New hope for stomach cancer: experimental drug combo targets tough tumors
NCT ID NCT07327229
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a new drug called ATG-022 combined with the immunotherapy pembrolizumab (Keytruda), with or without chemotherapy, in people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2) and is HER2-negative. The trial aims to find the best dose and see if the combination shrinks tumors or slows cancer growth. About 132 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ATG-022 (an experimental antibody) plus pembrolizumab (Keytruda) with or without chemotherapy (capecitabine and oxaliplatin)
What this could lead to
If successful, this could provide a new treatment option for people with a specific type of advanced stomach cancer that has limited current therapies.
What could go wrong
This is an early-phase trial (phase 1/2) with a small number of participants, so the combination may not prove effective or safe enough for wider use. Side effects from the drugs and chemotherapy are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Anhui Provincial Hospital
NOT_YET_RECRUITINGHefei, Anhui, China
Contact
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Anyang Tumor Hospital
NOT_YET_RECRUITINGAnyang, Henan, China
Contact
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Beijing Cancer hospital
RECRUITINGBeijing, Beijing Municipality, China
Contact
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Cancer Institute&Hospital Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGLangfang, Hebei, China
Contact
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Fujian Provincial Cnacer Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, China
Contact
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Gansu Provincial Cnacer Hospital
NOT_YET_RECRUITINGLanzhou, Gansu, China
Contact
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General Hospital of Ningxia Medical University
NOT_YET_RECRUITINGYinchuan, Ningxia, China
Contact
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Henan Cnacer Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, China
Contact
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Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, China
Contact
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Jiangsu Province Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact
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Jinan Central Hospital
RECRUITINGJinan, Shandong, China
Contact
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Shandong Cancer Hospital &Institue
NOT_YET_RECRUITINGJinan, Shandong, China
Contact
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Shanxi provincial cancer hospital
RECRUITINGTaiyuan, Shanxi, China
Contact
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The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITINGQingdao, Shandong, China
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The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, Anhui, China
Contact
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The First Affiliated Hospital of Henan Medical Hospital
NOT_YET_RECRUITINGXinxiang, Henan, China
Contact
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The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, Jiangxi, China
Contact
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The First Affiliated Hospital of XI'AN Jiaotong University
NOT_YET_RECRUITINGXi’an, Shanxi, China
Contact
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The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITINGXiamen, Fujian, China
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The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITINGWenzhou, Zhejiang, China
Contact
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The First Affiliated Hospital of Zhenghzou University
NOT_YET_RECRUITINGZhengzhou, Henan, China
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The First Hospital of China Medical University
NOT_YET_RECRUITINGShenyang, Liaoning, China
Contact
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The First Hospital of Shanxi Medical University
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
Contact
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The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
Contact
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The Second Affiliated Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, Jiangsu, China
Contact
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Tianjin Medical Universuty Cancer Institute & Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, China
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Tongji Medical College of HUST
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact
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Tongren Hospital Shanghai Jiaotong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, China
Contact
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, China
Contact
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Xuzhou Central Hospital
NOT_YET_RECRUITINGXuzhou, Jiangsu, China
Contact