New drug ARC101 enters first human tests for Hard-to-Treat cancers

NCT ID NCT06672185

Recruiting now Disease control Sponsor: Third Arc Bio Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tests a new drug called ARC101 in 70 people with advanced solid tumors that have a specific marker (Claudin 6). The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. Participants must have ovarian, testicular, or other Claudin 6-positive cancers that have not responded to standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ARC101
What this could lead to: If it works, this could point toward a new treatment option for advanced solid tumors that are Claudin 6 positive.
What could go wrong: This is a very early, first-in-human study with only 70 participants. The drug may not be effective or could cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

BC Cancer Research Centre
RECRUITING

Vancouver, British Columbia, V5Z 0B4, Canada
Cabrini Health Research
RECRUITING

Malvern, Victoria, 3144, Australia
Cancer Research SA
RECRUITING

Adelaide, South Australia, 5000, Australia
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 0B1, Canada
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START San Antonio, LLC.
RECRUITING

San Antonio, Texas, 78229, United States
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Sunshine Coast University Private Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
The Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C4, Canada

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