Targeted genetic therapy tested for common liver disease

NCT ID NCT05809934

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study tested an investigational injection called AZD2693 to see if it could treat NASH, a type of fatty liver disease that causes scarring. It specifically enrolled 220 adults with NASH and liver scarring who carry a certain gene (PNPLA3 148M) that increases their risk. The main goal was to see if the treatment could resolve the liver inflammation and prevent worsening of scarring after one year, compared to a placebo.

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Contacts and locations

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Locations

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Chandler, Arizona, 85224, United States
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Peoria, Arizona, 85381, United States
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Surprise, Arizona, 85378, United States
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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85715, United States
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Gardena, California, 90247, United States
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La Mesa, California, 91942, United States
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Lancaster, California, 93534, United States
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Los Angeles, California, 90057, United States
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Montclair, California, 91763, United States
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Orange, California, 92868, United States
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Rialto, California, 92377, United States
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Santa Ana, California, 92704, United States
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Boca Raton, Florida, 33434, United States
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Hialeah, Florida, 33016, United States
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Jacksonville, Florida, 32216, United States
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Port Orange, Florida, 32127, United States
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Winter Park, Florida, 32792, United States
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Marietta, Georgia, 30060, United States
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Topeka, Kansas, 66606, United States
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Detroit, Michigan, 48202, United States
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Las Vegas, Nevada, 89101, United States
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Westlake, Ohio, 44145, United States
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Chickasha, Oklahoma, 73018, United States
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Hershey, Pennsylvania, 17033, United States
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Summerville, South Carolina, 29485, United States
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Cordova, Tennessee, 38018, United States
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Austin, Texas, 78757, United States
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Brownsville, Texas, 78520, United States
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Denison, Texas, 75020, United States
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Edinburg, Texas, 78539, United States
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Houston, Texas, 77030, United States
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Red Oak, Texas, 75154, United States
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San Antonio, Texas, 78229, United States
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Sugar Land, Texas, 77479, United States
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Richmond, Virginia, 23249, United States
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Seattle, Washington, 98105, United States
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CABA, C1119ACN, Argentina
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CABA, C1426, Argentina
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Ciudad de Buenos Aires, 1280, Argentina
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Córdoba, X5000EPU, Argentina
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La Plata, 1900, Argentina
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Mar del Plata, B7600GNY, Argentina
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San Juan Bautista, 1888, Argentina
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Botucatu, 18618-687, Brazil
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Porto Alegre, 90035-000, Brazil
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Porto Alegre, 90035-903, Brazil
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Salvador, 40110-160, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 05403-000, Brazil
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Santiago, 7620157, Chile
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Santiago, 8380456, Chile
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Santiago, Chile
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Valdivia, 5110683, Chile
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Baotou, 014010, China
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Beijing, 100057, China
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Beijing, 100069, China
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Chengdu, 610072, China
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Fuzhou, 350005, China
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Guangzhou, 510515, China
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Hangzhou, 310003, China
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Liaocheng, 252000, China
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Nanchang, 330000, China
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Qingdao, 266011, China
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Shanghai, 200025, China
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Shanghai, 200080, China
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Shanghai, 200092, China
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Shenyang, 110004, China
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Taiyuan, 030001, China
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Wenzhou, 325000, China
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Xi'an, 710061, China
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Xuzhou, 221000, China
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Zhenjiang, 212021, China
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Cartagena, 130013, Colombia
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Konstanz, 78464, Germany
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Magdeburg, Germany
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Mainz, 55131, Germany
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Münster, 48149, Germany
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Hong Kong, 999077, Hong Kong
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Shatin, Hong Kong
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Hyderabad, 500072, India
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Jaipur, 302001, India
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Jaipur, 302018, India
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Punjab, 160062, India
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Surat, 395009, India
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Milan, 20122, Italy
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Palermo, 90127, Italy
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Roma, 00128, Italy
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Rome, 00168, Italy
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Torino, 10126, Italy
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Bunkyō City, 113-8655, Japan
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Fukui-shi, 918-8503, Japan
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Fukuoka, 810-0065, Japan
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Gifu, 500-8513, Japan
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Kagoshima, 890-8520, Japan
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Kawasaki-shi, 215-0026, Japan
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Kobe, 650-0017, Japan
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Kumamoto, 860-8556, Japan
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Kure-shi, 737-0023, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 602-8566, Japan
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Minatoku, 105-8470, Japan
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Nagoya, 460-0001, Japan
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Okayama, 700-8505, Japan
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Omura-shi, 856-8562, Japan
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Osaka, 545-8586, Japan
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Ōita, 870-0837, Japan
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Saga, 849-8501, Japan
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Shinjuku-ku, 160-0023, Japan
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Shinjuku-ku, 160-8582, Japan
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Shinjuku-ku, 162-8655, Japan
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Takasaki-shi, 370-0829, Japan
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Tsu, 514-8507, Japan
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Yokohama, 236-0004, Japan
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Yokohama, 245-8575, Japan
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Kota Kinabalu, 88586, Malaysia
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Kuala Lumpur, 56000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Pulau Pinang, 10450, Malaysia
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Seremban, 70300, Malaysia
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Acapulco, 39670, Mexico
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Guadalajara, 44340, Mexico
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Mexico City, 03330, Mexico
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Mexico City, 06700, Mexico
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Torreón, 27000, Mexico
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Veracruz, 91851, Mexico
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Xalapa, 91020, Mexico
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Chorrillos, Lima 9, Peru
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Lima, 15023, Peru
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Lima, 15036, Peru
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Lima, 15046, Peru
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Cebu, 6000, Philippines
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Puerto Princesa City, 5300, Philippines
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Roxas City, 5800, Philippines
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San Fernando City, 2000, Philippines
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Singapore, 119074, Singapore
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Singapore, 169608, Singapore
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Singapore, 308433, Singapore
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Junggu, 41944, South Korea
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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A Coruña, 15006, Spain
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Almería, 04009, Spain
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Lleida, 25198, Spain
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Málaga, 29010, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Adana, 01060, Turkey (Türkiye)
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Antalya, 07059, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Eskişehir, 26480, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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Rize, 530020, Turkey (Türkiye)
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

NONALCOHOLIC STEATOHEPATITIS