Teen kidney transplant patients may get a better drug option

NCT ID NCT04877288

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether switching teen kidney transplant recipients (ages 12-17) from standard immunosuppressants (calcineurin inhibitors) to belatacept (Nulojix) can improve kidney function and medication adherence. About 102 teens who received a kidney transplant at least 6 months ago will be randomly assigned to either switch to belatacept or stay on their current regimen. The main goal is to see if more patients on belatacept have a working kidney with good function after 2 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

belatacept (Nulojix)

What this could lead to

If successful, this could offer teen kidney transplant recipients a better-tolerated immunosuppressant that preserves kidney function longer and is easier to stick with.

What could go wrong

This is a Phase 3 trial, but it's relatively small (102 participants) and open-label, which can bias results. Belatacept may not work for everyone and carries risks like infection or rejection.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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RENAL ALLOGRAFT RECIPIENTS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universita
RECRUITING

Paris, 75019, France

Contact Phone: •••-•••-••••
Bordeaux University Hospital - Pellegrin-Pediatrics
RECRUITING

Bordeaux, 33076, France

Contact Phone: •••-•••-••••
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING

Nantes, Loire-Atlantique, 44093, France

Contact Phone: •••-•••-••••
Emma Children (AMC)
RECRUITING

Amsterdam, 1105 AZ, Netherlands

Contact Phone: •••-•••-••••
Hopital De La Timone
RECRUITING

Marseille, 13005, France

Contact Phone: •••-•••-••••
Hopital Necker
RECRUITING

Paris, 75015, France

Contact Phone: •••-•••-••••
Hospices Civils de Lyon - Hôpital Femme Mère Enfant-néphrologie pédiatrique
RECRUITING

Bron, 69677, France

Contact Phone: •••-•••-••••
Hospital Italiano de Buenos Aires
RECRUITING

ABB, Buenos Aires F.D., C1199ABB, Argentina

Contact Phone: •••-•••-••••
IRCCS Istituto Giannina Gaslini
RECRUITING

Genoa, Liguria, 16147, Italy

Contact Phone: •••-•••-••••
Local Institution - 0001
COMPLETED

Barcelona, 08035, Spain
Local Institution - 0003
COMPLETED

Seville, 41013, Spain
Local Institution - 0008
COMPLETED

Manchester, M13 9WL, United Kingdom
Local Institution - 0011
COMPLETED

Hamburg, 20246, Germany
Local Institution - 0012
COMPLETED

Rivas-Vaciamadrid, 28523, Spain
Local Institution - 0014
WITHDRAWN

Washington D.C., District of Columbia, 20010, United States
Local Institution - 0017
WITHDRAWN

Baltimore, Maryland, 21287, United States
Local Institution - 0022
WITHDRAWN

Hollywood, Florida, 33021, United States
Local Institution - 0024
WITHDRAWN

Durham, North Carolina, 27710, United States
Local Institution - 0025
WITHDRAWN

Cincinnati, Ohio, 45229, United States
Local Institution - 0026
RECRUITING

Heidelberg, 69120, Germany

Contact
Local Institution - 0030
WITHDRAWN

Milan, 20122, Italy
Local Institution - 0033
WITHDRAWN

Chicago, Illinois, 60611, United States
Local Institution - 0038
WITHDRAWN

Seattle, Washington, 98105, United States
Local Institution - 0041
WITHDRAWN

Los Angeles, California, 90095, United States
Local Institution - 0042
WITHDRAWN

Birmingham, Alabama, 35233, United States
Local Institution - 0043
WITHDRAWN

St Louis, Missouri, 63110, United States
Local Institution - 0044
WITHDRAWN

Boston, Massachusetts, 02115, United States
Local Institution - 0045
WITHDRAWN

Miami, Florida, 33136, United States
Local Institution - 0048
WITHDRAWN

Cleveland, Ohio, 44124, United States
Local Institution - 0049
WITHDRAWN

Atlanta, Georgia, 30322, United States
Local Institution - 0052
WITHDRAWN

Portland, Oregon, 97239, United States
Local Institution - 0061
WITHDRAWN

Oslo, N-0027, Norway
Local Institution - 0062
NOT_YET_RECRUITING

Buenos Aires, 1425, Argentina

Contact
Ospedale Regina Margherita-S.C Nefrologia, Dialisi e Trapianto Renale
RECRUITING

Torino, 10126, Italy

Contact Phone: •••-•••-••••
Queen's Medical Centre, Nottingham University Hospitals-Children's Clinical Research Team
RECRUITING

Nottingham, NG7 2UH, United Kingdom

Contact Phone: •••-•••-••••
UZ Gent-Paediatric Nephrology and Rheumatology Department
RECRUITING

Ghent, 9000, Belgium

Contact Phone: •••-•••-••••
Universitaetsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45122, Germany

Contact Phone: •••-•••-••••
Universitaetsklinikum Koeln-Klinik und Poliklinik für Kinder- und Jugendmedizin, Abteilung für Pädia
RECRUITING

Cologne, 50937, Germany

Contact Phone: •••-•••-••••