New pill aims to tame stubborn inherited cholesterol

NCT ID NCT07000136

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing if a new oral drug called AZD0780 can safely lower 'bad' LDL cholesterol in adults with a genetic condition that causes very high cholesterol. About 455 participants will take either the new drug or a placebo pill for a year, in addition to their current cholesterol medications. The main goal is to see how much the drug reduces cholesterol levels after 12 weeks compared to the placebo.

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Contacts and locations

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Locations

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Garden Grove, California, 92844, United States
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San Diego, California, 92111, United States
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Hialeah, Florida, 33012, United States
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Orlando, Florida, 32807, United States
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Peachtree Corners, Georgia, 30092, United States
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Chicago, Illinois, 60607, United States
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Hammond, Louisiana, 70403, United States
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Las Vegas, Nevada, 89119, United States
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New York, New York, 10029, United States
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Morganton, North Carolina, 28655, United States
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Cincinnati, Ohio, 45227, United States
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Lima, Ohio, 45805, United States
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Chattanooga, Tennessee, 37404, United States
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Houston, Texas, 77043, United States
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Humble, Texas, 77338, United States
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Kingwood, Texas, 77345, United States
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McAllen, Texas, 78503, United States
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Mesquite, Texas, 75149, United States
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Redmond, Washington, 98052, United States
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CABA, C1006ACC, Argentina
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Ciudad Autonoma de Bs As, C1023AAB, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Ciudad de Buenos Aires, C1425AGC, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000PBJ, Argentina
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Melbourne, 3004, Australia
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Campinas, 13060-080, Brazil
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São Caetano do Sul, 09521-160, Brazil
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São Paulo, 04004-030, Brazil
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São Paulo, 04012-180, Brazil
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São Paulo, 05403-000, Brazil
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Plovdiv, 4002, Bulgaria
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Sofia, 1527, Bulgaria
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Sofia, 1618, Bulgaria
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Vancouver, British Columbia, V6Z2H2, Canada
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London, Ontario, N6A 5A5, Canada
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Chicoutimi, Quebec, G7H 7K9, Canada
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Montreal, Quebec, H2W 1R7, Canada
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Québec, Quebec, G1V 4W2, Canada
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Trois-Rivières, Quebec, G9A 4P3, Canada
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Santiago, 7770086, Chile
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Valdivia, 5090000, Chile
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Hradec Králové, 500 05, Czechia
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Prague, 140 00, Czechia
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Prague, 19800, Czechia
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Uherské Hradiště, 686 01, Czechia
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Aarhus N, 8200, Denmark
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Copenhagen, 2400, Denmark
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Esbjerg, 6700, Denmark
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Herlev, 2730, Denmark
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Herning, 7400, Denmark
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Hvidovre, DK-2650, Denmark
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Viborg, 8800, Denmark
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Helsinki, 00290, Finland
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Kuopio, 70210, Finland
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Tampere, 33520, Finland
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Turku, 20520, Finland
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Bron, 69677, France
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Dijon, 21079, France
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Marseille, 13005, France
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Paris, 75013, France
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Saint-Herblain, 44093, France
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Berlin, 10559, Germany
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Dresden, 1307, Germany
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Leipzig, 04103, Germany
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Budapest, 1036, Hungary
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Budapest, 1132, Hungary
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Debrecen, 4032, Hungary
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Nyíregyháza, 4400, Hungary
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Székesfehérvár, 8000, Hungary
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Chūōku, 103-0027, Japan
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Fukushima, 960-1295, Japan
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Hamamatsu, 432-8580, Japan
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Ichikawa-shi, 272-8516, Japan
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Kanazawa, 920-8530, Japan
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Kanazawa, 920-8641, Japan
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Kishiwada-shi, 596-8522, Japan
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Kita-gun, 761-0793, Japan
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Komatsu-shi, 923-8560, Japan
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Minatoku, 108-0014, Japan
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Minatoku, 108-0073, Japan
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Okayama, 700-0804, Japan
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Okayama, 702-8055, Japan
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Osaka, 543-8922, Japan
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Suita-shi, 564-8565, Japan
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Takatsuki-shi, 569-8686, Japan
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Tamanashi, 865-0016, Japan
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Urasoe-Shi, 901-2102, Japan
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Yokohama, 247-8581, Japan
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Amsterdam, 1105 AZ, Netherlands
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Roosendaal, 4708 AE, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Christchurch, 8011, New Zealand
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Grafton, 1010, New Zealand
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Bodø, 8005, Norway
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Grålum, 1712, Norway
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Oslo, 0369, Norway
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Oslo, 0586, Norway
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Trondheim, 7030, Norway
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Bratislava, 83101, Slovakia
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Bratislava, 83106, Slovakia
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Košice, 04022, Slovakia
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Nitra, 949 11, Slovakia
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Žilina, 010 01, Slovakia
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 120-752, South Korea
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Seoul, 5278, South Korea
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A Coruña, 15006, Spain
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Barcelona, 08036, Spain
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Córdoba, 14004, Spain
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Reus, 43204, Spain
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Seville, 41013, Spain
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Gothenburg, 413 46, Sweden
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Linköping, 581 85, Sweden
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Lund, 22242, Sweden
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Stockholm, 117 27, Sweden
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Stockholm, 141 86, Sweden
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Uppsala, 75185, Sweden
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Västerås, 721 89, Sweden
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Kaohsiung City, 80756, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Adana, 01060, Turkey (Türkiye)
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Afyonkarahisar, 03030, Turkey (Türkiye)
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Ankara, 06530, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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İzmit, 41380, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Hồ Chí Minh, 9000, Vietnam

Conditions

Explore the condition pages connected to this study.

HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLAEMIA