New eczema drug shows promise in Mid-Stage trial

NCT ID NCT07011706

Ongoing Disease control Sponsor: Aclaris Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether ATI-045 can safely reduce eczema symptoms like redness, itching, and skin patches in people with moderate-to-severe disease. About 110 adults who haven't had success with topical treatments will receive either the drug or a placebo. The main goal is to see how much their eczema improves after 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ATI-045

What this could lead to

If successful, this could point toward a new treatment option for people with moderate-to-severe eczema that doesn't respond well to topical creams.

What could go wrong

This is an early Phase 2 trial with only 110 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease atopic eczema atopic IgE-mediated allergic disorder dermatitis Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AD ATOPIC ATOPIC DERMATITIS DERMATITIS ECZEMA

Contacts and locations

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Locations

Aclaris Clinical Site

Phoenix, Arizona, 85008, United States
Aclaris Clinical Site

Tucson, Arizona, 85704, United States
Aclaris Clinical Site

Beverly Hills, California, 90212, United States
Aclaris Clinical Site

Encino, California, 91436, United States
Aclaris Clinical Site

Huntington Beach, California, 92647, United States
Aclaris Clinical Site

Sherman Oaks, California, 91403, United States
Aclaris Clinical Site

Thousand Oaks, California, 91320, United States
Aclaris Clinical Site

Hollywood, Florida, 33486, United States
Aclaris Clinical Site

Jacksonville, Florida, 32256, United States
Aclaris Clinical Site

Margate, Florida, 33063, United States
Aclaris Clinical Site

Wellington, Florida, 33449, United States
Aclaris Clinical Site

Atlanta, Georgia, 30315, United States
Aclaris Clinical Site

Savannah, Georgia, 31405, United States
Aclaris Clinical Site

Lafayette, Indiana, 47906, United States
Aclaris Clinical Site

Ann Arbor, Michigan, 48103, United States
Aclaris Clinical Site

Troy, Michigan, 48084, United States
Aclaris Clinical Site

Ridgeland, Mississippi, 39157, United States
Aclaris Clinical Site

Missoula, Montana, 59804, United States
Aclaris Clinical Site

New York, New York, 10128, United States
Aclaris Clinical Site

The Bronx, New York, 10455, United States
Aclaris Clinical Site

Cary, North Carolina, 27518, United States
Aclaris Clinical Site

Wilmington, North Carolina, 28405, United States
Aclaris Clinical Site

Philadelphia, Pennsylvania, 19103, United States
Aclaris Clinical Site

Myrtle Beach, South Carolina, 29588, United States
Aclaris Clinical Site

Dallas, Texas, 75230, United States
Aclaris Clinical Site

Houston, Texas, 77004, United States
Aclaris Clinical Site

The Woodlands, Texas, 77380, United States
Aclaris Clinical Site

Providence, Utah, 84332, United States
Aclaris Clinical Site

Seattle, Washington, 98004, United States
Aclaris Clinical Site

Spokane, Washington, 99202, United States
Aclaris Clinical Site

Barrie, Ontario, L4M 7G1, Canada
Aclaris Clinical Site

Toronto, Ontario, M2N 3A6, Canada
Aclaris Clinical Site

Montreal, Quebec, H1Y3L1, Canada
Aclaris Site

Markham, Ontario, L3P 1X3, Canada
Aclaris Site

Mississauga, Ontario, L4Y 4C5, Canada
Aclaris Site

Richmond Hill, Ontario, L4B 1A5, Canada
Aclaris Site

Toronto, Ontario, M4W 2N2, Canada
Aclaris Study Site

Bryant, Arkansas, 71913, United States
Aclaris Study Site

Encinitas, California, 92024, United States
Aclaris Study Site

Los Angeles, California, 90045, United States
Aclaris Study Site

Oceanside, California, 92056, United States
Aclaris Study Site

Santa Monica, California, 90404, United States
Aclaris Study Site

Coral Gables, Florida, 33134, United States
Aclaris Study Site

North Miami Beach, Florida, 33162, United States
Aclaris Study Site

Sweetwater, Florida, 33172, United States
Aclaris Study Site

Tampa, Florida, 33607, United States
Aclaris Study Site

Boise, Idaho, 83706, United States
Aclaris Study Site

Clarksville, Indiana, 47129, United States
Aclaris Study Site

Indianapolis, Indiana, 46250, United States
Aclaris Study Site

West Lafayette, Indiana, 47906, United States
Aclaris Study Site

Bowling Green, Kentucky, 42104, United States
Aclaris Study Site

Auburn Hills, Michigan, 48326, United States
Aclaris Study Site

Saint Joseph, Missouri, 64506, United States
Aclaris Study Site

New York, New York, 10023, United States
Aclaris Study Site

New York, New York, 10075, United States
Aclaris Study Site

Camp Hill, Pennsylvania, 17011, United States
Aclaris Study Site

San Antonio, Texas, 78213, United States
Aclaris Study Site

San Antonio, Texas, 78218, United States
Aclaris Study Site

Webster, Texas, 77598, United States
Aclaris Study Site

Norfolk, Virginia, 23502, United States