New hope for stomach cancer: experimental drug combo targets tough tumors
NCT ID NCT07327229
First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 6 times
Summary
This study tests a new drug called ATG-022 combined with the immunotherapy pembrolizumab (Keytruda), with or without chemotherapy, in people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2) and is HER2-negative. The trial aims to find the best dose and see if the combination shrinks tumors or slows cancer growth. About 132 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ATG-022 (an experimental antibody) plus pembrolizumab (Keytruda) with or without chemotherapy (capecitabine and oxaliplatin)
- What this could lead to
- If successful, this could provide a new treatment option for people with a specific type of advanced stomach cancer that has limited current therapies.
- What could go wrong
- This is an early-phase trial (phase 1/2) with a small number of participants, so the combination may not prove effective or safe enough for wider use. Side effects from the drugs and chemotherapy are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anhui Provincial Hospital
RECRUITINGHefei, Anhui, China
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Anyang Tumor Hospital
RECRUITINGAnyang, Henan, China
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Beijing Cancer hospital
RECRUITINGBeijing, Beijing Municipality, China
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Cancer Institute&Hospital Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGLangfang, Hebei, China
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Fujian Provincial Cnacer Hospital
RECRUITINGFuzhou, Fujian, China
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Gansu Provincial Cnacer Hospital
NOT_YET_RECRUITINGLanzhou, Gansu, China
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General Hospital of Ningxia Medical University
RECRUITINGYinchuan, Ningxia, China
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Henan Cnacer Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, China
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Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, China
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Jiangsu Province Hospital
RECRUITINGNanjing, Jiangsu, China
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Jinan Central Hospital
RECRUITINGJinan, Shandong, China
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Shandong Cancer Hospital &Institue
RECRUITINGJinan, Shandong, China
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Shanxi provincial cancer hospital
RECRUITINGTaiyuan, Shanxi, China
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The Affiliated Hospital of Qingdao University
RECRUITINGQingdao, Shandong, China
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The First Affiliated Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, China
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The First Affiliated Hospital of Henan Medical Hospital
RECRUITINGXinxiang, Henan, China
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The First Affiliated Hospital of Nanchang University
RECRUITINGNanchang, Jiangxi, China
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The First Affiliated Hospital of XI'AN Jiaotong University
RECRUITINGXi’an, Shanxi, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGWenzhou, Zhejiang, China
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The First Affiliated Hospital of Zhenghzou University
RECRUITINGZhengzhou, Henan, China
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The First Hospital of China Medical University
RECRUITINGShenyang, Liaoning, China
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The First Hospital of Shanxi Medical University
RECRUITINGTaiyuan, Shanxi, China
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The Fourth Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, China
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The Second Affiliated Hospital of Soochow University
RECRUITINGSuzhou, Jiangsu, China
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Tianjin Medical Universuty Cancer Institute & Hospital
RECRUITINGTianjin, Tianjin Municipality, China
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Tongji Medical College of HUST
RECRUITINGWuhan, Hubei, China
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Tongren Hospital Shanghai Jiaotong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, China
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, China
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Xuzhou Central Hospital
NOT_YET_RECRUITINGXuzhou, Jiangsu, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI-Guided home training boost recovery from gastric cancer surgery?
- Can a new drug combo shrink Hard-to-Treat tumors?
- Can an immunotherapy combo shrink stomach tumors before surgery?
- Can adding immunotherapy to chemotherapy improve gastric cancer outcomes?
- Can immunotherapy outperform chemo after stomach cancer surgery?
- Can a smart drug home in on Hard-to-Treat cancers?