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New hope for kids with stubborn transplant complication

NCT ID NCT07124078

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Dec 29, 2025 · Last updated May 16, 2026 · Updated 19 times

Summary

This study tests a new drug called axatilimab against the best current treatments for children aged 2 to 17 with chronic graft-versus-host disease (cGVHD), a serious complication after a stem cell transplant. Participants must have already tried at least two prior treatments. The goal is to see if axatilimab can better control the disease without needing new therapies.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust

    RECRUITING

    Cambridge, CB2 0QQ, United Kingdom

  • Adventhealth Pediatric Cellular Therapy and Blood and Marrow Transplant

    NOT_YET_RECRUITING

    Orlando, Florida, 32804, United States

  • Azienda Ospedaliera Universitaria Di Padova

    RECRUITING

    Padua, 35128, Italy

  • Birmingham Children'S Hospital - Birmingham Women'S and Children'S Nhs Foundation Trust

    RECRUITING

    Birmingham, B4 6NH, United Kingdom

  • Charite Campus Virchow

    NOT_YET_RECRUITING

    Berlin, 13353, Germany

  • Children'S Hospital Los Angeles Specialt

    NOT_YET_RECRUITING

    Los Angeles, California, 90027, United States

  • Childrens Healthcare of Atlanta

    NOT_YET_RECRUITING

    Atlanta, Georgia, 30329, United States

  • Childrens Hospital of Pittsburgh

    NOT_YET_RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Childrens National Medical Center

    NOT_YET_RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

  • Duke Cancer Center

    NOT_YET_RECRUITING

    Durham, North Carolina, 27710, United States

  • Fondazione Irccs Policlinico San Matteo Di Pavia Oncoematologia Pediatrica, Universita Di Pavia

    NOT_YET_RECRUITING

    Pavia, 27100, Italy

  • Fondazione Irccs San Gerardo Dei Tintori

    NOT_YET_RECRUITING

    Monza, 20900, Italy

  • Fred Hutchinson Cancer Research Center

    NOT_YET_RECRUITING

    Seattle, Washington, 98109, United States

  • Great Ormond Street Hospital Nhs Trust

    RECRUITING

    London, WC1N 3JH, United Kingdom

  • Hospital Infantil Unversitario Nino Jesus

    NOT_YET_RECRUITING

    Madrid, 28009, Spain

  • Hospital Regional Universitario de Malaga- Hospital Materno Infantil

    RECRUITING

    Málaga, 29011, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario Vall D'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen de La Arrixaca

    RECRUITING

    Murcia, 30120, Spain

  • Hôpital Universitaire Des Enfants Reine Fabiola

    RECRUITING

    Brussels, Belgium

  • Irccs - Aou Di Bologna - Sant'Orsola Malpighi

    NOT_YET_RECRUITING

    Bologna, 40138, Italy

  • Irccs Istituto G. Gaslini, Universita Di Genova

    NOT_YET_RECRUITING

    Genova, 16147, Italy

  • Irccs Ospedale Pediatrico Bambino Gesu

    RECRUITING

    Rome, 00165, Italy

  • Klinikum Der Johann Wolfgang Goethe-Universitaet

    RECRUITING

    Frankfurt am Main, 60590, Germany

  • Leeds Childrens Hospital

    RECRUITING

    Leeds, LS1 3EX, United Kingdom

  • Levine Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28203, United States

  • Lucile Packard Child Hospital End

    NOT_YET_RECRUITING

    Palo Alto, California, 94304, United States

  • Medizinische Hochschule Hannover (Mhh) - Zentrum Fuer Kinderheilkunde Und Jugendmedizin - Klinik Fue

    NOT_YET_RECRUITING

    Hanover, 30625, Germany

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Royal Manchester Children'S Hospital - Manchester University Nhs Foundation Trust

    RECRUITING

    Manchester, M139WL, United Kingdom

  • Royal Victoria Infirmary - the Newcastle Upon Tyne Hospitals Nhs Foundation Trust

    RECRUITING

    Newcastle, NE1 4LP, United Kingdom

  • Sheffield Children'S Hospital - Sheffield Children'S Nhs Foundation Trust

    RECRUITING

    Sheffield, S10 2TH, United Kingdom

  • St Mary'S Hospital, Paddington - Imperial College Healthcare Nhs Trust

    RECRUITING

    London, W2 1NY, United Kingdom

  • The Royal Hospital For Children - Glasgow Health Board

    RECRUITING

    Glasgow, G51 4TF, United Kingdom

  • Universitaetsklinikum Freiburg Zentrum Fuer Kinderheilkunde- Und Jugendmedizin Klinik Iv: Paediatris

    NOT_YET_RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    NOT_YET_RECRUITING

    Hamburg, 20246, Germany

  • Universitat de Valencia - Hospital Universitari I Politecnic La Fe de Valencia (Hospital La Fe Bulev

    RECRUITING

    Valencia, 46026, Spain

  • Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc

    RECRUITING

    Woluwe-Saint-Lambert, 01200, Belgium

  • University Hospital Regensburg

    NOT_YET_RECRUITING

    Regensburg, 93053, Germany

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE