New hope for transplant patients battling debilitating chronic GVHD

NCT ID NCT04710576

Ongoing Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing a drug called axatilimab for people with chronic graft-versus-host disease (cGVHD) that has come back or hasn't improved after trying at least two other treatments. The goal is to see if the drug can reduce the disease's severity and symptoms, and to find the best dose. About 241 participants will receive one of three different doses for up to two years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita

Torino, Italy
ASST degli Spedali Civili di Brescia

Brescia, Italy
ASST di Monza-Ospedale San Gerardo

Monza, Italy
AZ Delta

Roeselare, Belgium
AdventHealth Orlando

Orlando, Florida, 32806, United States
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Bristol Royal Hospital for Children

Bristol, BS2 8BJ, United Kingdom
CHRU de Lille - Hopital Claude Huriez

Lille, Hauts-de-France, 59037, France
CHRU de Nancy - Hôpitaux de Brabois

Nancy, France
CHU Amiens Picardie - Hopital Sud

Amiens, Hauts-de-France, 80054, France
CHU Bordeaux - Hopital Haut-Leveque - Centre François Magendie

Pessac, France
CHU Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
CHU de Grenoble

La Tronche, Auvergne-Rhône-Alpes, 38700, France
CHU de Nantes - Hôtel-Dieu

Nantes, France
Chaim Sheba Medical Center

Ramat Gan, 5262160, Israel
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
China Medical University Hospital

Taichung, 40447, Taiwan
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Citta della Salute e della Scienza di Torino - Ospedale le Molinette

Torino, Italy
City of Hope

Duarte, California, 91010, United States
Complejo Hospitalario Universitario de Granada - Hospital Universitario Virgen de las Nieves

Granada, 18014, Spain
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Emory University

Atlanta, Georgia, 30322, United States
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Fondazione IRCCS Policlinico San Matteo

Pavia, Italy
Fondazione Monza e Brianza per il Bambino e la sua Mamma

Monza, Italy
Fondazione Policlinica Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore

Roma, 168, Italy
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
General Hospital of Thessaloniki G. Papanikolaou - Hematology Department, BMT Unit

Eksochi, Thessaloniki, 57010, Greece
HCL Centre Hospitalier Lyon Sud

Pierre-Bénite, France
Hadassah Medical Center Ein Karem

Jerusalem, 9112001, Israel
Hammersmith Hospital

London, United Kingdom
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hopital Pitie Salpetriere

Paris, 75013, France
Hopital Saint Louis

Paris, 75010, France
Hospital Clinic Barcelona

Barcelona, 8032, Spain
Hospital Clinico Universitario de Salamanca

Salamanca, 37007, Spain
Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario Donostia

Donostia / San Sebastian, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marquis de Valdecilla

Santander, Spain
Hospital Universitario Puerta de Hierro

Majadahonda, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio

Seville, Seville, 41013, Spain
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
IUCT-Oncopole

Toulouse, Haure-Garrone, 31100, France
Indiana University Health Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Institut de cancérologie Strasbourg Europe (ICANS)

Strasbourg, Grand Est, 67200, France
Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E. (IPO-Lisboa)

Lisbon, 1099-023, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE

Porto, Portugal
Intermountain Healthcare

Salt Lake City, Utah, 84111, United States
Johns Hopkins Kimmel Cancer Center

Baltimore, Maryland, 21231-2410, United States
KK Women's and Children hospital

Singapore, 229899, Singapore
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 80756, Taiwan
King's College Hospital NHS Foundation Trust

London, United Kingdom
Korea University Anam Hospital

Seoul, South Korea
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
McGill University Health Center - Research Institute

Montreal, Quebec, H3G 1A4, Canada
Moffitt

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Oddzial w Gliwicach - Klinika Transplantacji Szpiku i Onkohematologii

Gliwice, 44-102, Poland
National Taiwan University Hospital

Taipei, 100, Taiwan
National University Hospital

Singapore, 119074, Singapore
Northside Hospital

Atlanta, Georgia, 30342, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Princess Margaret Hospital

Toronto, Ontario, Canada
Pusan National University Hospital

Busan, South Korea
Queen Elizabeth University Hospital

Glasgow, United Kingdom
Rambam Health Care Campus

Haifa, 3109601, Israel
Royal Marsden Foundation Trust

London, United Kingdom
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
Seoul National University Hospital

Seoul, South Korea
Severance Hospital

Seoul, South Korea
Singapore General Hospital

Singapore, Singapore
Stanford Cancer Center

Stanford, California, 94305, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel
The Cleveland Clinic Foundation

Lyndhurst, Ohio, 44195, United States
The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
The Royal Children's Hospital

Parkville, Victoria, 3052, Australia
The University of Chicago Medical Center (UCMC)

Chicago, Illinois, 60637, United States
Tulane University Medical Center

New Orleans, Louisiana, 70112, United States
Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, 01307, Germany
Universitaetsklinikum Jena

Jena, 07740, Germany
Universitaetsklinikum Leipzig

Leipzig, 04103, Germany
Universitaetsklinikum Muenster

Münster, 48149, Germany
Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz

Mainz, 55131, Germany
Universitaire Ziekenhuizen Leuven

Leuven, Belgium
Universitatsklinikum Regensburg

Regensburg, 93053, Germany
University General Hospital of Patras

Pátrai, 26500, Greece
University Hospital of Wales

Cardiff, United Kingdom
University Hospital of West Attica - Attikon - Hematology Division

Athens, Greece
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Alabama at Birmingham - Children's of Alabama

Birmingham, Alabama, 35233, United States
University of California, Los Angeles (UCLA) - Medical Center

Los Angeles, California, 90059, United States
University of Florida (UF)

Gainesville, Florida, 32610, United States
University of Massachusetts Memorial Medical Center

Worcester, Massachusetts, 01655, United States
University of Miami

Miami, Florida, 33136, United States
University of Michigan

Ann Arbor, Michigan, 48084, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Oklahoma - Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Medical Center - Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Southern California Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of Utah

Salt Lake City, Utah, 84112, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22908, United States
University of Wisconsin - Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Vancouver Coastal Health Authority

Vancouver, British Columbia, V5Z 1M9, Canada
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Weill Medical College of Cornell University

New York, New York, 10022, United States
Westmead Hospital

Westmead, Australia

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE