
RECRUITING

Le Mans, Pays de la Loire Region, 72000, France
Clínica Puerto Montt ( Site 0404)
RECRUITING

Port Montt, Los Lagos Region, 5500243, Chile
Fakulti poliklinika ( Site 0906)
RECRUITING

Prague, 128 08, Czechia
Fakultni nemocnice Hradec Kralove ( Site 0902)
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Ostrava ( Site 0904)
RECRUITING

Ostrava, Ostrava Mesto, 708 52, Czechia
Fakultni nemocnice v Motole ( Site 0900)
RECRUITING

Prague, 150 06, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1800)
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801)
RECRUITING

Roma, 00168, Italy
Fundacion Arturo Lopez Perez ( Site 0401)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Fundación Instituto Valenciano de Oncología ( Site 2307)
RECRUITING

Valencia, 46009, Spain
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0302)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2301)
RECRUITING

Madrid, Madrid, Comunidad de, 28007, Spain
Hacettepe Universite Hastaneleri ( Site 2500)
RECRUITING

Sıhhiye, Ankara, 06230, Turkey (Türkiye)
Haga Ziekenhuis locatie Leyweg ( Site 1906)
RECRUITING

The Hague, South Holland, 2545 AA, Netherlands
Herlev Hospital ( Site 1002)
RECRUITING

Herlev, Capital Region, 2730, Denmark
Hope - Humanizacao Em Oncologia, Pesquisa E Ensino ( Site 0306)
RECRUITING

Ribeirão Preto, São Paulo, 14026-610, Brazil
Hopital Europeen Marseille ( Site 1216)
RECRUITING

Marseille, Bouches-du-Rhone, 13003, France
Hospital Insular de Gran Canaria ( Site 2308)
RECRUITING

Las Palmas, 35016, Spain
Hospital Italiano de Buenos Aires ( Site 0253)
RECRUITING

Ciudad de Buenos Aires, Buenos Aires, 1181, Argentina
Hospital Universitari Vall d'Hebron ( Site 2303)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 2300)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen del Rocio ( Site 2306)
RECRUITING

Seville, Andalusia, 41013, Spain
IC La Serena Research ( Site 0405)
RECRUITING

La Serena, Coquimbo Region, 1720430, Chile
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1809)
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1803)
RECRUITING

Bologna, 40138, Italy
Institut Català d'Oncologia - L'Hospitalet ( Site 2305)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Instituto Alexander Fleming ( Site 0252)
RECRUITING

CABA, C1426ANZ, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0250)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Instituto de Oncología de Rosario ( Site 0257)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina
Instituto do Câncer e Transplante de Curitiba ( Site 0300)
RECRUITING

Curitiba, Paraná, 80510-130, Brazil
Istituto Clinico Humanitas ( Site 1808)
RECRUITING

Rozzano, Milano, 20089, Italy
Istituto Nazionale Tumori Regina Elena ( Site 1804)
RECRUITING

Roma, 00144, Italy
Koc Universitesi Hastanesi ( Site 2501)
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1215)
RECRUITING

Toulouse, Haute-Garonne, 31059, France
Liga Norte Riograndense Contra o Câncer ( Site 0307)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
MTZ Clinical Research Powered by Pratia ( Site 2107)
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
Maastricht UMC+ ( Site 1901)
RECRUITING

Maastricht, Limburg, 6229 HX, Netherlands
Macquarie University ( Site 2700)
SUSPENDED

Macquarie University, New South Wales, 2109, Australia
Masarykuv onkologicky ustav ( Site 0903)
RECRUITING

Brno, Brno-mesto, 656 53, Czechia
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
RECRUITING

Siedlce, Masovian Voivodeship, 08-110, Poland
Meir Medical Center. ( Site 1603)
RECRUITING

Kfar Saba, 4428164, Israel
Metropolitan Hospital ( Site 1402)
RECRUITING

Athens, Attica, 185 47, Greece
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2106)
RECRUITING

Gliwice, Silesian Voivodeship, 44-102, Poland
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL) ( Site 1900)
RECRUITING

Amsterdam, North Holland, 1066 CX, Netherlands
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0102)
RECRUITING

Marietta, Georgia, 30060, United States
ONCOCENTRO APYS ( Site 0403)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Peter MacCallum Cancer Centre ( Site 2702)
SUSPENDED

Melbourne, Victoria, 3000, Australia
Pratia MCM Krakow ( Site 2115)
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Rabin Medical Center ( Site 1602)
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus ( Site 1600)
RECRUITING

Haifa, 3109601, Israel
Samsung Medical Center ( Site 2902)
RECRUITING

Seoul, 06351, South Korea
Sanatorio Parque ( Site 0251)
RECRUITING

Rosario, Santa Fe Province, S2000DSV, Argentina
Severance Hospital, Yonsei University Health System ( Site 2903)
RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center ( Site 1601)
RECRUITING

Ramat Gan, 5265601, Israel
The Christie Hospital NHS Foundation Trust ( Site 2601)
RECRUITING

Withington, Manchester, M20 4BX, United Kingdom
The West Clinic, P.C. ( Site 0115)
RECRUITING

Germantown, Tennessee, 38138, United States
Trakya University Medical Faculty Hospital ( Site 2502)
RECRUITING

Edirne, 22030, Turkey (Türkiye)
Universitätsklinikum Jena ( Site 1313)
RECRUITING

Jena, Thuringia, 07747, Germany
klinikum rechts der isar der technischen universität münchen ( Site 1315)
RECRUITING

Munich, Bavaria, 81675, Germany

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