Could a super steroid tame blood cancers? new trial underway

NCT ID NCT04329728

Recruiting now Disease control Sponsor: AVM Biotechnology Inc Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a drug called AVM0703, a very strong steroid, given as a one-time IV infusion. It aims to see if it is safe and can shrink tumors in people with certain blood cancers like lymphoma and leukemia. The trial will enroll 144 participants aged 12 and older.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AVM0703 (a high-dose steroid given by IV infusion)
What this could lead to: If it works, this could offer a new treatment option for certain blood cancers that are hard to treat.
What could go wrong: This is an early-phase trial with only 144 participants, so results may not apply broadly. The drug is a high-dose steroid, which can cause serious side effects like infections or metabolic issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia B-cell chronic lymphocytic leukemia B-cell neoplasm diffuse large B-cell lymphoma follicular lymphoma leukemia Leukemia, B-Cell lymphoma lymphoproliferative syndrome mantle cell lymphoma T-cell leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOID MALIGNANCIES

Contacts and locations

Locations

ASCLEPES Research Centers
RECRUITING

Weeki Wachee, Florida, 34613, United States
Baptist Clinical Research Institute
RECRUITING

Memphis, Tennessee, 38120, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Gabrail Cancer Center Research,
RECRUITING

Canton, Ohio, 44718, United States
Innovative Clinical Research Institute
RECRUITING

Whittier, California, 92705, United States
Los Angeles Cancer Network
RECRUITING

Los Angeles, California, 90017, United States
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68124, United States
UCLA Medical Center of Hematology/Oncology
RECRUITING

Los Angeles, California, 90095, United States
University of Illinois at Chicago Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States
University of Texas(UT) Southwestern-Children's Medical Center
RECRUITING

Dallas, Texas, 75235, United States

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