CAR-T therapy for multiple myeloma shows promise but trial ends early

NCT ID NCT04318327

First seen Apr 04, 2026 · Last updated May 08, 2026 · Updated 7 times

Summary

This early-phase study tested a new type of immunotherapy called CAR-T cells, which are the patient's own immune cells modified to attack a protein called BCMA found on myeloma cells. The trial included adults with multiple myeloma that had not responded to at least two prior treatments. The main goals were to check safety and see if the treatment could shrink the cancer. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Cente

    Boston, Massachusetts, 02215, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Novartis Investigative Site

    Melbourne, Victoria, 3004, Australia

  • Novartis Investigative Site

    Ramat Gan, 5265601, Israel

  • Novartis Investigative Site

    Tel Aviv, 6423906, Israel

  • Novartis Investigative Site

    Singapore, 119074, Singapore

  • Novartis Investigative Site

    Singapore, 169608, Singapore

  • Uni of Chi Medi Ctr Hema and Onco

    Chicago, Illinois, 60637, United States

Conditions

Explore the condition pages connected to this study.