New drug combo shows promise for tough lung cancers

NCT ID NCT04681131

Completed Disease control Sponsor: BioAtla, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested a new drug called BA3011, alone or with an immunotherapy, in 85 adults with advanced non-small cell lung cancer that had worsened after standard treatments. The goal was to see if the drug could shrink tumors and how safe it was. The study is now complete, and results will show whether this approach deserves further testing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BA3011 (a targeted drug that seeks out and kills cancer cells) alone or with a PD-1 inhibitor (an immunotherapy)
What this could lead to: If successful, this could provide a new treatment option for people with advanced lung cancer who have stopped responding to standard therapies.
What could go wrong: This is a small, early-phase trial (85 people) with no control group, so results may not be definitive. Side effects from the drug combination could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Locations

"IRCCS Osp. Policlinico San Martino Pad Ex microbiologia, stanza 9, 1 piano."

Genoa, Liguria, 16132, Italy
American Institute of Research

Whittier, California, 90603, United States
Augusta University - Georgia Cancer Center

Augusta, Georgia, 30912, United States
Baptist Health Systems

Lexington, Kentucky, 40503, United States
Bioclinic Thessaloniki

Thessaloniki, 546 22, Greece
California Research Institute

Los Angeles, California, 90027, United States
Catalan Institute of Oncology, Hospital Duran i Reynals

Barcelona, Catalonia, 08908, Spain
Cedars-Sinai

Los Angeles, California, 90048, United States
City of Hope - Duarte

Duarte, California, 91010, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Comprehensive Cancer Centers of Nevada

Henderson, Nevada, 89014, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
European Institute of Oncology (IEO), IRCCS

Milan, 20141, Italy
European Interbalkan Medical Center

Thessaloniki, 570 01, Greece
FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, 28374, United States
Florida Cancer Specialist

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists & Research Institute

Fleming Island, Florida, 32003, United States
Florida Cancer Specialists & Research Institute

Fort Myers, Florida, 33916, United States
Gabrail Cancer Research Center

Canton, Ohio, 44718, United States
Hematology/Oncology Clinic

Baton Rouge, Louisiana, 70809, United States
Henry Dunant Hospital Center

Athens, 115 26, Greece
Hong Kong United Oncology Centre

Kowloon, Hong Kong
Hospital San Giuseppe Moscati

Avellino, 83100, Italy
Hospital Universitario Virgen de Valme

Seville, Andalusia, 41014, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, 08041, Spain
Hospital del Mar

Barcelona, Catalonia, 08003, Spain
ICON Cancer Centre

Hong Kong, Hong Kong
Institute of Genetics and Immunology GENIM

Lublin, Lublin Voivodeship, 20-609, Poland
Integrated University Hospital of Verona

Verona, 37126, Italy
Kaoshiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan
MD Anderson

Houston, Texas, 77030, United States
MED-Polonia, Sp. z o.o. (LLC)

Poznan, Greater Poland Voivodeship, 60-693, Poland
Maria Sklodowska-Curie - National Research Institute of Oncology

Warsaw, Masovian Voivodeship, 02-781, Poland
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Medical University of South Carolina- Hollings Cancer Center

Charleston, South Carolina, 29407, United States
Metropolitan Hospital Perseus Healthcare Group SA

Piraeus, 185 47, Greece
Moffitt Cancer Center

Tampa, Florida, 33612, United States
NYU Langone Health

New York, New York, 10016, United States
National Cheng Kung University Hospital

Tainan, Taiwan
National Taiwan University Hospital

Taipei, Taiwan
Norton Cancer Institute, Brownsboro Hospital Campus

Louisville, Kentucky, 40241, United States
OptumCare Cancer Care

Las Vegas, Nevada, 89169, United States
Polish Mother's Memorial Hospital-Research Institute

Lodz, Łódź Voivodeship, 93-338, Poland
Queen Mary Hospital

Hong Kong, Hong Kong
Roswell Park

Buffalo, New York, 14263, United States
Santa Maria delle Croci Hospital of Ravenna

Ravenna, 48121, Italy
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Specialistic Oncologic Hospital NU-MED

Tomaszów Mazowiecki, Łódź Voivodeship, 97-200, Poland
Taichung Veterans General Hospital

Taichung, Taiwan
Taipei Veterans General Hospital

Taipei, Taiwan
The Lindner Research Center at the Christ Hospital

Cincinnati, Ohio, 45219, United States
UPMC Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC Norris

Los Angeles, California, 90033, United States
University Hospital 12 de Octubre

Madrid, Madrid, 28041, Spain
University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center

Irvine, California, 92868, United States
University of California, San Diego (UCSD) - Moores Cancer Center

San Diego, California, 92093, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Michigan Comprehensive Cancer Center

Detroit, Michigan, 48202, United States

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