Could arginine toothpaste be the answer to dry mouth?

NCT ID NCT06365047

Ongoing Symptom relief Sponsor: Tufts University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether an arginine-containing toothpaste can change the acidity of saliva in people with dry mouth caused by medications. Seventy adults will use either the arginine toothpaste or a regular fluoride toothpaste for 12 weeks. Researchers will measure saliva pH and mouth bacteria to see if the toothpaste helps balance the oral environment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 8% arginine toothpaste
What this could lead to: If it works, this could point toward a simple, daily way to ease dry mouth discomfort for people taking multiple medications.
What could go wrong: This is a small, early-phase trial focused on mouth chemistry, not symptoms directly. The toothpaste may not meaningfully improve dryness or quality of life.

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Conditions

The condition(s) this trial relates to.

Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

XEROSTOMIA

Contacts and locations

Locations

Tufts University School of Dental Medicine

Boston, Massachusetts, 02111, United States

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