Gene type may affect how cancer drug works in patients

NCT ID NCT02680795

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 29 times

Summary

This study looked at how the cancer drug belinostat is processed in the body by people with advanced solid tumors or blood cancers. Researchers wanted to see if a person's genetic makeup (specifically the UGT1A1 gene) changes how the drug works or causes side effects. The study included 17 patients whose cancer had returned or stopped responding to treatment.

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Contacts and locations

Locations

  • Gabrail Cancer Center Research

    Canton, Ohio, 44718, United States

  • John Wayne Cancer Institute @ Providence Saint John's Health Center

    Santa Monica, California, 90404, United States

  • The Oncology Institute of Hope and Innovation

    Whittier, California, 90603, United States

Conditions

Explore the condition pages connected to this study.