New drug trial targets uncontrollable anger after head trauma

NCT ID NCT03095066

Completed Symptom relief Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether an investigational drug called AVP-786 could help reduce severe behavioral problems like aggression, agitation, and irritability in people who have had a traumatic brain injury (TBI). 168 participants were randomly assigned to receive either the drug or a placebo for up to 12 weeks. The goal was to see if the medication could safely ease these difficult symptoms that persist after the initial injury.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ATP Clinical Research Site#150

Costa Mesa, California, 92626, United States
Absolute Clinical Research Site#207

Phoenix, Arizona, 85051, United States
Allied Biomedical Research Institute, Inc. Site#151

Miami, Florida, 33155, United States
Alphab Global Research Site#163

Jupiter, Florida, 33458, United States
Asclepes Research Centers - Panorama City Site #208

Panorama City, California, 91402, United States
Atrium Health - Carolinas Rehabilitation - Charlotte Site #166

Charlotte, North Carolina, 28203, United States
Baptist Health

Richmond, Kentucky, 40475, United States
Bradenton Research Center, Inc

Bradenton, Florida, 34205, United States
Carolina Headache Institute

Durham, North Carolina, 27713, United States
Cedar Clinical Research #221

Draper, Utah, 84020, United States
Cincinnati VA Medical Center

Cincinnati, Ohio, 45220, United States
Clinical Research Professionals

St Louis, Missouri, 63141, United States
Connecticut Clinical Research

Cromwell, Connecticut, 06416, United States
Design Neuroscience Center, PL

Doral, Florida, 33172, United States
Hawaii Pacific Neuroscience Site#184

Honolulu, Hawaii, 96817, United States
Health Synergy Clinical Research

Okeechobee, Florida, 34972, United States
Healthcare Innovative Institute, LLC Site# 173

Coral Springs, Florida, 33067, United States
IPS Research Site#196

Oklahoma City, Oklahoma, 73106, United States
JFK Johnson Rehabilitation Institute

Edison, New Jersey, 08820, United States
Kaizen Brain Center #224

La Jolla, California, 92037, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Meridien Research

Maitland, Florida, 32751, United States
Meridien Research Site# 108

Tampa, Florida, 33634, United States
Millennium Psychiatric Associates, LLC

Creve Coeur, Missouri, 63141, United States
Mountain Mind

Colorado Springs, Colorado, 80903, United States
Mountain View Clinical Research, Inc. Site# 202

Denver, Colorado, 80209, United States
Neurobehavioral Medicine Group #222

Bloomfield Hills, Michigan, 48302, United States
New Hope Clinical Research Site#194

Charlotte, North Carolina, 28211, United States
New York University School of Medicine Site #122

New York, New York, 10016, United States
North Star Medical Research, LLC Site#154

Middleburg Heights, Ohio, 44130, United States
Perseverance Research Center Site#152

Scottsdale, Arizona, 85254, United States
Polytrauma Rehabilitation Center S. Texas VA Health Care System Site# 146

San Antonio, Texas, 78229, United States
Premier Clinical Research Institute, Inc.

Miami, Florida, 33122, United States
Project 4 Research

Miami, Florida, 33125, United States
Roskamp Institute Clinic, Inc.

Sarasota, Florida, 34243, United States
Salem Research Institute Site# 138

Salem, Virginia, 24153, United States
Salisbury VAMC

Salisbury, North Carolina, 28144, United States
Science Connections, LLC Site#161

Doral, Florida, 33166, United States
Sharlin Health and Neurology

Ozark, Missouri, 65721, United States
Sisu BHR Site#200

Springfield, Massachusetts, 01103, United States
Sunwise Clinical Research, LLC Site#216

Lafayette, California, 94543, United States
The NeuroCognitive Insititute

Mount Arlington, New Jersey, 07856, United States
The Neurology Group

Pomona, California, 91767, United States
The University of Kentucky research foundation

Lexington, Kentucky, 40536, United States
Tibor Rubin VA Medical Center, SCIRE Biomedical Research Institute

Long Beach, California, 90822, United States
Torrance Clinical Research Institute Site#157

Lomita, California, 90717, United States
Tuscaloosa Veterans Affairs Medical Center

Tuscaloosa, Alabama, 35404, United States
USF Dept of Psychiatry and Behavioral Neurosciences Site# 214

Tampa, Florida, 33613, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Southwestern Medical Site#140

Dallas, Texas, 75390, United States
Valley Medical Research

Centerville, Ohio, 45459, United States
Virginia Commonwealth University #172

Richmond, Virginia, 23298, United States
Virginia Commonwealth University Site#172

Richmond, Virginia, 23298, United States
WJB Dorn VA-Wm. Jennings Bryan Dorn VA Medical Center

Columbia, South Carolina, 29205, United States

Conditions

Explore the condition pages connected to this study.

NEUROBEHAVIORAL DISINHIBITION