Blood pressure Drug's hidden effect on stress hormone revealed

NCT ID NCT06336356

Completed Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jan 09, 2026 · Last updated May 24, 2026 · Updated 23 times

Summary

This study looked at whether baxdrostat, a new drug for high blood pressure, changes how the body makes cortisol (a stress hormone). 48 adults with uncontrolled high blood pressure took baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and after a stimulation test to check for any effects on adrenal gland function.

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Contacts and locations

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Locations

Research Site

Phoenix, Arizona, 85018, United States
Research Site

Tempe, Arizona, 85281, United States
Research Site

Montclair, California, 91763, United States
Research Site

Tarzana, California, 91356, United States
Research Site

Tampa, Florida, 33612, United States
Research Site

Chicago, Illinois, 60643, United States
Research Site

Metairie, Louisiana, 70006, United States
Research Site

Houston, Texas, 77074, United States
Research Site

Houston, Texas, 77099, United States
Research Site

Norfolk, Virginia, 23502, United States

Conditions

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UNCONTROLLED HYPERTENSION