New pill combo aims to fight advanced kidney cancer
NCT ID NCT07489495
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial is testing whether adding the drug zanzalintinib to belzutifan helps people with advanced kidney cancer live longer and keep the cancer from growing. About 758 participants who have already tried standard treatments will receive either the combination or belzutifan alone. The study is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
belzutifan and zanzalintinib (targeted therapy pills)
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced kidney cancer who have run out of standard therapies, potentially helping them live longer and delay cancer growth.
What could go wrong
This is an early-stage Phase 3 trial, so results are not guaranteed. The combination may not work better than belzutifan alone, and side effects from adding zanzalintinib could be more severe.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AIDPORT Sp. z o.o. ( Site 2118)
RECRUITINGSkórzewo, Greater Poland Voivodeship, 60-185, Poland
Contact Phone: •••-•••-••••
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ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1401)
RECRUITINGAthens, Attica, 124 62, Greece
Contact Phone: •••-•••-••••
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Aarhus Universitetshospital, Skejby ( Site 1001)
RECRUITINGAarhus, Central Jutland, 8200, Denmark
Contact Phone: •••-•••-••••
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Asan Medical Center ( Site 2901)
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-••••
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CHU Angers ( Site 1204)
RECRUITINGAngers, Maine-et-Loire, 49933, France
Contact Phone: •••-•••-••••
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Centro Oncologico Korben ( Site 0254)
RECRUITINGCABA, Buenos Aires, C1426AHB, Argentina
Contact Phone: •••-•••-••••
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Centro Oncológico Riojano Integral ( Site 0256)
RECRUITINGLa Rioja, X5004BAL, Argentina
Contact Phone: •••-•••-••••
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Centro Privado de RMI Río Cuarto S.A. II ( Site 0255)
RECRUITINGRío Cuarto, Córdoba Province, X5800ALB, Argentina
Contact Phone: •••-•••-••••
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Fakultni nemocnice Ostrava ( Site 0904)
RECRUITINGOstrava, Ostrava Mesto, 708 52, Czechia
Contact Phone: •••-•••-••••
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Fakultni nemocnice v Motole ( Site 0900)
RECRUITINGPrague, 150 06, Czechia
Contact Phone: •••-•••-••••
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Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1800)
RECRUITINGMilan, 20133, Italy
Contact Phone: •••-•••-••••
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801)
RECRUITINGRoma, 00168, Italy
Contact Phone: •••-•••-••••
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Fundación Instituto Valenciano de Oncología ( Site 2307)
RECRUITINGValencia, 46009, Spain
Contact Phone: •••-•••-••••
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HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2301)
RECRUITINGMadrid, Madrid, Comunidad de, 28007, Spain
Contact Phone: •••-•••-••••
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Haga Ziekenhuis locatie Leyweg ( Site 1906)
RECRUITINGThe Hague, South Holland, 2545 AA, Netherlands
Contact Phone: •••-•••-••••
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Herlev Hospital ( Site 1002)
RECRUITINGHerlev, Capital Region, 2730, Denmark
Contact Phone: •••-•••-••••
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Hopital Europeen Marseille ( Site 1216)
RECRUITINGMarseille, Bouches-du-Rhone, 13003, France
Contact Phone: •••-•••-••••
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Hospital Insular de Gran Canaria ( Site 2308)
RECRUITINGLas Palmas, 35016, Spain
Contact Phone: •••-•••-••••
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Hospital Universitari Vall d'Hebron ( Site 2303)
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-••••
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Hospital Universitario 12 de Octubre ( Site 2300)
RECRUITINGMadrid, 28041, Spain
Contact Phone: •••-•••-••••
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Hospital Universitario Virgen del Rocio ( Site 2306)
RECRUITINGSeville, Andalusia, 41013, Spain
Contact Phone: •••-•••-••••
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1809)
RECRUITINGMeldola, Emilia-Romagna, 47014, Italy
Contact Phone: •••-•••-••••
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Institut Català d'Oncologia - L'Hospitalet ( Site 2305)
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
Contact Phone: •••-•••-••••
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Instituto Alexander Fleming ( Site 0252)
RECRUITINGCABA, C1426ANZ, Argentina
Contact Phone: •••-•••-••••
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Instituto de Investigaciones Clinicas Mar del Plata ( Site 0250)
RECRUITINGMar del Plata, Buenos Aires, B7600FZO, Argentina
Contact Phone: •••-•••-••••
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Instituto de Oncología de Rosario ( Site 0257)
RECRUITINGRosario, Santa Fe Province, S2000KZE, Argentina
Contact Phone: •••-•••-••••
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MTZ Clinical Research Powered by Pratia ( Site 2107)
RECRUITINGWarsaw, Masovian Voivodeship, 02-172, Poland
Contact Phone: •••-•••-••••
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Macquarie University ( Site 2700)
SUSPENDEDMacquarie University, New South Wales, 2109, Australia
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Masarykuv onkologicky ustav ( Site 0903)
RECRUITINGBrno, Brno-mesto, 656 53, Czechia
Contact Phone: •••-•••-••••
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Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
RECRUITINGSiedlce, Masovian Voivodeship, 08-110, Poland
Contact Phone: •••-•••-••••
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Meir Medical Center. ( Site 1603)
RECRUITINGKfar Saba, 4428164, Israel
Contact Phone: •••-•••-••••
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Metropolitan Hospital ( Site 1402)
RECRUITINGAthens, Attica, 185 47, Greece
Contact Phone: •••-•••-••••
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Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL) ( Site 1900)
RECRUITINGAmsterdam, North Holland, 1066 CX, Netherlands
Contact Phone: •••-•••-••••
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Oncopole Claudius Regaud ( Site 1215)
RECRUITINGToulouse, Haute-Garonne, 31059, France
Contact Phone: •••-•••-••••
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Pratia MCM Krakow ( Site 2115)
RECRUITINGKrakow, Lesser Poland Voivodeship, 30-727, Poland
Contact Phone: •••-•••-••••
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Rabin Medical Center ( Site 1602)
RECRUITINGPetah Tikva, 4941492, Israel
Contact Phone: •••-•••-••••
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Rambam Health Care Campus ( Site 1600)
RECRUITINGHaifa, 3109601, Israel
Contact Phone: •••-•••-••••
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Samsung Medical Center ( Site 2902)
RECRUITINGSeoul, 06351, South Korea
Contact Phone: •••-•••-••••
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Sanatorio Parque ( Site 0251)
RECRUITINGRosario, Santa Fe Province, S2000DSV, Argentina
Contact Phone: •••-•••-••••
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Severance Hospital, Yonsei University Health System ( Site 2903)
RECRUITINGSeoul, 03722, South Korea
Contact Phone: •••-•••-••••
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Sheba Medical Center ( Site 1601)
RECRUITINGRamat Gan, 5265601, Israel
Contact Phone: •••-•••-••••