New targeted pill shows promise against tough lung cancers

NCT ID NCT05099172

Ongoing Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 24 times

Summary

This study tests a new drug, BAY 2927088, for people with advanced non-small cell lung cancer that has specific changes (mutations) in the EGFR or HER2 genes. The drug aims to block these abnormal proteins to stop cancer growth. The trial involves about 370 participants and will first find a safe dose, then check how well the drug works by measuring tumor shrinkage.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

AZ Delta | Clinical Trial Center - Pneumology

Roeselare, West-Flanders, 8800, Belgium
Aichi Cancer Center Hospital

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center | Oncology

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Azienda Ospedaliero Universitaria Parma - SC Oncologia Medica

Parma, Emilia-Romagna, 43126, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica

Orbassano, Piedmont, 10043, Italy
Banner MD Anderson Cancer Center at Banner Gateway Medical Center

Gilbert, Arizona, 85234, United States
Beijing Cancer Hospital - Oncology Department

Beijing, Beijing Municipality, 100142, China
Beijing Hospital

Beijing, Beijing Municipality, 100730, China
Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit

Detroit, Michigan, 48202, United States
Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia

Verona, 37134, Italy
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati

Aviano, Friuli Venezia Giulia, 33081, Italy
Chaim Sheba Medical Center

Ramat Gan, 5262000, Israel
Chang Gung Memorial Hospital at Linkou

Taoyuan, 33305, Taiwan
Chi-Mei Medical Center, Liouyine

Tainan, 73657, Taiwan
Chungbuk National University Hospital

Cheongju-si, North Chungcheong, 28644, South Korea
City of Hope - Duarte Cancer Center

Duarte, California, 91010, United States
Curie Oncology | Mount Elizabeth Novena

Singapore, 329563, Singapore
Dana-Farber Cancer Institute - Oncology Department

Boston, Massachusetts, 02215, United States
Emory Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Erasmus University Medical Center | Research Department - Lung Diseases

Rotterdam, South Holland, 3015 GD, Netherlands
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1

Milan, Lombardy, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Fase I

Rome, Lazio, 00128, Italy
Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China
Gustave Roussy - Departement Oncologie-Radiotherapie

Villejuif, Île-de-France Region, 94805, France
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150000, China
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hopital Nord Laennec - Oncologie medicale thoracique et digestive

Nantes, Pays de la Loire Region, 44093, France
Hospital Universitari Dexeus Grupo Quironsalud | Oncologia

Barcelona, 08028, Spain
Hospital Universitari Vall D Hebron | Oncologia

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz | Oncologia

Madrid, 28040, Spain
Hospital Universitario Hm Sanchinarro | Oncologia

Madrid, 28050, Spain
Hospital Universitario Y Politecnico La Fe | Oncologia

Valencia, 46026, Spain
Hospital de Base | Integrated Research Center

São José do Rio Preto, São Paulo, 15090-000, Brazil
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia

Rozzano, Lombardy, 20089, Italy
Hunan Cancer Hospital - Oncology Department

Changsha, Hunan, 410013, China
IPO Porto

Porto, 4200-072, Portugal
Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale

Bordeaux, New Aquitaine, 33000, France
Institut Catala D'oncologia | Hospitalet | Oncologia

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Institut Curie - Paris - Oncologie medicale

Paris, Île-de-France Region, 75248, France
Institut de Cancerologie Ouest - Saint Herblain - Oncologie medicale

Saint-Herblain, Pays de la Loire Region, 44800, France
Istituto Europeo di Oncologia s.r.l - Sviluppo di nuovi farmaci per Terapie Innovative

Milan, Lombardy, 20141, Italy
Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan
Kindai University Hospital

Sakai, Osaka, 590-0197, Japan
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica

Natal, Rio Grande do Norte, 59040-000, Brazil
NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School

Nanjing, Jiangsu, 210008, China
NYU Langone Hospital - Long Island - Urology

Mineola, New York, 11501, United States
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cancer Center Singapore - Oncology Department

Singapore, 168583, Singapore
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital

Taipei, 100, Taiwan
National University Hospital Medical Centre

Singapore, 119074, Singapore
Nederlands Kanker Instituut

Amsterdam, North Holland, 1066 CX, Netherlands
Okayama University Hospital

Okayama, 700-8558, Japan
Osaka International Cancer Institute

Osaka, Osaka, 541-8567, Japan
Prince of Wales Hospital

Hong Kong, Hong Kong SAR, 00000, Hong Kong
Qilu Hosp., Shandong Univ.

Jinan, Shandong, 250012, China
Queen Mary Hospital

Hong Kong, Hong Kong SAR, 00000, Hong Kong
Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department

Petah Tikva, 4941492, Israel
Samsung Medical Center - Oncology Department

Seoul, 6351, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggido, 13620, South Korea
Seoul National University Hospital

Seoul, Seoul Teugbyeolsi, 3080, South Korea
Severance Hospital, Yonsei University Health System - Oncology Department

Seoul, Seoul Teugbyeolsi, 03722, South Korea
Shandong University - Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Shanghai Chest Hospital, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, 200030, China
Shizuoka Cancer Center

Sunto, Shizuoka, 411-8777, Japan
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department

Hangzhou, Zhejiang, 310016, China
St.Vincent's Hospital

Suwon, Gyeonggido, 16247, South Korea
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Tennessee Oncology - Nashville Centennial Clinic

Nashville, Tennessee, 37203, United States
The Center for Cancer and Blood Disorders

Bethesda, Maryland, 20817, United States
The University of Texas MD Anderson Cancer Center - Texas Medical Center

Houston, Texas, 77030, United States
Tottori University Hospital

Yonago, Tottori, 683-8504, Japan
UNICANCER - Centre Leon-Berard (CLB) - Medical oncology

Lyon, Auvergne-Rhône-Alpes, 69373, France
UZ Leuven Gasthuisberg - Pneumology Department

Leuven, Vlaams-Brabant, 3000, Belgium
Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech

Wuhan, Hubei, 430023, China
Virginia Cancer Specialists, PC - Fairfax

Fairfax, Washington, 22031, United States
West China Hospital Sichuan University

Chengdu, Sichuan, 610041, China
Zhejiang Cancer Hospital

Hangzhou, Zhejiang, 310022, China
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, 317000, China

Conditions

Explore the condition pages connected to this study.

ADVANCED NON-SMALL-CELL LUNG CANCER EGFR MUTATION HER2 MUTATION