Aspirin shows promise in blocking ovarian cancer for High-Risk women

NCT ID NCT03480776

Ongoing Prevention Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking aspirin can prevent ovarian cancer in women with BRCA1 or BRCA2 gene mutations, who are at high risk. About 117 participants will take either aspirin or a placebo daily for up to 2 years before their scheduled risk-reducing surgery. Researchers will then examine the removed tissue for pre-cancerous or early cancerous changes to see if aspirin reduces their occurrence.

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Conditions

The condition(s) this trial relates to.

hereditary breast ovarian cancer syndrome ovarian cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER PREVENTION

Contacts and locations

Locations

CHUM-Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
CIUSSS de l'Est-de-I'lle-de-Montreal

Montreal, Quebec, H1T 2M4, Canada
CIUSSS de l'Estrie - Centre hospitalier

Sherbrooke, Quebec, J1H 5N4, Canada
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Clinical Research Unit at Vancouver Coastal

Vancouver, British Columbia, V5Z 1M9, Canada
Dr. H. Bliss Murphy Cancer Centre

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Hotel-Dieu de Quebec

Québec, Quebec, G1R 2J6, Canada
King Edward Memorial Hospital

Subiaco, Western Australia, 6008, Australia
Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
North York General Hospital

Toronto, Ontario, M2K 1E1, Canada
Peter McCallum Cancer Institute

Melbourne, Victoria, 3002, Australia
Prince of Wales Hospital

Randwick, New South Wales, 2031, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
St John of God Subiaco

Subiaco, Western Australia, 6008, Australia
Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Women's College Hospital

Toronto, Ontario, M5S 1B2, Canada