New drug may help stem cell transplant patients avoid extra immune suppression

NCT ID NCT05996627

Recruiting now Disease control Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 31 times

Summary

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD) from getting worse after a stem cell transplant. cGVHD is a common complication where the donor's immune cells attack the patient's body. The trial will compare belumosudil to a placebo in 82 adults who already have mild cGVHD symptoms. The goal is to see if the drug can delay or avoid the need for stronger immune-suppressing medications.

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Contacts and locations

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Locations

City of Hope
NOT_YET_RECRUITING

Duarte, California, 91010, United States

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Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States

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Fred Hutch/University of Washington Cancer Consortium
RECRUITING

Seattle, Washington, 98109, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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Conditions

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CHRONIC GRAFT VERSUS HOST DISEASE