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Why some beekeepers shrug off stings while others react

NCT ID NCT06156046

Knowledge-focused Sponsor: University Hospital Plymouth NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Beekeepers get stung often, and many develop antibodies to bee venom. Only a few have severe allergic reactions. This study compares blood and skin test results from beekeepers who tolerate stings, beekeepers who are allergic, and people who are not beekeepers. Researchers aim to find what protects tolerant beekeepers from anaphylaxis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers identify the blood factors that protect tolerant beekeepers, this could point toward new ways to prevent or treat severe bee sting allergies.
What could go wrong
This is an observational study, so it can only find patterns, not prove cause and effect. The findings may not apply to people who are not beekeepers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Group 1 inclusion criteria. Individuals naive to beekeeping (\<2 previous bee stings, none in the last 24 months). No history of anaphylaxis to bee stings. Group 2 inclusion criteria. Beekeepers with \> approximately 10 stings/year who have been beekeeping for \>3 years. No history of anaphylaxis to bee stings. Group 3 inclusion criteria Beekeepers with diagnosis of anaphylaxis to bee venom in the last 12 months who are sensitised to bee venom (as evidenced by positive specific IgE and positive skin test to bee venom).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Group 1 inclusion criteria. * Individuals naive to beekeeping (\<2 previous bee stings, none in the last 24 months) * no history of anaphylaxis to stings. Group 2 inclusion criteria. * Beekeepers with \> approximately 10 stings/year who have been beekeeping for \>3 years. * No history of anaphylaxis to bee venom. Group 3 inclusion criteria * Beekeepers with diagnosis of anaphylaxis to bee venom in the last 12 months who are sensitised to bee venom (as evidenced by positive specific IgE and positive skin test to bee venom) Exclusion Criteria: * Unable to understand protocol/consent. * Unable to commit to follow up visits. * Participants with a known history of mastocytosis or under investigation for suspected mastocytosis. * Participants undergoing desensitisation treatment to bee venom before the first visit. * Participants being treatment with immunosuppressive medications. being treatment with immunosuppressive medications.

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Conditions

The condition(s) this trial relates to.

anaphylaxis venom allergy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bee sting

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Derriford Hospital - University Hospitals Plymouth

    RECRUITING

    Plymouth, Devon, PL65FP, United Kingdom

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